Patents by Inventor Mark J. Newman

Mark J. Newman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PAN-DR binding polypeptides and uses thereof
    Patent number: 9789181
    Abstract: The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AX1FVAAX2TLX3AX4A (SEQ ID NO:1), wherein X1 is H; X2 is selected from the group consisting of F, N, Y and W; X3 is H and X4 is selected from the group consisting of A, D and E. The invention also relates to large peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: October 17, 2017
    Assignee: EPIMMUNE INC.
    Inventors: Florence Dal Degan, Mark J. Newman, Jeffery L. Alexander, Scott Southwood
  • Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions
    Patent number: 9511134
    Abstract: The present invention provides polynucleotides and polypeptides capable of enhancing the immune response of a human in need of protection against influenza virus infection by administering in vivo, into a tissue of the human, at least one polynucleotide comprising one or more regions of nucleic acid encoding an influenza protein or a fragment, variant, or derivative thereof, or at least one polypeptide encoded therefrom. The present invention also relates to identifying and preparing influenza virus epitopes and to polynucleotides and polypeptides comprising such influenza virus epitopes. The present invention also relates to compositions and methods of use in the prevention and treatment of influenza virus infection.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: December 6, 2016
    Assignee: Epimmune Inc.
    Inventors: Jeffery L. Alexander, Pamuk A. Bilsel, Mark J. Newman
  • PAN-DR Binding Polypeptides and Uses Thereof
    Publication number: 20160114035
    Abstract: The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AX1FVAAX2TLX3AX4A (SEQ ID NO:1), wherein X1 is selected from the group consisting of W, F, Y, H, D, E, N, Q, I and K; X2 is selected from the group consisting of F, N, Y and W; X3 is selected from the group consisting of H and K, and X4 is selected from the group consisting of A, D and E, with the proviso that the oligopeptide sequence is not AKFVAAWTLKAAA. The invention also relates to larger peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.
    Type: Application
    Filed: December 22, 2015
    Publication date: April 28, 2016
    Applicant: Epimmune Inc.
    Inventors: Florence Dal Degan, Mark J. Newman, Jeffrey L. Alexander, Scott Southwood
  • Pan-DR binding polypeptides and uses thereof
    Patent number: 9249187
    Abstract: The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AX1FVAAX2TLX3AX4A (SEQ ID NO:1), wherein X1 is selected from the group consisting of W, F, Y, H, D, E, N, Q, I and K; X2 is selected from the group consisting of F, N, Y and W; X3 is selected from the group consisting of H and K, and X4 is selected from the group consisting of A, D and E, with the proviso that the oligopeptide sequence is not AKFVAAWTLKAAA. The invention also relates to larger peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: February 2, 2016
    Assignee: Epimmune Inc.
    Inventors: Florence Dal Degan, Mark J. Newman, Jeffery L. Alexander, Scott Southwood
  • PAN-DR Binding Polypeptides and Uses Thereof
    Publication number: 20110293646
    Abstract: The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AX1FVAAX2TLX3AX4A (SEQ ID NO:1), wherein X1 is selected from the group consisting of W, F, Y, H, D, E, N, Q, I and K; X2 is selected from the group consisting of F, N, Y and W; X3 is selected from the group consisting of H and K, and X4 is selected from the group consisting of A, D and E, with the proviso that the oligopeptide sequence is not AKFVAAWTLKAAA. The invention also relates to larger peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.
    Type: Application
    Filed: January 26, 2010
    Publication date: December 1, 2011
    Applicant: Epimmune Inc.
    Inventors: Florence Dal Degan, Mark J. Newman, Jeffery L. Alexander, Scott Southwood
  • Optimized multi-epitope constructs and uses thereof
    Patent number: 7888472
    Abstract: The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: February 15, 2011
    Assignees: Epimmune Inc., GENimmune N.V.
    Inventors: Alessandro Sette, Robert Chesnut, Mark J. Newman, Brian D. Livingston, Lilia Maria Babe, Yiyou Chen, Lawrence M. Deyoung, Manley T. F. Huang, Scott D. Power
  • Optimized Multi-Epitope Constructs and Uses Thereof
    Publication number: 20100068218
    Abstract: The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.
    Type: Application
    Filed: March 20, 2009
    Publication date: March 18, 2010
    Inventors: Alessandro SETTE, Robert Chesnut, Mark J. Newman, Brian D. Livingston, Lilia Marie Babe, Yiyou Chen, Lawrence M. Deyoung, Manley T.F. Huang, Scott D. Power
  • Method and System for Optimizing Minigenes and Peptides Encoded Thereby
    Publication number: 20100049491
    Abstract: The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of amino acid insertions at the junctions of the multi-epitope constructs so as to minimize the number of junctional epitopes and provide vaccines with increased immunogenicity.
    Type: Application
    Filed: December 8, 2008
    Publication date: February 25, 2010
    Inventors: Alessandro SETTE, Robert Chestnut, Brian D. Livingston, Denise Marie Baker, Mark J. Newman, David H. Brown
  • Induction of an immune response against streptococcus pneumoniae polyaccharides
    Publication number: 20090317412
    Abstract: The present invention provides conjugates of pan DR binding peptides with Streptococcus pneumoniae polysaccharides, and methods of preventing and treating diseases associated with Streptococcus pneumoniae infection with such conjugates.
    Type: Application
    Filed: June 3, 2005
    Publication date: December 24, 2009
    Inventors: Jeffery L. Alexander, Alessandro Sette, Mark J. Newman
  • Optimized multi-epitope constructs and uses thereof
    Patent number: 7507803
    Abstract: The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: March 24, 2009
    Assignee: Genimmune N.V.
    Inventors: Alessandro Sette, Robert Chesnut, Mark J. Newman, Brian D. Livingston, Lilia Maria Babe, Yiyou Chen, Lawrence M. Deyoung, Manley T. F. Huang, Scott D. Power
  • Method and system for optimizing minigenes and peptides encoded thereby
    Patent number: 7462354
    Abstract: The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of amino acid insertions at the junctions of the multi-epitope constructs so as to minimize the number of junctional epitopes and provide vaccines with increased immunogenicity.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: December 9, 2008
    Assignee: Pharmexa Inc.
    Inventors: Alessandro Sette, Robert Chesnut, Brian D. Livingston, Denise Marie Baker, Mark J. Newman
  • Method and system for optimizing multi-epitope nucleic acid constructs and peptides encoded thereby
    Publication number: 20040248113
    Abstract: The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of spacer nucleic acid at the junctions of the multi-epitope constructs encoding a plurality of CTL and/or HTL eoutioe oeotudes so as to minimize the number of junciontal epitopes and provide vaccines with increased immunogenicity.
    Type: Application
    Filed: June 8, 2004
    Publication date: December 9, 2004
    Inventors: Alessandro Sette, Robert Chesnut, Brian D Livingston, Denise Marie Baker, Mark J Newman, David H Brown
  • Method and system for optimizing minigenes and peptides encoded thereby
    Publication number: 20020119127
    Abstract: The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of amino acid insertions at the junctions of the multi-epitope constructs so as to minimize the number of junctional epitopes and provide vaccines with increased immunogenicity.
    Type: Application
    Filed: June 27, 2001
    Publication date: August 29, 2002
    Inventors: Alessandro Sette, Robert Chesnut, Brian D. Livingston, Denise Marie Baker, Mark J. Newman, David H. Brown