Abstract: In embodiments a neural interface comprising at least one C-ring portion can be used to apply a pressure in a range of 0 mmHg to 30 mmHg to a target tissue arranged within the C-ring portion and comprising at least one electrode arranged on the at least one C-ring portion.

Abstract: A sheet driver for use in a medicament dispenser with blister pockets includes: (a) a base, extending from the base, (b) a shaft defining a rotational axis; at the base, (c) a drive surface for receipt of drive to rotate the base about the rotational axis; about the shaft, (d) a torsion spring defining first and second spring legs; mounting about the shaft and the torsion spring for rotation about the rotational axis, and (e) a hub defining a hub surface for receipt of a sheet of the medicament carrier, the hub surface being adapted to provide an initial effective winding surface which provides uniform indexing of the medicament carrier.

Abstract: There is provided an inhaler device comprising a housing, a mouthpiece, a seat for receiving a unit dose blister and a punch for piercing a lid of the unit dose blister. The housing comprises a base and a lid pivotally joined by a hinge, such that the lid is pivotable from a first ‘closed’ position in which it abuts the base to define a cavity, to a second ‘open’ position in which the cavity can be accessed. The seat and the punch are adapted to lie within the cavity when the lid is in the first ‘closed’ position and moving the lid from the ‘open’ position to the ‘closed’ position causes the punch to pierce a lid of a unit dose blister received in the seat. Only the lid of the unit dose blister is pierced.

Abstract: A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack comprises a body defining a chimney having a chimney inlet and a chimney exit, and defining a chamber having a chamber inlet and a chamber exit, wherein the chimney exit and said chamber inlet lie side-by-side such that when the open blister pocket is positioned adjacent thereto airflow is directed from the chimney exit to the chamber inlet via the open blister pocket, and wherein one or more bleed holes are provided between the chimney and the chamber such that bleed airflow is able to be directed into the chamber to disruptively impact the airflow that transports the entrained medicament powder.

Abstract: A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack comprises a body defining a chimney having a chimney inlet and a chimney exit, and defining a chamber having a chamber inlet and a chamber exit, wherein the chimney exit and said chamber inlet lie side-by-side such that when the open blister pocket is positioned adjacent thereto airflow is directed from the chimney exit to the chamber inlet via the open blister pocket, and wherein one or more bleed holes are provided between the chimney and the chamber such that bleed airflow is able to be directed into the chamber to disruptively impact the airflow that transports the entrained medicament powder.

Abstract: A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack comprises a body, the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from said chimney inlet to the chimney exit; the body further defining a chamber having a chamber inlet and a chamber exit, wherein the chimney exit and the chamber inlet lie side-by-side each other such that when the open blister pocket of the blister pack is positioned adjacent thereto the airflow is directed from the chimney exit to the chamber inlet via the open blister pocket to entrain the medicament powder and enable transport thereof in the airflow from the chamber inlet to the chamber exit, and wherein one or more bleed holes are provided between the chimney and the chamber such that bleed airflow is able to be directed into the chamber to disruptively impact the airflow that transports the entrained medicament powder.

Abstract: A sheet driver for use in a medicament dispenser including a medicament carrier having a plurality of pockets for containing medicament wherein the pockets are spaced along the length of and defined between first and second sheets secured to each other and separable by drivable pulling action, the sheet driver comprises a hub having a hub surface which is adapted to provide an initial effective winding surface which provides uniform indexing of the medicament carrier, and the tensioning of a torsion spring compensates for an increase in the effective winding surface of the hub caused by receipt of the sheet of the medicament carrier about the hub.

Abstract: There is provided a sheet driver for use in a medicament dispenser including a medicament carrier having a plurality of pockets for containing medicament wherein said pockets are spaced along the length of and defined between first and second sheets secured to each other and separable by drivable pulling action, the sheet driver comprising a base; ascending from the base, a shaft defining a rotational axis; on the base, a drive surface for receipt of drive to rotate the base about the rotational axis; about the shaft, a torsion spring defining first and second spring legs; mounting about the shaft and the torsion spring for rotation about the rotational axis, a hub defining a hub surface for receipt of a sheet of the medicament carrier. A first leg receiver of the base receives the first spring leg of the torsion spring and a second leg receiver of the hub receives the second spring leg of the torsion spring such that relative rotation of the base and the hub results in tensioning of the torsion spring.

Abstract: There is provided a manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack. The manifold comprises a body, the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from the chimney inlet to the chimney exit; the body further defining a chamber having a chamber inlet and a chamber exit. The chimney exit and said chamber inlet lie side-by-side each other such that when said open blister pocket of said blister pack is positioned adjacent thereto said airflow may be directed from the chimney exit to the chamber inlet via the open blister pocket to entrain said medicament powder and enable transport thereof in the airflow from the chamber inlet to said chamber outlet. The chamber is arranged to promote break up of said entrained medicament powder by exposing the entrained medicament powder to one or more regions of differential force during its transport through the chamber.

Abstract: A medicament dispenser device suitable for the delivery of medicament powder from an open blister pocket of at least one blister pack, the dispenser device comprises (a) a housing; (b) provided to the housing, an air inlet; (c) enclosed by the housing, a dispensing mechanism for the dispensing of medicament powder from an open blister pocket of at least one blister pack receivable thereby; and (d) associated with the dispensing mechanism and in communication with said air inlet, a manifold comprising (i) a body, (ii) the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from the chimney inlet to the chimney exit; (iii) the body further defining a chamber having a chamber inlet and a chamber exit, (iv) wherein the chimney exit and the chamber inlet lie side-by-side each other such that when the open blister pocket of the blister pack is positioned adjacent thereto the airflow will be directed from the chimney exit to the chamber inlet via the open blister pocket to entra

Abstract: A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack comprises a body, the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from said chimney inlet to the chimney exit; the body further defining a chamber having a chamber inlet and a chamber exit, wherein the chimney exit and the chamber inlet lie side-by-side each other such that when the open blister pocket of the blister pack is positioned adjacent thereto the airflow is directed from the chimney exit to the chamber inlet via the open blister pocket to entrain the medicament powder and enable transport thereof in the airflow from the chamber inlet to the chamber exit, and wherein one or more bleed holes are provided between the chimney and the chamber such that bleed airflow is able to be directed into the chamber to disruptively impact the airflow that transports the entrained medicament powder.

Abstract: There is provided a medicament dispenser comprising a medicament container having a dispensing mechanism; a container seat for receipt of the container; an anchor station; and drive means capable of moving the container seat relative to the anchor station to actuate the dispensing mechanism. The drive means is actuable in response to the application of non-mechanical energy thereto, and gear means are provided to the drive means to gear up the torque provided thereby.