Patents by Inventor Mark Hellberg

Mark Hellberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of MDCK cell line to predict corneal penetration of drugs
    Publication number: 20050239050
    Abstract: A new method of evaluating the ability of drug molecules to penetrate the cornea is described. The permeation rate of the drug molecules in MDCK cells is utilized to predict the ability of the molecules to penetrate the cornea. The method is useful for in vitro screening of potential new ophthalmic drugs, as well as in the design of new drug molecules for topical ocular administration.
    Type: Application
    Filed: April 25, 2005
    Publication date: October 27, 2005
    Inventors: Andrew Rusinko, Mark Hellberg, Jesse May, Geoffrey Owen
  • Statins for the treatment of ocular hypertension and glaucoma
    Publication number: 20050239871
    Abstract: The use of HMG-CoA reductase inhibitors (e.g., statins) to treat glaucoma, control intraocular pressure, preserve the trabecular meshwork, protect against ocular neurodegeneration and/or protect against glaucomatous retinopathy is described. The preferred HMG-CoA reductase inhibitors, which are statins having an RI value of 0.2 to 0.7 (e.g., pravastatin), are administered via topical application to the affected eye(s) of the patient.
    Type: Application
    Filed: April 25, 2005
    Publication date: October 27, 2005
    Inventors: Mark Hellberg, Debra Fleenor, Allan Shepard, Iok-Hou Pang
  • Novel benzopyran analogs and their use for the treatment of glaucoma
    Publication number: 20050209314
    Abstract: Novel benzopyran analogs are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.
    Type: Application
    Filed: May 6, 2005
    Publication date: September 22, 2005
    Inventors: Mark Hellberg, Abdelmoula Namil
  • Superoxide dismutase mimics for the treatment of ocular disorders and diseases
    Publication number: 20050032768
    Abstract: The use of SOD mimics particularly pentsaaacycle Mn(II) complex SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Application
    Filed: December 6, 2002
    Publication date: February 10, 2005
    Inventors: Peter Klimko, Robert Collier Jr., Mark Hellberg
  • Combinations of DP and FP type prostaglandins for lowering IOP
    Patent number: 6166073
    Abstract: Compositions containing DP-agonist and FP-agonists prostaglandin agonists and methods of their use in treating glaucoma or ocular hypertension are disclosed.
    Type: Grant
    Filed: August 2, 1999
    Date of Patent: December 26, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Thomas R. Dean, Mark Hellberg, Verney L. Sallee
  • Esters of non-steroidal anti-flammatory carboxylic acids
    Patent number: 5998465
    Abstract: Compounds having anti-inflammatory and anti-oxidant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresponding pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: December 7, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark Hellberg, Pete Delgado, Jon C. Nixon
  • Use of .omega.-conotoxin analogs for treating retinal and optic nerve head damage
    Patent number: 5965534
    Abstract: The invention is directed to the use of .omega.-conotoxins for the prevention and treatment of retinal or optic nerve head damage in humans. Compositions and methods are disclosed.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: October 12, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Iok-Hou Pang, Michael Kapin, Mark Hellberg
  • Anti-oxidant esters of non-steroidal anti-inflammatory agents
    Patent number: 5908849
    Abstract: Compounds having anti-inflammatory and anti-oxidant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresponding pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: June 1, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark Hellberg, Pete Delgado, Jon C. Nixon
  • Anti-oxidant esters of non-steroidal anti-inflammatory agents
    Patent number: 5750564
    Abstract: Compounds having anti-inflammatory and anti-oxidant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresponding pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: May 12, 1998
    Inventors: Mark Hellberg, Pete Delgado, Jon C. Nixon
  • 3-Oxa-D-prostaglandins for lowering IOP
    Patent number: 5700835
    Abstract: Compositions containing 3-Oxa-D-prostaglandins and methods of their use in treating glaucoma or ocular hypertension are disclosed.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: December 23, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Thomas R. Dean, Mark Hellberg, Verney L. Sallee