Patents by Inventor Mark J. Hoekman

Mark J. Hoekman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of an L-alanine compound
    Patent number: 5268483
    Abstract: An improved process for the preparation of [1S-(1R*,2S*,3R*)]-N (4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4 thiazolyl)-N-[(1-cyclohexylmethyl) -2,3-dihydroxy-5-methylhexyl]-L-alaninamide is described where the key intermediate, 3-(2-amino 4-thiazolyl)-L-alanine is converted without protecting the aminothiazole group to the desired compound, as well as valuable intermediates used in the process.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: December 7, 1993
    Assignee: Warner-Lambert Company
    Inventors: Daniel T. Belmont, Valerie Hendrickson, Mark J. Hoekman
  • Process for the preparation of [1S-(1R*,2S*3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4- thiazolyl-N-[(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamid e
    Patent number: 5220031
    Abstract: An improved process for the preparation of [1S-(1R*,2S*,3R*) ]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-[(1-c yclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide is described where the key intermediate, 3-(2-amino-4-thiazolyl)-L-alanine is converted without protecting the aminothiazole group to the desired compound, as well as valuable intermediates used in the process.
    Type: Grant
    Filed: August 21, 1991
    Date of Patent: June 15, 1993
    Assignee: Warner-Lambert Company
    Inventors: Daniel T. Belmont, Valerie Henderickson, Mark J. Hoekman
  • Process for the preparation of [1S-(1R*,2S*,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4 -thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alanina mide
    Patent number: 5089616
    Abstract: An improved process for the preparation of [1S-(1R*,2S*,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-t hiazolyl)-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamid e is described where the key intermediate, 3-(2-amino-4-thiazolyl)-L-alanine is converted without protecting the aminothiazole group to the desired compound, as well as valuable intermediates used in the process.
    Type: Grant
    Filed: April 23, 1991
    Date of Patent: February 18, 1992
    Assignee: Warner-Lambert Company
    Inventors: Daniel T. Belmont, Valerie Hendrickson, Mark J. Hoekman