Patents by Inventor Mark Hyland
Mark Hyland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230228732Abstract: There is disclosed a nanopore support structure comprising a wall layer comprising walls defining a plurality of wells, and overhangs extending from the walls across each of the wells, the overhang defining an aperture configured to support a membrane suitable for insertion of a nanopore. There is further disclosed a nanopore sensing device comprising a nanopore support structure, and methods of manufacturing the nanopore support structure and the nanopore sensing device.Type: ApplicationFiled: April 29, 2021Publication date: July 20, 2023Applicant: Oxford Nanopore Technologies PLCInventors: Ping Xie, Justin Millis, Ken Healy, James Anthony Clarke, Jason Robert Hyde, Richard Kenneth John Wiltshire, Jonathan Edward McKendry, Robert Greasty, Clive Gavin Brown, loana Pera, Gurdial Singh Sanghera, Mark Hyland, Pedro Miguel Ortiz Bahamon, Mark David Jackson, Paul Raymond Mackett, Rhodri Rhys Davies
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Publication number: 20220396013Abstract: The invention relates to a method of forming a sensing device for supporting a plurality of nanopores upon an array of wells. The method involves providing a substrate, said substrate having a surface having an array of electrodes located thereon for connecting to or for configuring upon an electronic circuit. Separately, a well array structure is provided, which has an array of walls defining through-holes for defining wells. The substrate and well array structures are aligning said array of electrodes define, at least in part, a portion of the bases of respective wells at the bottom of the through holes. The resulting sensing device overcomes problems with known sensing devices by employing a substrate and/or well array structure, or hybrid thereof, that employs alternative materials or manufacturing processes.Type: ApplicationFiled: October 23, 2020Publication date: December 15, 2022Applicant: Oxford Nanopore Technologies PLCInventors: Pedro Miguel Ortiz Bahamon, Paul Raymond Mackett, Robert Greasty, Jonathan Edward McKendry, Jason Robert Hyde, Mark David Jackson, Richard Kenneth John Wiltshire, Rhodri Rhys Davies, Mark Hyland, James Anthony Clarke, Gurdial Singh Sanghera
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Patent number: 8518236Abstract: A method for improving the precision of electrochemical measurements made using an electrochemical cell is provided. The method comprises preconditioning a working electrode of the cell by (i) baking the working electrode; and/or (ii) incubating the working electrode; and/or (iii) applying a preconditioning potential across the cell; and/or (iv) treating the working electrode with a UV laser.Type: GrantFiled: June 28, 2006Date of Patent: August 27, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Patricia Mary Elizabeth Roblin, Mark Hyland, Christopher Paul Newman
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Patent number: 8282797Abstract: An electrochemical sensing method that includes (a) providing an electrochemical cell having a working electrode and a pseudo reference electrode; (b) providing a sample comprising a metal, the sample being in contact with the working electrode and the metal being capable of being oxidized or reduced at the working electrode when the metal is bound to the working electrode; (c) preconditioning the working electrode by (i) applying a time varying preconditioning potential between the working and pseudo reference electrodes; and/or (ii) baking the working electrode; and/or (iii) air-ageing the working electrode; and (d) applying a measuring potential between the working and pseudo reference electrodes and, during application of said measuring potential, measuring the current generated by oxidation/reduction of the metal at the working electrode.Type: GrantFiled: June 29, 2005Date of Patent: October 9, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Mark Hyland, Alan Maxwell Bond
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Patent number: 8239138Abstract: A scaling factor for scaling an output of a first electrochemical cell, is determined in order to compensate for the effect on the output caused by an variation in value of a property of a working electrode of the first cell from a reference value of that property. A measured value for the property is obtained from a portion of material formed so as to have substantially the same value of the property as does the working electrode and the measured value is processed to generate the scaling factor.Type: GrantFiled: September 7, 2006Date of Patent: August 7, 2012Assignee: Oxford Biosensors Ltd.Inventors: Mark Hyland, Lindy Murphy, Kevin Lorimer
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Patent number: 7972487Abstract: The invention concerns an electrochemical cell which, either alone or together which a substrate onto which it is placed, is in the form of a receptacle. The electrochemical cell contains a working electrode and a counter electrode, the working electrode being in a wall of the receptacle. At least one of the electrodes has at least one dimension of less than 50 ?m. The electrochemical cell is principally intended for use as a micro-electrode suitable for screening water, blood, urine or other biological or non-biological fluids.Type: GrantFiled: December 23, 2002Date of Patent: July 5, 2011Assignee: Roche Diagnostics Operations, Inc.Inventors: Mark Hyland, Kevin Lorimer, Ronald Neil Butler, Emma Naomi Kathlene Wallace-Davis, Yann Astier
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Publication number: 20100326844Abstract: A channel is provided for conveying fluid by capillary action between a first end of the channel and a second end of the channel, in which the channel is fully enclosed within an object and the cross-section of the channel has a concave shape, encouraging capillary flow.Type: ApplicationFiled: December 11, 2009Publication date: December 30, 2010Inventors: Mark Hyland, Sylvain Hallynck, Christian Schoen, Michael Wagener
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Publication number: 20100140108Abstract: A method for improving the precision of electrochemical measurements made using an electrochemical cell is provided. The method comprises preconditioning a working electrode of the cell by (i) baking the working electrode; and/or (ii) incubating the working electrode; and/or (iii) applying a preconditioning potential across the cell; and/or (iv) treating the working electrode with a UV laser.Type: ApplicationFiled: June 28, 2006Publication date: June 10, 2010Inventors: Patricia Mary Elizabeth Roblin, Mark Hyland, Christopher Paul Newman
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Publication number: 20090294304Abstract: A composition suitable for use in an electrochemical detection of ischeamia via albumin cobalt finding test (ACB), said composition comprising (i) a transition metal salt eg. Cobalt; (ii) an electrode area normalising agent having a current which is dependent on electrode area eg. RU (NH3)6; and (iii) a wetting agent eg. PVP. Also provided is a device comprising—an electrochemical cell having a working electrode (5) and a pseudo reference electrode (6); a composition according to the invention (7); —means for applying a voltage across the cell; and —means for measuring the resulting current across the cell. The device can be used in the electrochemical diagnosis of ischemia.Type: ApplicationFiled: June 29, 2005Publication date: December 3, 2009Inventors: Mark Hyland, Yann Astier
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Patent number: 7569081Abstract: A method is provided for automated converting of a web of a thin patterned catalyst-coated membrane to separate membrane sheets for fuel cell assembly. The membrane typically has a thickness of about one thousandth of an inch. Automated web converting involves transporting, with use of a movable vacuum, an end portion of the membrane web from a first location to a second location. With use of respective first and second vacuums at the first and second locations, and after removal of the movable vacuum, the end portion of the membrane web is releasably secured at the first and second locations. The membrane web is cut within a gap defined between a single catalyst pattern of the membrane web end portion and an adjacent catalyst pattern to produce a membrane sheet. The membrane sheet is precisely positioned to a desired orientation to facilitate subsequent processing of the membrane sheet.Type: GrantFiled: March 9, 2004Date of Patent: August 4, 2009Assignee: 3M Innovative Properties CompanyInventors: Gary William Schukar, John Russell Mlinar, Mark Hyland Smith, Steven Mark Spicer
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Publication number: 20090159464Abstract: An electrochemical sensing method comprising: (a) providing an electrochemical cell having a working electrode and a pseudo reference electrode; (b) providing a sample comprising a metal, the sample being in contact with the working electrode and the metal being capable of being oxidised or reduced at the working electrode when the metal is bound to the working electrode; (c) preconditioning the working electrode by (i) applying a time varying preconditioning potential between the working and pseudo reference electrodes; and/or (ii) baking the working electrode; and/or (iii) air-ageing the working electrode; and (d) applying a measuring potential between the working and pseudo reference electrodes and, during application of said measuring potential, measuring the current generated by oxidation/reduction of the metal at the working electrode.Type: ApplicationFiled: June 29, 2005Publication date: June 25, 2009Inventors: Mark Hyland, Alan Maxwell Bond
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Patent number: 7545148Abstract: In an electrochemical sensor, the potential difference applied to the electrochemical cell is raised to a measuring value at a rate determined to reduce the transient current. The maximum rate of change of the voltage is set to prevent saturation of an IE converter. The electrochemical cell may contain micro-electrodes as working and reference electrodes. The method may be applied to a battery powered, handheld device.Type: GrantFiled: August 3, 2005Date of Patent: June 9, 2009Assignee: Oxford Biosensors LimitedInventors: Kevin Lorimer, John Griffiths, Mark Hyland, Herbert Frank Askew, John Morton Broughall
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Publication number: 20090093979Abstract: A scaling factor for scaling an output of a first electrochemical cell, is determined in order to compensate for the effect on the output caused by an variation in value of a property of a working electrode of the first cell from a reference value of that property. A measured value for the property is obtained from a portion of material formed so as to have substantially the same value of the property as does the working electrode and the measured value is processed to generate the scaling factor.Type: ApplicationFiled: September 7, 2006Publication date: April 9, 2009Inventors: Mark Hyland, Lindy Murphy, Kevin Lorimer
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Patent number: 7467048Abstract: In an electrochemical sensor, a peak is detected by grouping data points in windows and detecting two or three windows between which the slope of the data changes sign. The peak can be more precisely detected by detecting the highest data point in the two or three windows.Type: GrantFiled: August 3, 2005Date of Patent: December 16, 2008Assignee: Oxford Biosensors LimitedInventors: Kevin Lorimer, John Griffiths, Mark Hyland
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Publication number: 20080305008Abstract: A micro-fluidic structure such as a bio-sensor device has a dispensing element for fluid and a destination zone in communication with, and downstream of, the dispensing element. A bridge structure extends to the dispensing element and promotes fluid passage across the bridge structure from the dispensing element toward the destination zone.Type: ApplicationFiled: December 20, 2006Publication date: December 11, 2008Applicant: OXFORD BIOSENSORS LIMITEDInventors: Mark Hyland, Peter Kevin Stephenson, Florent Francois Marie Crepineau
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Publication number: 20080190783Abstract: The invention concerns a device comprising an electrochemical cell. The device comprises a strip having a receptacle or partial receptacle formed therein. The working electrode of the electrochemical cell is in a wall of the receptacle or partial receptacle, and a pseudo reference electrode of the electrochemical cell is present as a layer on top of the surface of the strip. The device of the invention is useful in electrochemical sensing techniques.Type: ApplicationFiled: June 29, 2005Publication date: August 14, 2008Applicant: OXFORD BIOSENSORS LIMITEDInventor: Mark Hyland
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Publication number: 20080116082Abstract: A process for producing a device comprising an electrochemical cell, said device comprising a strip having a receptacle or partial receptacle formed therein, a working electrode of the electrochemical cell being located in a wall of the receptacle or partial receptacle, wherein the process comprises the steps of—forming a laminate comprising a working electrode layer between two insulating layers; —creating a hole or well in the laminate, the hole or well passing through the working electrode layer; and optionally—attaching the laminate to a base, to form a receptacle; wherein said step of creating a hole or well comprises laser drilling the laminate.Type: ApplicationFiled: June 14, 2005Publication date: May 22, 2008Inventors: Mark Hyland, Kevin Lorimer, Peter James Dobson, Herbert Frank Askew
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Publication number: 20070285099Abstract: In an electrochemical sensor, the potential difference applied to the electrochemical cell is raised to a measuring value at a rate determined to reduce the transient current.Type: ApplicationFiled: August 3, 2005Publication date: December 13, 2007Inventors: Kevin Lorimer, John Griffiths, Mark Hyland, Herbert Askew, John Broughall
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Publication number: 20070276611Abstract: In an electrochemical sensor, a peak is detected by grouping data points in windows and detecting two or three windows between which the slope of the data changes sign. the peak can be more precisely detected by detecting the highest data point in the two or three windows.Type: ApplicationFiled: August 3, 2005Publication date: November 29, 2007Inventors: Kevin Lorimer, John Griffiths, Mark Hyland
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Publication number: 20070259262Abstract: A method of confining an electroactive substance within an electrochemical cell in the form of a receptacle, said method that includes (a) providing an electrochemical cell in the form of a receptacle, the receptacle having a first open part to allow entry of a sample into the receptacle, and a second open part to allow escape of air displaced by the entering sample, the electrochemical cell having a working electrode and a counter electrode; (b) providing an electroactive substance, which substance is contained within the receptacle; (c) providing a permeable or semi-permeable membrane, including one or more layers, covering the first open part of the receptacle; and (d) inserting the sample into the receptacle through the membrane, such that (1) the electroactive substance and (2) the sample, are in contact with each other and with said working electrode; wherein the electroactive substance is confined within the receptacle during step (d).Type: ApplicationFiled: June 29, 2005Publication date: November 8, 2007Inventors: Mark Hyland, John Broughall, Ronald Butler