Patents by Inventor Mark L. Chivers

Mark L. Chivers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Clarification of protein precipitate suspensions using anionic polymeric flocculants
    Patent number: 6927282
    Abstract: Protein suspensions comprising soluble and insoluble components are purified via flocculation with anionic polymers, such as polyacrylamides, potato starch, or modified cellulose. The procedure improves the efficiency of solid/liquid separations and can minimize or eliminate the requirement for centrifugation and/or filtration in large scale biotechnological processes. The method is particularly well suited for the purification and clarification of protein suspensions containing soluble somatotropin monomer using polyacrylamide and polysaccharide flocculants.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: August 9, 2005
    Assignees: Monsanto Technology LLC, Cytec Technology Corp.
    Inventors: Mark L. Chivers, Algird S. Cibulskas
  • Clarification of protein precipitate suspensions using anionic polymeric flocculants
    Publication number: 20020058786
    Abstract: Protein suspensions comprising soluble and insoluble components are purified via flocculation with anionic polymers, such as polyacrylamides, potato starch, or modified cellulose. The procedure improves the efficiency of solid/liquid separations and can minimize or eliminate the requirement for centrifugation and/or filtration in large scale biotechnological processes. The method is particularly well suited for the purification and clarification of protein suspensions containing soluble somatotropin monomer using polyacrylamide and polysaccharide flocculants.
    Type: Application
    Filed: August 27, 2001
    Publication date: May 16, 2002
    Applicant: MONSANTO TECHNOLOGY LLC.
    Inventor: Mark L. Chivers
  • Clarification of protein precipitate suspensions using anionic polymeric flocculants
    Patent number: 6307013
    Abstract: Protein suspensions comprising soluble and insoluble components are purified via flocculation with anionic polymers, such as polyacrylamides, potato starch, or modified cellulose. The procedure improves the efficiency of solid/liquid separations and can minimize or eliminate the requirement for centrifugation and/or filtration in large scale biotechnological processes. The method is particularly well suited for the purification and clarification of protein suspensions containing soluble somatotropin monomer using polyacrylamide and polysaccharide flocculants.
    Type: Grant
    Filed: July 16, 1999
    Date of Patent: October 23, 2001
    Assignee: Monsanto Technology LLC
    Inventor: Mark L. Chivers
  • Nickel-free hemoglobin and methods for producing such hemoglobin
    Patent number: 5578564
    Abstract: According to the present invention removal of nickel from a nickel-containing hemoglobin solution is accomplished by exposing the nickel-containing hemoglobin solution to a chelating agent, preferably a multidentate acetic acid based chelator such as EDTA. Methods are provided that allow obtaining essentially nickel-free hemoglobin from nickel-containing hemoglobin solutions, particularly hemoglobin solutions that result from large scale fermentation and/or purification.
    Type: Grant
    Filed: July 23, 1993
    Date of Patent: November 26, 1996
    Assignee: Somatogen, Inc.
    Inventors: Mark L. Chivers, Thomas K. Belval