Abstract: Systems and methods are provided for vacuum spray drying. In one example, a method for spray drying includes estimating an outlet temperature to achieve a minimum drying rate at atmospheric pressure based on a selected liquid feed and a selected liquid to gas ratio, calculating a predicted dryer pressure at which the minimum drying rate can be reached at a reduced outlet temperature, and spray drying the selected liquid feed at the selected liquid to gas ratio, the predicted dryer pressure and the reduced outlet temperature. The reduced outlet temperature is less than a maximum temperature and the predicted dryer pressure includes an approximation for droplet solidification.

Abstract: Pharmaceutical formulations, methods for spray drying pharmaceutical formations, and systems for spray drying pharmaceutical formulation are provided. In one example, a method for spray drying a pharmaceutical formulation may include selecting a solvent mixture comprising a low volatility solvent based on a solubility of a drug of the pharmaceutical formulation in the solvent mixture, forming a solution of the drug of the pharmaceutical formulation in the solvent mixture, and spray drying the solution using a spray drying mass ratio that is selected based on a relationship between a glass transition temperature of the pharmaceutical formulation and a relative saturation of the low volatility solvent during the spray drying, the spray drying mass ratio defining a liquid feed rate of the solution to a gas feed rate of a drying gas, and using a process outlet temperature that is less than the glass transition temperature of the pharmaceutical formulation.

Abstract: Disclosed are compositions and methods related to clot-binding head groups. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.

Abstract: The deposition of chitosan onto electrode surfaces is disclosed. Methods of depositing chitosan on surfaces are disclosed. Materials comprising chitosan deposited on a substrate are also disclosed.

Abstract: A micro-electro-mechanical system (MEMS) device is provided, along with means for its fabrication and operation for microfluidic and/or biomicrofluidic applications. The MEMS device includes a substrate, optional electrodes on the substrate, a patterned structure on the substrate, the patterned structure having a fluidic microchannel aligned with one or more of the optional electrodes, an encapsulation membrane covering the microchannel, and an optional reactive layer deposited over the electrode in the microchannel. MEMS devices of preferred embodiments permit a leak-tight seal to be formed around the microchannel and fluidic interconnects established for robust operation of fluidics-based processes. MEMS devices of other preferred embodiments permit reversible attachment and separation of the encapsulation membrane relative to the patterned structure.