Patents by Inventor Mark J. Schofield

Mark J. Schofield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OPTIMIZING OPERATING BINDING CAPACITY FOR A MULTIPLE COLUMN CHROMATOGRAPHY PROCESS
    Publication number: 20240085388
    Abstract: Methods for optimizing operating binding capacity for a multiple column chromatography (MCC) process are disclosed.
    Type: Application
    Filed: November 10, 2023
    Publication date: March 14, 2024
    Inventors: Xhorxhi Gjoka, Karl K. Rogler, Mark J. Schofield
  • Optimizing operating binding capacity for a multiple column chromatography process
    Patent number: 11835501
    Abstract: Determining optimum operating binding capacity for a MCC process using one column, the process including N number of columns, comprises loading target product on a first column at a first residence time and/or flow rate; loading the product on the column at a second residence time and/or flow rate, the first residence time and/or flow rate being different than the second residence time and/or flow rate; generating a first breakthrough curve for the first residence time and/or flow rate and a second breakthrough curve for the second residence time and/or flow rate, wherein the first curve represents product breakthrough for the first column and the second curve represents product breakthrough for an Nth column; and using the curves to determine product loading capacity of the first column before product breakthrough at the Nth column; the product loading capacity of the first column equaling optimum operating binding capacity for the process.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: December 5, 2023
    Assignee: Sartorius Stedim Chromatography Systems Ltd.
    Inventors: Xhorxhi Gjoka, Karl K. Rogler, Mark J. Schofield
  • OPTIMIZING OPERATING BINDING CAPACITY FOR A MULTIPLE COLUMN CHROMATOGRAPHY PROCESS
    Publication number: 20170016864
    Abstract: Methods for optimizing operating binding capacity for a multiple column chromatography (MCC) process are disclosed.
    Type: Application
    Filed: July 13, 2015
    Publication date: January 19, 2017
    Inventors: Xhorxhi Gjoka, Karl K. Rogler, Mark J. Schofield