Abstract: A coherency manager for receiving snoop requests addressed in a physical address space, the snoop requests relating to a cache memory addressable using a virtual address space, the cache memory having a plurality of coherent cachelines, the coherency manager comprising: a reverse translation module configured to maintain a mapping from physical addresses to virtual addresses for each coherent cacheline held in the cache memory; and a snoop processor configured to: receive a snoop request relating to a physical address; in response to the received snoop request, determine whether the physical address is mapped to a virtual address in the reverse translation module; and process the snoop request in dependence on that determination.

Abstract: A memory interface for interfacing between a memory bus and a cache memory, comprising: a plurality of bus interfaces configured to transfer data between the memory bus and the cache memory; and a plurality of snoop processors configured to receive snoop requests from the memory bus; wherein each snoop processor is associated with a respective bus interface and each snoop processor is configured, on receiving a snoop request, to determine whether the snoop request relates to the bus interface associated with that snoop processor and to process the snoop request in dependence on that determination.

Abstract: A converter module is described which handles memory requests issued by a cache (e.g. an on-chip cache), where these memory requests include memory addresses defined within a virtual memory space. The converter module receives these requests, issues each request with a transaction identifier and uses that identifier to track the status of the memory request. The converter module sends requests for address translation to a memory management unit and where there the translation is not available in the memory management unit receives further memory requests from the memory management unit. The memory requests are issued to a memory via a bus and the transaction identifier for a request is freed once the response has been received from the memory. When issuing memory requests onto the bus, memory requests received from the memory management unit may be prioritized over those received from the cache.

Abstract: Disclosed are devices for pericardial access to the heart, including direct access to the left atrium. In certain embodiments, the device may comprise a device and/or an atrial appendage (AA) portal having a configuration such that the distal end of the device and/or the portal can access an atrial appendage while the proximal end of the device and/or portal can extend to outside of the subject. The devices and methods may also include a pericardial portal for emplacement of the device and/or the AA portal. Also, methods for using such devices and/or AA portals and pericardial portals to perform surgery on the heart, and systems (e.g., kits) comprising these devices and/or portals in combination with other therapeutic devices are disclosed.

Abstract: A converter module is described which handles memory requests issued by a cache (e.g. an on-chip cache), where these memory requests include memory addresses defined within a virtual memory space. The converter module receives these requests, issues each request with a transaction identifier and uses that identifier to track the status of the memory request. The converter module sends requests for address translation to a memory management unit and where there the translation is not available in the memory management unit receives further memory requests from the memory management unit. The memory requests are issued to a memory via a bus and the transaction identifier for a request is freed once the response has been received from the memory. When issuing memory requests onto the bus, memory requests received from the memory management unit may be prioritized over those received from the cache.

Abstract: The disclosure provides methods correlating intra-patient genomic heterogeneity of single CTCs with phenotypic heterogeneity in each of a population of prostate cancer (PCa) patients.

Abstract: An on-chip cache is described which receives memory requests and in the event of a cache miss, the cache generates memory requests to a lower level in the memory hierarchy (e.g. to a lower level cache or an external memory). Data returned to the on-chip cache in response to the generated memory requests may be received out-of-order. An instruction scheduler in the on-chip cache stores pending received memory requests and effects the re-ordering by selecting a sequence of pending memory requests for execution such that pending requests relating to an identical cache line are executed in age order and pending requests relating to different cache lines are executed in an order dependent upon when data relating to the different cache lines is returned. The memory requests which are received may be received from another, lower level on-chip cache or from registers.

Abstract: A converter module is described which handles memory requests issued by a cache (e.g. an on-chip cache), where these memory requests include memory addresses defined within a virtual memory space. The converter module receives these requests, issues each request with a transaction identifier and uses that identifier to track the status of the memory request. The converter module sends requests for address translation to a memory management unit and where there the translation is not available in the memory management unit receives further memory requests from the memory management unit. The memory requests are issued to a memory via a bus and the transaction identifier for a request is freed once the response has been received from the memory. When issuing memory requests onto the bus, memory requests received from the memory management unit may be prioritized over those received from the cache.

Abstract: Disclosed are devices for pericardial access to the heart, including direct access to the left atrium. In certain embodiments, the device may comprise a device and/or an atrial appendage (AA) portal having a configuration such that the distal end of the device and/or the portal can access an atrial appendage while the proximal end of the device and/or portal can extend to outside of the subject. The devices and methods may also include a pericardial portal for emplacement of the device and/or the AA portal. Also, methods for using such devices and/or AA portals and pericardial portals to perform surgery on the heart, and systems (e.g., kits) comprising these devices and/or portals in combination with other therapeutic devices are disclosed.

Abstract: The present invention relates to methods and treatment systems for inactivation of microbes and/or nucleic acids in biological fluids, especially platelet compositions without completely damaging antigens, enzymes and membrane functions. In accordance with the method of the invention, a biological fluid is illuminated with a light source having at least one wavelength within a range of 170 to 2600 nm to inactivate microbes in the composition and inactivate nucleic acids inside cells without destroying proteins (enzymes) and membrane functions.

Abstract: The present media independent communications processing system functions to provide business useful services to customers with the anymedia resources that are required to satisfy the customer's request. In particular, the system carries call information across the entirety of a transaction with the call being managed as an anymedia multi-transactional event. The model used for the present media independent communications processing system, as embodied in a call center, comprises a hallways and rooms paradigm that enables the customer to dynamically navigate their anymedia communications connection to a desired information providing source. As the customer's call is routed during the duration of the communication session, the call context information is stored and used by the rules-based call routing process to identify a source of information/services that is best adapted to serve the needs of this customer.