Patents by Inventor Mark L. Nelson

Mark L. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 9-Aminomethyl Substituted Minocycline Compounds
    Publication number: 20100113400
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: May 28, 2009
    Publication date: May 6, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • 7,8 and 9-substituted tetracycline compounds
    Patent number: 7696188
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: April 13, 2010
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza, Glen Rennie
  • Methods of preparing substituted tetracyclines with transition metal-based chemistries
    Patent number: 7696187
    Abstract: The present invention relates to 9-substituted tetracycline derivatives as well as compositions and use thereof.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: April 13, 2010
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
  • 7,9-substituted tetracycline compounds
    Patent number: 7696186
    Abstract: The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: April 13, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Laura McIntyre, Beena Bhatia, Paul Hawkins, Laxma Reddy, Karen Stapleton, Tadeusz Warchol, Paul Sheahan
  • 9-AMINOACYL TETRACYCLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20100075929
    Abstract: A compound of formula (I):
    Type: Application
    Filed: November 24, 2009
    Publication date: March 25, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Carmen García-Luzón, Juan Carlos Cuevas, Jose M. Fiandor, Araceli Mallo, Mark L. Nelson, Roger Frechette
  • 9-aminoacyl tetracycline compounds and methods of use thereof
    Patent number: 7652002
    Abstract: A compound of formula (I):
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: January 26, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Carmen García-Luzón, Juan Carlos Cuevas, Jose M. Fiandor, Araceli Mallo, Mark L. Nelson, Roger Frechette
  • 7-N-Substituted Phenyl Tetracycline Compounds
    Publication number: 20100004211
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Application
    Filed: January 21, 2009
    Publication date: January 7, 2010
    Inventors: Mark L. Nelson, Darrell J. Koza
  • 9-SUBSTITUTED MINOCYCLINE COMPOUNDS
    Publication number: 20090325908
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: January 9, 2009
    Publication date: December 31, 2009
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura Honeyman, Tadeusz Warchol, David Messersmith
  • 7-SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20090306022
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 9, 2009
    Publication date: December 10, 2009
    Applicants: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
  • 7-Substituted fused ring tetracycline compounds
    Patent number: 7612053
    Abstract: 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: November 3, 2009
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Laura McIntyre
  • METHODS OF REGULATING EXPRESSION OF GENES OR OF GENE PRODUCTS USING SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20090257985
    Abstract: The present invention relates, at least in part, to the use of substituted tetracycline compounds for regulation of expression of nucleic acids operably linked to a tetracycline operator system. The invention pertains to compounds used in a regulatory system which utilizes components of the Tet repressor/operator/inducer system of prokaryotes to regulate gene expression in cells. Use of certain substituted tetracycline compounds, as featured in the methods of the invention, result in improved dose-response results when compared to those for e.g., tetracycline and doxycycline. Certain methods of the invention thus allow for enhanced control of the Tet repressor/operator/inducer system in regulating gene expression in cells.
    Type: Application
    Filed: September 19, 2008
    Publication date: October 15, 2009
    Inventors: Mark L. Nelson, Hermann Bujard
  • 7-Phenyl-Substituted Tetracycline Compounds
    Publication number: 20090258842
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Application
    Filed: April 17, 2009
    Publication date: October 15, 2009
    Applicant: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell Koza
  • 7-substituted tetracycline compounds
    Patent number: 7595309
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: September 29, 2009
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Beena Bhatia, David Messersmith, Mohamed Y. Ismail, Todd Bowser, Laura McIntyre, Darrell J. Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul K. Verma, Tadeusz Warchol, Upul Bandarage
  • 9-aminomethyl substituted minocycline compounds
    Patent number: 7553828
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: June 30, 2009
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • MOTOR FUEL ADDITIVE COMPOSITION
    Publication number: 20090158643
    Abstract: Disclosed is a leaded motor fuel additive composition which synergistically interacts with the alkyl lead additive to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
    Type: Application
    Filed: March 5, 2009
    Publication date: June 25, 2009
    Applicant: POLAR MOLECULAR CORPORATION
    Inventors: Otis L. Nelson, JR., Mark L. Nelson, A. Richard Nelson, Chandra Prakash, Gilbert Chapelet
  • MOTOR FUEL ADDITIVE COMPOSITION
    Publication number: 20090158642
    Abstract: Disclosed is a MMT containing motor fuel additive composition which synergistically interacts with the MMT additive to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
    Type: Application
    Filed: March 5, 2009
    Publication date: June 25, 2009
    Applicant: POLAR MOLECULAR CORPORATION
    Inventors: Otis L. Nelson, JR., Mark L. Nelson, A. Richard Nelson, Chandra Prakash, Gilbert Chapelet
  • 7-N-substituted phenyl tetracycline compounds
    Publication number: 20090124583
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Application
    Filed: May 30, 2008
    Publication date: May 14, 2009
    Applicant: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell Koza
  • Methods for Treating Spinal Muscular Atrophy Using Tetracycline Compounds
    Publication number: 20090118269
    Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
    Type: Application
    Filed: April 14, 2008
    Publication date: May 7, 2009
    Inventors: Joel Berniac, Todd Bowser, Michael Draper, Stuart B. Levy, Mark L. Nelson
  • 7-phenyl-substituted tetracycline compounds
    Patent number: 7521437
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: April 21, 2009
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
  • 7-Phenyl-Substituted Tetracycline Compounds
    Publication number: 20080306032
    Abstract: 7-phenyl-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. 7-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Application
    Filed: July 31, 2008
    Publication date: December 11, 2008
    Inventors: Mark L. Nelson, Mohamed Y. Ismail