Abstract: A system and method for filtering a pressure signal in a medical device in which a sensor terminal senses the pressure signal, an electrode terminal receives cardiac electrical signals, a signal filtering system filters the sensed pressure signal in response to a determined heart rate to generate a heart-rate dependent frequency response, and a microprocessor derives a respiration signal in response to the heart rate dependent frequency response, and determines metrics of hemodynamic function in response to the derived respiration signal.

Abstract: An implantable medical device and associated method detect obstructed inspiration by monitoring an blood pressure signal. A respiration signal is monitored and a phase of respiratory inspiration is detected from the respiration signal. A trend in the pressure signal is measured during the inspiration phase. Obstructed inspiration for the inspiration phase is detected in response to the measured the trend.

Abstract: A system and method for monitoring in a patient includes producing sensor signals representative of a physiologic parameter associated with respiration. A periodic breathing cycle is detected based on the sensor signals. An output is produced as a function of the cycle length.

Abstract: An apparatus for determining a respiration parameter in a medical device in which a pressure sensor senses pressure signals, and a signal processor, coupled to the pressure sensor, receives the sensed pressure signals and generates corresponding sample points.

Abstract: A medical device for determining a respiratory effort having a pressure sensor to sense pressure signals, a housing having system components positioned therein, and a microprocessor positioned within the housing, wherein the microprocessor detects an inspiration and an expiration in response to the pressure signals, detects a breath in response to the detected inspiration and the detected expiration, and determines the respiratory effort in response to the detected breath.

Abstract: A system and method for filtering a pressure signal in a medical device in which a sensor terminal senses the pressure signal, an electrode terminal receives cardiac electrical signals, a signal filtering system filters the sensed pressure signal in response to a determined heart rate to generate a heart-rate dependent frequency response, and a microprocessor derives a respiration signal in response to the heart rate dependent frequency response, and determines metrics of hemodynamic function in response to the derived respiration signal.

Abstract: A method of determining a respiration parameter in a medical device in which pressure signals are sensed to generate corresponding sample points, and a breath detection threshold is continuously adjusted in response to the generated sample points to generate a current adjusted breath detection threshold. A current generated sample point is compared to the current adjusted breath detection threshold, and the continuous adjusting of the breath detection threshold is suspended and the breath detection threshold is equal to the most current adjusted breath detection threshold generated prior to the suspending in response to the comparing. A next sample point, generated subsequent to the suspending, is compared to the set breath detection threshold, and the respiration parameter is determined in response to the comparing of a next sample point to the set breath detection threshold.

Abstract: A method of determining respiratory effort in a medical device in which pressure signals are sensed to generate corresponding sample points, an inspiration and an expiration are detected in response to the sensed pressure signals, a breath is detected in response to the detected inspiration and the detected expiration, and the respiratory effort is determined in response to the detected breath.

Abstract: A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.

Abstract: Oxygen saturation data is monitored during a predefined window to obtain a measurement of circulation delay. The measured circulation delay is used as a basis for determining therapies, including overdrive pacing. In some embodiments, circulation delay is used to identify patients that will benefit from overdrive pacing as a therapy for sleep disordered breathing.

Abstract: A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.

Abstract: The invention relates generally to a system and method for monitoring and automatically delivering a therapy for sleep-related disordered breathing. In one form the present invention relates to an external device for monitoring for sleep-related disordered breathing in communication with an implantable medical device for delivering an electrical stimulation therapy. In another form the present invention relates to an implantable medical device for detecting sleep-related disordered breathing episode(s) and an external apparatus (e.g., a CPAP machine) for providing therapy to terminate, and/or reduce, said episode(s). In this form of the invention, the implantable medical device communicates with the external apparatus so that the therapy provided corresponds in magnitude and duration to the severity and/or length of the episode(s).

Abstract: A method and apparatus for cardiac pacing are provided in which pacing pulses are delivered at an increased rate in response to a detected intrinsic heart rate drop and a special rate drop response detection scheme is temporarily disabled until an intrinsic heart rate exceeds a predetermined threshold value. If the pacing rate reaches the lower pacing rate without sensing intrinsic activity, heart rate drop detection remains disabled and lower rate pacing continues. Rate drop detection is re-enabled whenever sufficient sensed intrinsic activity indicates that a sudden intrinsic rate drop could occur again. Thus, the subsequent reduction in heart rate requiring therapy is declared only if a sensed intrinsic heart rate drops from above an intermediate value (herein defined as a re-enable rate) that is set above the lower pacing rate and an upper pacing rate.

Abstract: The present invention relates to methods and apparatus for detection and treatment of syncope in an implantable medical device, and particularly to detection of syncope as a function of a predetermined increase in one or more respiration parameter and drop in heart rate and optionally delivering a pacing therapy in response thereto. The onset of a syncopal episode is declared when the patient's respiration rate and/or tidal volume and/or minute ventilation increases by a predetermined increment or threshold and a heart rate drops below a threshold heart rate drop. The threshold heart rate drop is preferably established as a function of the change in the respiration parameter.

Abstract: A method and apparatus for cardiac pacing are provided in which pacing pulses are delivered at an increased rate in response to a detected intrinsic heart rate drop and a special rate drop response detection scheme is temporarily disabled until an intrinsic heart rate exceeds a predetermined threshold value. If the pacing rate reaches the lower pacing rate without sensing intrinsic activity, heart rate drop detection remains disabled and lower rate pacing continues. Rate drop detection is re-enabled whenever sufficient sensed intrinsic activity indicates that a sudden intrinsic rate drop could occur again. Thus, the subsequent reduction in heart rate requiring therapy is declared only if a sensed intrinsic heart rate drops from above an intermediate value (herein defined as a re-enable rate) that is set above the lower pacing rate and an upper pacing rate.

Abstract: A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.

Abstract: The invention relates generally to a system and method for monitoring and automatically delivering a therapy for sleep-related disordered breathing. In one form the present invention relates to an external device for monitoring for sleep-related disordered breathing in communication with an implantable medical device for delivering an electrical stimulation therapy. In another form the present invention relates to an implantable medical device for detecting sleep-related disordered breathing episode(s) and an external apparatus (e.g., a CPAP machine) for providing therapy to terminate, and/or reduce, said episode(s). In this form of the invention, the implantable medical device communicates with the external apparatus so that the therapy provided corresponds in magnitude and duration to the severity and/or length of the episode(s).

Abstract: The present invention provides a method and apparatus for detecting and treating sleep respiratory events that includes a plurality of sensors gathering physiological data related to sleep respiratory events. A processor extracts an average cycle length and a frequency of at least one of Cheyne-Stokes respiration and periodic breathing based upon the physiological data, and determines whether therapy is required based on the average cycle length and the frequency.

Abstract: The present invention provides a method and apparatus for detecting and treating sleep respiratory events that includes a plurality of sensors gathering physiological data related to sleep respiratory events. A processor extracts an average cycle length and a frequency of at least one of Cheyne-Stokes respiration and periodic breathing based upon the physiological data, and determines whether therapy is required based on the average cycle length and the frequency.

Abstract: The present invention relates to methods and apparatus for detection and treatment of syncope in an implantable medical device, and particularly to detection of syncope as a function of a predetermined increase in one or more respiration parameter and drop in heart rate and optionally delivering a pacing therapy in response thereto. The onset of a syncopal episode is declared when the patient's respiration rate and/or tidal volume and/or minute ventilation increases by a predetermined increment or threshold and a heart rate drops below a threshold heart rate drop. The threshold heart rate drop is preferably established as a function of the change in the respiration parameter.