Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: A nestable wing sail having two or more sections. Where one section is configured to nest inside the first section, and can move out of the first section to extend the effective sail area of the wing sail.

Abstract: A nestable wing sail having two or more sections. Where one section is configured to nest inside the first section, and can move out of the first section to extend the effective sail area of the wing sail.

Abstract: Concentrating particles in a turbulent gas flow may include receiving, in a receptacle, a turbulent gas flow that includes particles. The concentration of particles in a gas flow exiting the receptacle at a first port is increased as compared with a concentration of the particles in the gas flow received by the receptacle. The increased concentration of particles is accomplished by removing a portion of the gas flow by using a second port, and fluidly communicating the gas flow through a tube in the receptacle. The tube has a smaller diameter at the end of the tube at which the gas flow exits the tube than diameter at the end of the tube at which the gas flow is received.

Abstract: Concentrating particles in a turbulent gas flow may include receiving, in a receptacle, a turbulent gas flow that includes particles. The concentration of particles in a gas flow exiting the receptacle at a first port is increased as compared with a concentration of the particles in the gas flow received by the receptacle. The increased concentration of particles is accomplished by removing a portion of the gas flow by using a second port, and fluidly communicating the gas flow through a tube in the receptacle. The tube has a smaller diameter at the end of the tube at which the gas flow exits the tube than diameter at the end of the tube at which the gas flow is received.

Abstract: A particle-harvesting material includes a flexible, reusable, and thermally conductive material including a rough surface having dimples of a size within a first range of sizes, a microstructure including interstices of a second range of sizes, the second range of sizes including sizes smaller than the first range of sizes, and an etched portion on the rough surface configured to attract particles upon contact between the particles and the etched portion.

Abstract: Concentrating particles in a turbulent gas flow may include receiving, in a receptacle, a turbulent gas flow that includes particles. The concentration of particles in a gas flow exiting the receptacle at a first port is increased as compared with a concentration of the particles in the gas flow received by the receptacle. The increased concentration of particles is accomplished by removing a portion of the gas flow by using a second port, and fluidly communicating the gas flow through a tube in the receptacle. The tube has a smaller diameter at the end of the tube at which the gas flow exits the tube than diameter at the end of the tube at which the gas flow is received.

Abstract: Energy released from energized particles is sensed. Whether the energized particles include a possible energetic material is determined based on the sensed energy. If a determination is made that the energized materials include a possible energetic material, a spectral signature of the sensed energy is determined. The spectral signature of the sensed energy is compared to one or more known spectral signatures associated with energetic materials. Whether the possible energetic material is an actual energetic material is determined based on the comparison.

Abstract: A position of an object moving through a region of interest is determined, and at least one source of an air stream is selectively activated based on the determined position. The air stream is capable of dislodging a particle from the object moving through the region of interest. The air stream is directed toward the region of interest. An air collector is selectively activated, based on the determined position, to draw air from the region of interest. The drawn air is deposited on a sample collector, and the sample collector is analyzed to determine whether the deposition of the air stream left particles of a material of interest on the sample collector.

Abstract: A particle-harvesting material includes a flexible, reusable, and thermally conductive material including a rough surface having dimples of a size within a first range of sizes, a microstructure including interstices of a second range of sizes, the second range of sizes including sizes smaller than the first range of sizes, and an etched portion on the rough surface configured to attract particles upon contact between the particles and the etched portion.

Abstract: Concentrating particles in a turbulent gas flow may include receiving, in a receptacle, a turbulent gas flow that includes particles. The concentration of particles in a gas flow exiting the receptacle at a first port is increased as compared with a concentration of the particles in the gas flow received by the receptacle. The increased concentration of particles is accomplished by removing a portion of the gas flow by using a second port, and fluidly communicating the gas flow through a tube in the receptacle. The tube has a smaller diameter at the end of the tube at which the gas flow exits the tube than diameter at the end of the tube at which the gas flow is received.