Patents by Inventor Mark Livingstone
Mark Livingstone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8974813Abstract: A water-swellable linear polymer is made by reacting together a polyethylene oxide of number average molecular weight less than 4,000, an aliphatic diol, and a difunctional diisocyanate. Controlled release composition comprises the polymer together with an active agent. The polymer is able to take up pharmaceutically active agents of molecular weight 200 to 20,000.Type: GrantFiled: June 27, 2007Date of Patent: March 10, 2015Assignee: Ferring B.V.Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Livingstone, Janet Anne Halliday
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Patent number: 8628798Abstract: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.Type: GrantFiled: August 10, 2012Date of Patent: January 14, 2014Assignee: Ferring B.V.Inventors: Janet A. Halliday, Jukka Tuominen, Mark Livingstone, Frank Koppenhagen, Lilias Currie, Sarah Stewart
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Patent number: 8557281Abstract: A pharmaceutical controlled release composition in solid dosage form is provided which comprises (I) a water-swell able linear polymer obtainable by reacting together: (a) a polyethylene oxide; (b) a C5 to C20 diol; and (c) a diisocyanate; and (II) a releasable pharmaceutically active agent.Type: GrantFiled: July 13, 2010Date of Patent: October 15, 2013Assignee: Ferring B.V.Inventors: Janet A. Halliday, Jukka Tuominen, Mark Livingstone, Frank Koppenhagen, Lilias Currie, Sarah Stewart
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Patent number: 8361272Abstract: A linear polymer is obtained by reacting together a polyethylene glycol or polypropylene glycol; a PEG-PPG-PEG or PPG-PEG-PPG block copolymer; a difunctional amine or diol; and a diisocyanate. A controlled release composition comprises the polymer together with an active agent. Active agents of molecular weight 200 to 20,000 may be used.Type: GrantFiled: June 27, 2007Date of Patent: January 29, 2013Assignee: Ferring B.V.Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Livingstone, Janet Anne Halliday
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Patent number: 8361273Abstract: This disclosure relates to a linear polymer obtained by reacting a polyethylene glycol, a polypropylene glycol; a diol; and a diisocyanate, as well as a controlled release composition containing the linear polymer together with an active agent. The active agent can have a molecular weight of 200 g/mol to 20,000 g/mol.Type: GrantFiled: September 6, 2012Date of Patent: January 29, 2013Assignee: Ferring B.V.Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Livingstone, Janet A. Halliday
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Publication number: 20120329883Abstract: This disclosure relates to a linear polymer obtained by reacting a polyethylene glycol, a polypropylene glycol; a diol; and a diisocyanate, as well as a controlled release composition containing the linear polymer together with an active agent. The active agent can have a molecular weight of 200 g/mol to 20,000 g/mol.Type: ApplicationFiled: September 6, 2012Publication date: December 27, 2012Inventors: Jukka Tuominen, AMAIA ZURUTUZA, MARK LIVINGSTONE, JANET ANNE HALLIDAY
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Publication number: 20120302635Abstract: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.Type: ApplicationFiled: August 10, 2012Publication date: November 29, 2012Applicant: Ferring B.V.Inventors: Janet A. Halliday, Jukka Tuominen, Mark Livingstone, Frank Koppenhagen, Lilias Currie, Sarah Stewart
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Publication number: 20110091488Abstract: A pharmaceutical controlled release composition in solid dosage form is provided which comprises (I) a water-swellable linear polymer obtainable by reacting together: (a) a dried polyethylene oxide; (b) a dried C5 to C20 diol; and (c) a Bifunctional diisocyanate; and (II) a releasable pharmaceutically active agent.Type: ApplicationFiled: July 13, 2010Publication date: April 21, 2011Applicant: CONTROLLED THERAPEUTICS (SCOTLAND) LIMITEDInventors: Janet A. HALLIDAY, Jukka TUOMINEN, Mark LIVINGSTONE, Frank KOPPENHAGEN, Lilias CURRIE, Sarah STEWART
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Patent number: 7906297Abstract: The invention discloses two novel phosphorylation sites in human ATR kinase, serine 428 (Ser428) and serine 2317 (Ser2317) respectively, and provides reagents, including antibodies and AQUA peptides, that selectively bind to and/or detect ATR only when phosphorylated at one or more of these respective sites, but do not bind to ATR when not phosphorylated at these respective sites. Also provided are methods for determining the phosphorylation of ATR kinase in a biological sample, by using a detectable reagent that binds to ATR only when phosphorylated at Ser428 and/or Ser2317. Kits comprising the ATR (Ser428, Ser2317)-specific reagents of the invention are also provided.Type: GrantFiled: July 17, 2006Date of Patent: March 15, 2011Assignee: Cell Signaling Technology, Inc.Inventors: Mark Livingstone, Hong Ruan, Robert Polakiewicz
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Publication number: 20090324692Abstract: A linear polymer is obtained by reacting together a polyethylene glycol or polypropylene glycol; a PEG-PPG-PEG or PPG-PEG-PPG block copolymer; a difunctional amine or diol; and a diisocyanate. A controlled release composition comprises the polymer together with an active agent. Active agents of molecular weight 200 to 20,000 may be used.Type: ApplicationFiled: June 27, 2007Publication date: December 31, 2009Applicant: CONTROLLED THERAPEUTICS (SCOTLAND) LIMITEDInventors: Jukka Tuominen, Amaia Zurutuza, Mark Livingstone, Janet A. Halliday
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Publication number: 20070166764Abstract: The invention discloses two novel phosphorylation sites in human ATR kinase, serine 428 (Ser428) and serine 2317 (Ser2317) respectively, and provides reagents, including antibodies and AQUA peptides, that selectively bind to and/or detect ATR only when phosphorylated at one or more of these respective sites, but do not bind to ATR when not phosphorylated at these respective sites. Also provided are methods for determining the phosphorylation of ATR kinase in a biological sample, by using a detectable reagent that binds to ATR only when phosphorylated at Ser428 and/or Ser2317. Kits comprising the ATR (Ser428, Ser2317)-specific reagents of the invention are also provided.Type: ApplicationFiled: July 17, 2006Publication date: July 19, 2007Inventors: Mark Livingstone, Hong Ruan, Robert Polakiewicz
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Patent number: 7195203Abstract: A simplified structure for a wing skin and wing box wherein the internal surface (2) of an aircraft wing skin panel (1) in the wing box includes a multiplicity of strips (3), each strip being associated with a stringer. The strips (3) have different gradients in the span-wise direction S, which is the direction in which the strips extend. The surface of each strip is, in the chord-wise direction C, parallel to the external surface (5). At a junction, at which a rib meets a stringer, the interior surface (2) has an area (4a) that is parallel to the exterior surface (5), such that the rib and stringer at that junction may be simply attached to the wing skin panel (1).Type: GrantFiled: March 25, 2003Date of Patent: March 27, 2007Assignee: Airbus UK LimitedInventors: Mark Livingstone, Darren Crew, Stephen Bell
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Publication number: 20060134161Abstract: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.Type: ApplicationFiled: September 26, 2003Publication date: June 22, 2006Inventors: Janet Halliday, Jukka Tuominen, Mark Livingstone, Frank Koppenhagen, Lilias Currie, Sarah Stewart
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Publication number: 20050268496Abstract: An interchangeable footwear system comprising a shoe assembly including: (a) a base shoe; (b) interchangeable covers, in which any one of a plurality of said covers are adapted to allow fitting to said base shoe forming an assembly so as to change the appearance and use environment of said shoe assembly.Type: ApplicationFiled: March 14, 2003Publication date: December 8, 2005Inventors: Darren Bruce, Mark Livingstone
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Publication number: 20050224652Abstract: The internal surface (2) of an aircraft wing skin panel (1) in the wing box comprises a multiplicity of strips (3), each strip being associated with a stringer. The strips (3) have different gradients in the span-wise direction S, which is the direction in which the strips extend. The surface of each strip is, in the chord-wise direction C, parallel to the external surface (5). At a junction, at which a rib meets a stringer, the interior surface (2) has an area (4a) that is parallel to the exterior surface (5), such that the rib and stringer at that junction may be simply attached to the wing skin panel (1). Manufacture and design of wing skins and wing boxes may be greatly simplified by means of defining the interior surface with such strips.Type: ApplicationFiled: March 25, 2003Publication date: October 13, 2005Inventors: Mark Livingstone, Darren Crew, Stephen Bell