Patents by Inventor Mark G Obukowicz
Mark G Obukowicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9770432Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: GrantFiled: June 14, 2016Date of Patent: September 26, 2017Assignee: Guangzhou Institutes of Biomedicine And Health, Chinese Academy of SciencesInventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
-
Patent number: 9763914Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: GrantFiled: June 14, 2016Date of Patent: September 19, 2017Assignee: Guangzhou Institutes of Biomedicine And Health, Chinese Academy of SciencesInventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
-
Publication number: 20170020843Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: ApplicationFiled: June 14, 2016Publication date: January 26, 2017Inventors: Yanmei ZHANG, John Jeffrey TALLEY, Mark G. OBUKOWICZ, Zhengchao TU, Micky TORTORELLA, Yican WANG, Jianqi LIU, Yan CHEN, Xiaorong LIU, Xin LU
-
Publication number: 20160287556Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: ApplicationFiled: June 14, 2016Publication date: October 6, 2016Inventors: Yanmei ZHANG, John Jeffrey TALLEY, Mark G. OBUKOWICZ, Zhengchao TU, Micky TORTORELLA, Yican WANG, Jianqi LIU, Yan CHEN, Xiaorong LIU, Xin LU
-
Patent number: 9371305Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: GrantFiled: August 10, 2012Date of Patent: June 21, 2016Assignee: Guangzhou Institutes of Biomedicine And Health, Chinese Academy of SciencesInventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
-
Publication number: 20150133538Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: ApplicationFiled: August 10, 2012Publication date: May 14, 2015Applicant: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesInventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
-
Publication number: 20140142316Abstract: The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.Type: ApplicationFiled: April 16, 2013Publication date: May 22, 2014Applicant: Pfizer Inc.Inventors: Hengmiao CHENG, Xiao HU, Kevin D. JEROME, Mark G. OBUKOWICZ, Lisa Maria OLSON, Paul V. RUCKER, Ronald Keith WEBBER
-
Patent number: 8445520Abstract: The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.Type: GrantFiled: December 21, 2011Date of Patent: May 21, 2013Assignee: Pfizer Inc.Inventors: Hengmiao Cheng, Xiao Hu, Kevin D. Jerome, Mark G. Obukowicz, Lisa Maria Olson, Paul V. Rucker, Ronald Keith Webber
-
Patent number: 8158660Abstract: The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.Type: GrantFiled: May 8, 2009Date of Patent: April 17, 2012Assignee: Pfizer Inc.Inventors: Hengmiao Cheng, Xiao Hu, Kevin D. Jerome, Mark G. Obukowicz, Lisa Maria Olson, Paul V. Rucker, Ronald Keith Webber
-
Patent number: 7138411Abstract: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I? wherein X, A1, A2, A3, A4, R, R?, R1 and R2 are as described in the specification.Type: GrantFiled: November 22, 2002Date of Patent: November 21, 2006Assignee: G.D. Searle & Co.Inventors: Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier, Jr., Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte
-
Patent number: 7109211Abstract: A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I? wherein X, A1, A2, A3, A4, R, R?, R1 and R2 are as described in the specification.Type: GrantFiled: August 19, 2004Date of Patent: September 19, 2006Assignee: Pharmacia Corporation (of Pfizer, Inc.)Inventors: Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J. Rogier, Jr., Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte
-
Patent number: 6806288Abstract: A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.Type: GrantFiled: February 2, 2000Date of Patent: October 19, 2004Assignee: G.D. Searle & Co.Inventors: Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier, Jr., Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartman, Cindy L Ludwig, Suzanne Metz, Donald E Korte
-
Publication number: 20040197429Abstract: The present invention is directed toward a method for inhibiting COX-2 in an organism. In particular, the method is preferably directed toward selectively inhibiting COX-2 in an organism. The method comprises administering to the organism an organic extract isolated from a plant wherein such extract inhibits COX-2. A method to purify a composition that exhibits COX-2 inhibition and COX-2 selective inhibition from the organic extract is also provided. In addition, a method for treating and/or preventing COX-2 mediated inflammation or inflammation-associated disorders in an organism is provided.Type: ApplicationFiled: April 2, 2004Publication date: October 7, 2004Applicant: Pharmacia CorporationInventors: Mark G. Obukowicz, Susan L. Hummert
-
Publication number: 20040185122Abstract: The present invention is directed toward a method for inhibiting COX-2 in an organism. In particular, the method is preferably directed toward selectively inhibiting COX-2 in an organism. The method comprises the step of administering to the organism an organic extract isolated from an edible plant wherein such extract inhibits COX-2. A method to purify a composition that exhibits COX-2 inhibition and COX-2 selective inhibition from the organic extract is also provided. In addition, a method for treating and/or preventing COX-2 mediated inflammation or inflammation-associated disorders in an organism is provided.Type: ApplicationFiled: April 2, 2004Publication date: September 23, 2004Applicant: Pharmacia CorporationInventors: Mark G. Obukowicz, Susan L. Hummert
-
Publication number: 20040126438Abstract: The present invention is directed toward a method for inhibiting COX-2 in an organism. In particular, the method is preferably directed toward selectively inhibiting COX-2 in an organism. The method comprises administering to the organism an organic extract isolated from a plant wherein such extract inhibits COX-2. A method to purify a composition that exhibits COX-2 inhibition and COX-2 selective inhibition from the organic extract is also provided. In addition, a method for treating and/or preventing COX-2 mediated inflammation or inflammation-associated disorders in an organism is provided.Type: ApplicationFiled: October 8, 2003Publication date: July 1, 2004Inventors: Mark G. Obukowicz, Susan L Hummert
-
Publication number: 20040062823Abstract: The present invention is directed toward a method for inhibiting COX-2 in an organism. In particular, the method is preferably directed toward selectively inhibiting COX-2 in an organism. The method comprises administering to the organism an organic extract isolated from a non-edible plant wherein such extract inhibits COX-2 . A method to purify a composition that exhibits COX-2 inhibition and COX-2 selective inhibition from the organic extract is also provided. In addition, a method for treating and/or preventing COX-2 mediated inflammation or inflammation-associated disorders in an organism is provided.Type: ApplicationFiled: October 8, 2003Publication date: April 1, 2004Inventors: Mark G. Obukowicz, Susan L. Hummert
-
Publication number: 20040052870Abstract: The present invention is directed toward a method for inhibiting COX-2 in an organism. In particular, the method is preferably directed toward selectively inhibiting COX-2 in an organism. The method comprises the step of administering to the organism an organic extract isolated from an edible plant wherein such extract inhibits COX-2 A method to purify a composition that exhibits COX-2 inhibition and COX-2 selective inhibition from the organic extract is also provided. In addition, a method for treating and/or preventing COX-2 mediated inflammation or inflammation-associated disorders in an organism is provided.Type: ApplicationFiled: September 30, 2003Publication date: March 18, 2004Inventors: Mark G. Obukowicz, Susan L. Hummert
-
Publication number: 20040044028Abstract: Combinations of omega-3 polyunsaturated fatty acids (PUFAS) and cyclooxygenase-2 selective inhibitors for treatment or prevention of cardiovascular disease, inflammation related disorders or cancer are disclosed. The preferred omega-3 PUFAs of the present invention have from between eighteen and twenty-two carbon atoms, and more preferably from twenty to twenty-two carbon atoms.Type: ApplicationFiled: April 1, 2002Publication date: March 4, 2004Inventor: Mark G. Obukowicz
-
Publication number: 20040038977Abstract: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders.Type: ApplicationFiled: November 22, 2002Publication date: February 26, 2004Applicant: G.D. Searle & Co.Inventors: Jeffery S. Carter, Mark G. Obukowicz, Balekudru Devadas, John J. Talley, David L. Brown, Matthew J. Graneto, Stephen R. Bertenshaw, Donald J. Rogier, Srinivasan Raj Nagarajan, Cathleen E. Hanau, Susan J. Hartmann, Cindy L. Ludwig, Suzanne Metz, Donald E. Korte
-
Publication number: 20040003432Abstract: A method of producing a hexosamine comprises providing a cell having genes encoding each enzyme required for a biosynthetic pathway capable of synthesizing the hexosamine where at least one gene in the pathway is a heterologous gene. Compositions and methods of producing transgenic cells, expression vectors, transgenic plants, and nutritional material that contain hexosamines are also provided, as are methods for preventing, treating, and inhibiting arthritis and articular-joint damage or disease in subjects in need of such prevention, treatment and/or inhibition.Type: ApplicationFiled: May 5, 2003Publication date: January 1, 2004Applicant: Pharmacia CorporationInventor: Mark G. Obukowicz