Patents by Inventor Mark L. Stahl

Mark L. Stahl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying agents that interact with MAP kinase activated protein kinase 2
    Patent number: 7167802
    Abstract: This invention is directed to the crystal structures of MK2, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of MK2 proteins. Such agents may be useful as therapeutic agents.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: January 23, 2007
    Assignee: Wyeth
    Inventors: Kevin D. Parris, Kathryn W. Underwood, Mark L. Stahl, Lidia Mosyak, Kristine Svenson, Tania Shane, Meggin L. Taylor
  • Crystal structure of yqeJ and uses thereof
    Patent number: 7155346
    Abstract: This invention is directed to the crystal structure of yqeJ, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of yqeJ. Such agents may be useful as antibacterial agents.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: December 26, 2006
    Assignees: Wyeth, Millennium Pharmaceuticals, Inc.
    Inventors: Andrea M. Olland, Mark L. Stahl, Francis X. Sullivan, Kathryn W. Underwood, Rajiv Chopra
  • Crystal structure of cPLA2 and methods of identifying agonists and antagonists using same
    Patent number: 6801860
    Abstract: The present invention provides for crystalline cPLA2. The crystal structure of cPLA2 has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of cPLA2 activity and membrane binding using such models are also disclosed.
    Type: Grant
    Filed: February 15, 1999
    Date of Patent: October 5, 2004
    Assignee: Genetics Institute, LLC
    Inventors: Andrea Dessen, William S. Somers, Mark L. Stahl, Jasbir S. Seehra
  • Crystal structures of MK2 and uses thereof
    Publication number: 20040091872
    Abstract: This invention is directed to the crystal structures of MK2, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of MK2 proteins. Such agents may be useful as therapeutic agents.
    Type: Application
    Filed: November 13, 2002
    Publication date: May 13, 2004
    Inventors: Kevin D. Parris, Kathryn W. Underwood, Mark L. Stahl, Lidia Mosyak, Kristine Svenson, Tania Shane, Meggin L. Taylor
  • Crystal structure of yqeJ and uses thereof
    Publication number: 20030124699
    Abstract: This invention is directed to the crystal structure of yqeJ, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of yqeJ. Such agents may be useful as antibacterial agents.
    Type: Application
    Filed: July 31, 2002
    Publication date: July 3, 2003
    Inventors: Andrea M. Olland, Mark L. Stahl, Francis X. Sullivan, Kathryn W. Underwood, Rajiv Chopra
  • Crystalline IL-6 and models of the molecular structure of IL-6
    Publication number: 20030068300
    Abstract: Crystallographic and NMR solution structures of human IL-6 are reported. The invention provides models and systems incorporating such structures which are useful for identifying IL-6/IL-6 receptor interactions and for identification of agonists and antagonists of such interactions. Crystalline human IL-6 is also provided.
    Type: Application
    Filed: September 19, 2002
    Publication date: April 10, 2003
    Applicant: Wyeth
    Inventors: William S. Somers, Mark L. Stahl, Jasbir S. Seehra, Guang-Yi Xu, Thomas E. McDonagh, Hsiang-Ai Yu, Jin Hong
  • Crystalline IL-6 and models of the molecular structure of IL-6
    Patent number: 6461604
    Abstract: Crystallographic and NMR solution structures of human IL-6 are reported. The invention provides models and systems incorporating such structures which are useful for identifying IL-6/IL-6 receptor interactions and for identification of agonists and antagonists of such interactions. Crystalline human IL-6 is also provided.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: October 8, 2002
    Assignee: Genetics Institute, LLC
    Inventors: William S. Somers, Mark L. Stahl, Jasbir S. Seehra, Guang-Yi Xu, Thomas E. McDonagh, Hsiang-Ai Yu, Jin Hong
  • Crystal structure of E. coli GDP-fucose synthetase (and complexes thereof) and methods of identifying agonists and antagonists using same
    Patent number: 6459996
    Abstract: The present invention provides for crystalline GFS. The crystal structure of GFS has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of GFS activity using such models are also disclosed.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: October 1, 2002
    Assignee: American Home Products Corporation
    Inventors: William S. Somers, Mark L. Stahl, Francis X. Sullivan
  • Protease deficient bacillus
    Patent number: 5264366
    Abstract: There are described, normally sporulating mutant Bacillus strain(s) which produce no detectable proteolytic activity during any phase of its growth. The absence of detectable proteolytic activity is due to the deletion of one or more codons specifying the mature subtilisin protease and the mature neutral protease. Also described are methods for producing such normally sporulating, protease deficient Bacillus mutants.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: November 23, 1993
    Assignee: Genencor, Inc.
    Inventors: Eugenio Ferrari, Dennis J. Henner, Mark L. Stahl
  • Method for producing heterologous proteins
    Patent number: 4801536
    Abstract: This invention concerns a method for producing a heterologous protein in a bacterial host cell such that the protein is exported from the host cell into the culture medium. The method involves culturing in a bacterial culture medium a genetically engineered bacterial strain containing a fusion DNA sequence comprising a first nucleotide sequence encoding at least an N-terminal portion of a flagellin protein and a second nucleotide sequence encoding the heterologous protein. The first nucleotide sequence is linked via its 3' terminus to the 5' terminus of the second nucleotide sequence, and the fusion DNA sequence is itself linked to an expression control sequence.
    Type: Grant
    Filed: June 2, 1987
    Date of Patent: January 31, 1989
    Assignee: Genetics Institute, Inc.
    Inventors: Mark L. Stahl, Edward R. LaVallie