Patents by Inventor Mark Knuth
Mark Knuth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240092918Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.Type: ApplicationFiled: February 3, 2023Publication date: March 21, 2024Inventors: Steven BENDER, Tracy CHARLTON, Anna GALKIN, Bernhard Hubert GEIERSTANGER, Scott Martin GLASER, Shailaja KASIBHATLA, Mark KNUTH, Sabine ROTTMANN, Sarah RUE, Glen SPRAGGON, Tetsuo UNO
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Patent number: 11634497Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.Type: GrantFiled: February 1, 2018Date of Patent: April 25, 2023Assignee: NOVARTIS AGInventors: Steven Bender, Tracy Charlton, Anna Galkin, Bernhard Hubert Geierstanger, Scott Martin Glaser, Shailaja Kasibhatla, Mark Knuth, Sabine Rottmann, Sarah Rue, Glen Spraggon, Tetsuo Uno
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Publication number: 20220127321Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.Type: ApplicationFiled: August 26, 2021Publication date: April 28, 2022Inventors: Michael DiDonato, Bernhard Hubert Geierstanger, Tobias Junt, Mark Knuth, Shelly Meeusen, Carolina Nicole Simpson, Glen Spraggon, John Trauger
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Patent number: 11136366Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.Type: GrantFiled: October 18, 2018Date of Patent: October 5, 2021Assignee: Novartis AGInventors: Michael DiDonato, Bernhard Hubert Geierstanger, Tobias Junt, Mark Knuth, Shelly Meeusen, Carolina Nicole Simpson, Glen Spraggon, John Trauger
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Publication number: 20210010013Abstract: The present disclosure provides fatty acid desaturase 2 (FAD2) genes and plants and/or plant cells bearing one or more mutations in two or more FAD2 genes; as well as methods of making and using such plants. In some embodiments, plants producing seed oil with high oleic acid content are provided.Type: ApplicationFiled: April 4, 2019Publication date: January 14, 2021Applicants: Cibus US LLC, Cibus Europe, B.V.Inventors: Gregory F.W. GOCAL, Mark KNUTH
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Publication number: 20200216548Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.Type: ApplicationFiled: February 1, 2018Publication date: July 9, 2020Inventors: Steven BENDER, Tracy CHARLTON, Anna GALKIN, Bernhard Hubert GEIERSTANGER, Scott Martin GLASER, Shailaja KASIBHATLA, Mark KNUTH, Sabine ROTTMANN, Sarah RUE, Glen SPRAGGON, Tetsuo UNO
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Publication number: 20190241636Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.Type: ApplicationFiled: October 18, 2018Publication date: August 8, 2019Inventors: Michael DiDonato, Bernhard Hubert Geierstanger, Tobias Junt, Mark Knuth, Shelly Meeusen, Carolina Nicole Simpson, Glen Spraggon, John Trauger
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Patent number: 10144768Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.Type: GrantFiled: December 1, 2016Date of Patent: December 4, 2018Assignee: Novartis AGInventors: Michael DiDonato, Bernhard Hubert Geierstanger, Tobias Junt, Mark Knuth, Shelly Meeusen, Carolina Nicole Simpson, Glen Spraggon, John Trauger
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Patent number: 9796938Abstract: Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plant are increased. Further provided is a method of predicting the melting point of a blend of fatty acid methyl esters and the use of such a method for identifying blends suitable for use as, for example, a biodiesel.Type: GrantFiled: January 28, 2013Date of Patent: October 24, 2017Assignee: NUCELIS INC.Inventors: Mark Knuth, Peter R. Beetham, Keith Walker, Greg F. W. Gocal
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Publication number: 20170158747Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.Type: ApplicationFiled: December 1, 2016Publication date: June 8, 2017Inventors: Michael DIDONATO, Mark KNUTH, Shelly MEEUSEN, Glen SPRAGGON
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Publication number: 20170051219Abstract: Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plant are increased. Further provided is a method of predicting the melting point of a blend of fatty acid methyl esters and the use of such a method for identifying blends suitable for use as, for example, a biodiesel.Type: ApplicationFiled: January 28, 2013Publication date: February 23, 2017Inventors: Mark Knuth, Peter R. Beetham, Keith Walker, Greg F.W. Gocal
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Patent number: 8361173Abstract: Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plant are increased. Further provided is a method of predicting the melting point of a blend of fatty acid methyl esters and the use of such a method for identifying blends suitable for use as, for example, a biodiesel.Type: GrantFiled: September 7, 2011Date of Patent: January 29, 2013Assignee: Nucelis Inc.Inventors: Mark Knuth, Peter R. Beetham, Keith Walker, Greg F. W. Gocal
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Publication number: 20120073186Abstract: Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plant are increased. Further provided is a method of predicting the melting point of a blend of fatty acid methyl esters and the use of such a method for identifying blends suitable for use as, for example, a biodiesel.Type: ApplicationFiled: September 7, 2011Publication date: March 29, 2012Inventors: Mark Knuth, Peter R. Beetham, Keith Walker, Greg F. W. Gocal
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Patent number: 8029579Abstract: Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plant are increased. Further provided is a method of predicting the melting point of a blend of fatty acid methyl esters and the use of such a method for identifying blends suitable for use as, for example, a biodiesel.Type: GrantFiled: June 27, 2007Date of Patent: October 4, 2011Assignee: COH Inc.Inventors: Mark Knuth, Peter R. Beetham, Keith A. Walker, Gregory Francis William Gocal
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Publication number: 20110003736Abstract: The subject invention concerns new classes of pesticidally active proteins and the polynucleotide sequences that encode these proteins. In preferred embodiments, these pesticidal proteins have molecular weights of approximately 40-50 kDa and of approximately 10-15 kDa.Type: ApplicationFiled: June 30, 2010Publication date: January 6, 2011Applicant: Mycogen CorporationInventors: Kenneth E. Narva, H. Ernest Schnepf, Mark Knuth, Michael R. Pollard, Guy A. Cardineau, George E. Schwab, Tracy Ellis Michaels, Stacey Finstad Lee, Paula Diehl, Joanna Dojillo, Lisa Stamp, Rod Herman
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Patent number: 7790961Abstract: The subject invention concerns new classes of pesticidally active proteins and the polynucleotide sequences that encode these proteins. In preferred embodiments, these pesticidal proteins have molecular weights of approximately 40-50 kDa and of approximately 10-15 kDa.Type: GrantFiled: June 29, 2007Date of Patent: September 7, 2010Assignee: Hycogen CorporationInventors: Kenneth E. Narva, H. Ernest Schnepf, Mark Knuth, Michael R. Pollard, Guy A. Cardineau, George E. Schwab, Tracy Ellis Michaels
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Patent number: 7355003Abstract: The subject invention concerns new classes of pesticidally active proteins and the polynucleotide sequences which encode these proteins. More specifically, in preferred embodiments, pesticidal proteins of approximately 40-50 kDa and of approximately 10-15 kDa are used for controlling corn rootworms. Also described are novel pesticidal isolates of Bacillus thuringiensis.Type: GrantFiled: January 18, 2005Date of Patent: April 8, 2008Assignee: Mycogen CorporationInventors: Kenneth E. Narva, H. Ernest Schnepf, Mark Knuth, Michael R. Pollard, Guy A. Cardineau, George E. Schwab, Tracy Ellis Michaels
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Publication number: 20070265205Abstract: The subject invention concerns new classes of pesticidally active proteins and the polynucleotide sequences that encode these proteins. In preferred embodiments, these pesticidal proteins have molecular weights of approximately 40-50 kDa and of approximately 10-15 kDa.Type: ApplicationFiled: June 29, 2007Publication date: November 15, 2007Inventors: Kenneth Narva, H. Schnepf, Mark Knuth, Michael Pollard, Guy Cardineau, George Schwab, Tracy Michaels, Stacey Lee, Paula Diehl, Joanna Dojillo, Lisa Stamp, Rod Herman
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Patent number: 7247613Abstract: The subject invention concerns new classes of pesticidally active proteins and the polynucleotide sequences that encode these proteins. In preferred embodiments, these pesticidal protein have molecular weights of approximately 40–50 kDa and of approximately 10–15 kDa.Type: GrantFiled: December 19, 2003Date of Patent: July 24, 2007Assignee: Mycogen CorporationInventors: Kenneth E. Narva, H. Ernest Schnepf, Mark Knuth, Michael R. Pollard, Guy A. Cardineau, George E. Schwab, Tracy Ellis Michaels, Stacey Finstad Lee, Paula Diehl, Joanna Dojillo, Lisa Stamp, Rod Herman
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Publication number: 20050155112Abstract: The subject invention concerns new classes of pesticidally active proteins and the polynucleotide sequences which encode these proteins. More specifically, in preferred embodiments, pesticidal proteins of approximately 40-50 kDa and of approximately 10-15 kDa are used for controlling corn rootworms. Also described are novel pesticidal isolates of Bacillus thuringiensis.Type: ApplicationFiled: January 18, 2005Publication date: July 14, 2005Applicant: Mycogen CorporationInventors: Kenneth Narva, H. Schnepf, Mark Knuth, Michael Pollard, Guy Cardineau, George Schwab, Tracy Michaels, Stacey Lee, Paula Burmeister, Joanna Dojillo