Abstract: An article of footwear incorporating an upper formed by a forefoot component, a knitted workpiece, and a heel component is described. Each of the forefoot component, the knitted workpiece, and the heel component are separate from each other and joined along connection areas. Reinforcement elements cover the connection areas. In one embodiment, the knitted workpiece includes a collar portion and a throat portion extending from a forward end of the collar portion. The knitted workpiece also includes a medial lobe extending from one side of the throat portion and a lateral lobe extending from an opposite side of the throat portion from the medial lobe. The collar portion, the throat portion, the medial lobe, and the lateral lobe form a single unified knitted workpiece.

Abstract: A system may include one or more of a called device, a calling device, configured to call the called device, and a network module. The network module is configured to process incoming call information of a call placed to the called device and configured to route the call to a destination based on preferences of the called device.

Abstract: A system for analyzing noise in one or more electrophysiology studies is provided. The system includes at least one processor and at least one memory device. The memory device stores an application that adapts the at least one processor to: identify, based at least in part on a machine learning model, one or more noise fingerprints within data derived at least in part from one or more study signals acquired from one or more patients during the one or more electrophysiology studies.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least section wise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A system, for use with a leaflet of a valve of a subject's heart, comprises a catheter, a cutting device, a helical needle, and a suture. The catheter is transluminally advanceable toward the heart. The cutting device is advanceable distally out of the catheter, and is adapted to cut through tissue of the leaflet to form cut tissue and cut edges at the cardiac valve. The helical needle defines a helical lumen, the helical needle configured to be advanced distally out of the catheter and to rotationally extend through, and secure together, two tissue segments of the leaflet. The suture extends through the helical lumen of the helical needle. The helical needle and the suture are configured to extend along the two tissue segments of the leaflet to suture the two tissue segments to each other. Other embodiments are also described.

Abstract: The present disclosure relates to compounds that bind to human GITR, pharmaceutical compositions comprising such compounds, and methods of using such compounds.

Abstract: A medical scan viewing system is configured to: generate inference data via at least one inference function, based the at least one medical scan and further based on receiver operating characteristic (ROC) parameters that include at least one ROC set point; present for display, via an interactive user interface, medical image data corresponding to the at least one medical scan, the inference data and a ROC adjustment tool; generate, in response to user interaction with the ROC adjustment tool, at least one adjusted ROC set point; generate updated inference data via the at least one inference function, based the at least one medical scan and further based on the at least one adjusted ROC set point; and present for display, via the interactive user interface, the medical image data corresponding to the at least one medical scan and the updated inference data.

Abstract: A golf club head and golf club having large head dimensions, and large face characteristics, as well as unique mass property attributes driven by relationships not often considered in conventional club head design, to achieve a resistance to squaring the club head during a golf swing that is comfortable to the novice golfer, while increasing stability during off-center impacts and obtaining preferred launch characteristics. This is achieved in part via establishing a club head configuration and associated weight distribution to yield a center of gravity location that results in a preferred magnitude of Delta1 and Delta2 values, CG angle, moments of inertia, and associated ratios, relationships, and club head mass property characteristics influenced by these variables to achieve improved performance.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: Disclosed are examples of systems, apparatus, methods and computer program products for sharing and publishing files. In one aspect, the database system can maintain a user database, a file database and a library. The database system can receive a first request initiated by a first user to share a first file with one or more second users and, responsive to the first request, enable a second set of one or more permissions for each of the second users. The database system also can receive a second request initiated by the first user to publish the first file to the library and, responsive to the second request, publish the first file to the library. The database system additionally can restrict access to the published file based on permissions associated with the library.

Abstract: Systems and methods for removing carbonaceous clinker material from a coke oven are described. A coke oven can be provided including an oven floor, coke, and clinker material deposited on the oven floor. After a temperature of the coke oven has reached a first temperature (e.g., after heating coal in the oven to produce coke), the method includes increasing the temperature of the coke oven to a second temperature that is higher than the first temperature for a predetermined amount of time. After the predetermined amount of time, the temperature is reduced to a third temperature that is lower than the first temperature.

Abstract: A golf club head includes a club body including a crown, a sole, a skirt disposed between and connecting the crown and the sole and a face portion connected to a front end of the club body. The face portion includes a geometric center defining the origin of a coordinate system when the golf club head is ideally positioned, the coordinate system including an x-axis being tangent to the face portion at the origin and parallel to a ground plane, a y-axis intersecting the origin being parallel to the ground plane and orthogonal to the x-axis, and a z-axis intersecting the origin being orthogonal to both the x-axis and the y-axis. The golf club head defines a center of gravity CG, the CG being a distance CGY from the origin as measured along the y-axis and a distance CGZ from the origin as measured along the z-axis.

Abstract: An article of footwear incorporating an upper formed by a forefoot component, a knitted workpiece, and a heel component is described. Each of the forefoot component, the knitted workpiece, and the heel component are separate from each other and joined along connection areas. Reinforcement elements cover the connection areas. In one embodiment, the knitted workpiece includes a collar portion and a throat portion extending from a forward end of the collar portion. The knitted workpiece also includes a medial lobe extending from one side of the throat portion and a lateral lobe extending from an opposite side of the throat portion from the medial lobe. The collar portion, the throat portion, the medial lobe, and the lateral lobe form a single unified knitted workpiece.

Abstract: Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibitor therapies using the same.

Abstract: A semiconductor device including a first dielectric layer and a second dielectric layer is formed by forming an inhibitor layer over a semiconductor material. The inhibitor layer includes at least silicon and nitrogen. The semiconductor material is heated in an oxygen-containing ambient which oxidizes the inhibitor layer and forms the first dielectric layer which includes the oxidized inhibitor layer, and oxidizes the semiconductor material to form the second dielectric layer. The second dielectric layer is thicker than, the first dielectric layer. The first dielectric layer and the second dielectric layer each include at least 90 weight percent silicon dioxide and less than 1 weight percent nitrogen. The first dielectric layer and the second dielectric layer may be used to form gate dielectric layers for a first MOS transistor and a second MOS transistor that operates at a higher voltage than the first MOS transistor.

Abstract: An article of footwear incorporating an upper formed by a forefoot component, a knitted workpiece, and a heel component is described. Each of the forefoot component, the knitted workpiece, and the heel component are separate from each other and joined along connection areas. Reinforcement elements cover the connection areas. In one embodiment, the knitted workpiece includes a collar portion and a throat portion extending from a forward end of the collar portion. The knitted workpiece also includes a medial lobe extending from one side of the throat portion and a lateral lobe extending from an opposite side of the throat portion from the medial lobe. The collar portion, the throat portion, the medial lobe, and the lateral lobe form a single unified knitted workpiece.

Abstract: An article of footwear incorporating an upper formed by a forefoot component, a knitted workpiece, and a heel component is described. Each of the forefoot component, the knitted workpiece, and the heel component are separate from each other and joined along connection areas. Reinforcement elements cover the connection areas. In one embodiment, the knitted workpiece includes a collar portion and a throat portion extending from a forward end of the collar portion. The knitted workpiece also includes a medial lobe extending from one side of the throat portion and a lateral lobe extending from an opposite side of the throat portion from the medial lobe. The collar portion, the throat portion, the medial lobe, and the lateral lobe form a single unified knitted workpiece.

Abstract: A system may include one or more of a called device, a calling device, configured to call the called device, and a network module. The network module is configured to process incoming call information of a call placed to the called device and configured to route the call to a destination based on preferences of the called device.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.