Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

Abstract: The present invention relates to, inter alia, a novel crystalline free-plate habit or morphology, processes for preparing the crystalline free-plate habit, and uses of the crystalline free-plate habit of the L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid (Compound 1) in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in the vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development, and atherosclerosis).

Abstract: This invention in one aspect relates to a mixed-kernel heterojunction transistor, comprising a monolayer film formed of an atomically thin material, and a network of carbon nanotubes (CNTs) vertically stacked over the monolayer film to define an overlap region of the CNT network with the monolayer film, and non-overlap regions of the monolayer film and the CNT network, wherein the overlap region is a mixed-kernel van der Waals heterojunction.

Abstract: Systems and techniques are provided for integrating laboratory generated nuclear magnetic resonance (NMR) data and NMR logging data. An example method can include obtaining NMR logging data describing one or more downhole NMR measurements captured during a drilling operation in a borehole; modifying the NMR logging data to be compatible with a temperature correction algorithm, yielding modified NMR logging data, the temperature correction algorithm having been determined based on laboratory generated NMR data; and applying the temperature correction algorithm to the modified NMR logging data, yielding temperature corrected NMR logging data.

Abstract: A method of quantitating free (unbound) human C5 complement protein (C5) from a sample comprising: binding biotinylated anti-C5 capture antibody to strepavidin-coated particles; capturing the free (unbound) C5 in the sample; detecting the captured free C5; and quantitating the captured free C5 using laser-induced fluorescence detection; wherein the method is performed in a Gyros Bioaffy 200 CD in a Gyrolab xPlore or a Gyrolab XP instrument.

Abstract: A negative electrode composition includes a silicon containing material and a crosslinked polymer containing coating surrounding at least a portion of the silicon containing material. The crosslinked polymer containing coating comprises a (co)polymer derived from polymerization of one or more vinylic monomers comprising a carboxyl or carboxylate group.

Abstract: Systems, apparatuses, and methods for cost evaluation and motion planning for robotic devices are disclosed herein. According to at least one non-limiting exemplary embodiment, a method for producing and evaluating a continuous and differentiable total cost as a function of all available motion commands is disclosed and may be utilized in conjunction with a gradient descent to determine a minimum cost motion command corresponding to an optimal motion for a robotic device to execute in accordance with a target trajectory and obstacle avoidance.

Abstract: A production logging tool has a housing, a flowmeter assembly, a heating element, a drive, a clutch, and a controller. The housing has a first end attached to a wellbore string. The flowmeter assembly has a spinner exposed to fluid in the production string and a spinner shaft fixed to the spinner and extending from a rear surface of the spinner into the housing. The spinner shaft is rotatably attached to the housing. The heating element is attached to the spinner. The drive is disposed within the housing. The controller is operationally coupled to the drive and the heating element. The controller activates and deactivates at least one of the drive or the heating element to heat a volume around the spinner with the heating element or selectively spin the spinner with the drive.

Abstract: A method of cleaning a well includes flowing well fluid within the well while running a cleaning tool into the well, injecting the well fluid with a fluid thickening agent through multiple nozzles of the well cleaning tool to form thickened well fluid, dislodging metallic debris and non-metallic debris accumulated along a wall of the well with multiple brushes of the cleaning tool, carrying the non-metallic debris out of the well with the thickened well fluid, and capturing the metallic debris at a capture device of the cleaning tool.

Abstract: A determination of a continuous oil density log for a hydrocarbon reservoir accessible via a well drilling into the formation having the reservoir. The logging operations may be conducted in the well to generate a carbon-oxygen ratio (C/O) log, a water saturation log, and a porosity log. A continuous oil density log may be determined using the C/O log, the water saturation log, the porosity log, and carbon and oxygen density values. The continuous oil density log may be used in further characterization and development of the hydrocarbon reservoir.

Abstract: Systems and methods for detecting a formation fluid kick in a wellbore include drilling into a subsurface formation using a drill string including a pup joint. Measuring properties of a drilling fluid inside of the drill string at the pup joint using a first sensor module and measuring properties of the drilling fluid outside of the drill string at the pup joint using a second sensor module. Analyzing the measured properties of the drilling fluid inside and outside of the drill string at the pup joint including calculating a difference between the properties of the drilling fluid inside and outside of the drill string at the pup joint. Determining an occurrence of the kick based on the difference between the properties of the drilling fluid inside and outside of the drill string at the pup joint exceeding a pre-determined threshold value.

Abstract: Optical gain media and gain devices are required for lasing devices and high intensity optical systems across a wide range of application. A compact optical gain device that provides near-infrared and infrared lasing at room temperature includes an optical microcavity having a refractive index and a curvilinear outer surface with an angle of curvature such that the optical microcavity supports the propagation of an electromagnetic whispering gallery mode. A plurality of optical gain structures are disposed along the curvilinear outer surface of the optical microcavity, the each of the optical gain structures having an optically active wavelength range over which each of the corresponding optical gain structures provides optical gain to radiation through stimulated emission.

Abstract: Methods and systems are provided that perform sonic measurements in a high-angle wellbore or horizontal wellbore or vertical wellbore penetrating highly dipped formation layers where the formation layers can have a high degree of dip relative to the wellbore. Sonic data can be generated from the sonic measurements and processed using multiple arrival event processing to determine formation porosity, elastic rock properties and geometric information for a tool layer and nearby shoulder bed. Such information can be integrated into a 2D or 3D layered model of the formation. The elastic rock properties of the tool layer and shoulder bed derived from the multiple arrival event processing can provide more representative elastic property values, which can account for heterogeneity along the wellbore.

Abstract: Secure user authentication using a OTP involve pre-storing an application on a first device for generating a valid OTP for the user responsive to receiving entry of a valid PIN, no part of the valid PIN is stored on the first device and pre-storing on a back-end server the valid PIN and a valid shared secret for the user. Upon receiving entry of a purported PIN, a purported shared secret is dynamically synthesized on the first device by the application based on the purported PIN and a purported OTP is generated on the first device. When entry of the purported OTP is received by the server in an attempt to log on the server from a second device, the server cryptographically calculates a window of OTPs, and logs on to the server from the second device is allowed if the calculated window of OTPs corresponds to the received OTP.

Abstract: Provided herein are antibodies which bind to ceruloplasmin and are useful for various applications, including detecting ceruloplasmin and immunocapturing ceruloplasmin in biological samples. The antibodies are useful in methods of measuring non-ceruloplasmin-bound copper concentrations and labile-bound copper concentrations in biological samples.

Abstract: This disclosure relates to methods of diagnosing and treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD).

Abstract: A hydrocarbon well downhole fluid acquisition and injection system for selecting and stimulating zones based on operations of the system. Target depths in a hydrocarbon well are identified, and reservoir fluids may be acquired or tagging agents may be injected at the target depths using a specialized hydrocarbon well downhole fluid acquisition and injection system. The well may be operated to generate flow of fluids, and the reservoir fluids may be monitored and assessed for the presence of tagging agents. The presence of tagging agents and the fluid sample may be assessed to identify zones that may be candidates for stimulation or other operations.

Abstract: A production logging tool has a housing, a flowmeter assembly, a heating element, a drive, a clutch, and a controller. The housing has a first end attached to a wellbore string. The flowmeter assembly has a spinner exposed to fluid in the production string and a spinner shaft fixed to the spinner and extending from a rear surface of the spinner into the housing. The spinner shaft is rotatably attached to the housing. The heating element is attached to the spinner. The drive is disposed within the housing. The controller is operationally coupled to the drive and the heating element. The controller activates and deactivates at least one of the drive or the heating element to heat a volume around the spinner with the heating element or selectively spin the spinner with the drive.

Abstract: A method of quantitating free (unbound) human C5a complement protein (C5a) from a sample comprising: binding biotinylated anti-C5a capture antibody to strepavidin-coated particles; capturing the free (unbound) C5 in the sample; detecting the captured free C5a; and quantitating the captured free C5 using laser-induced fluorescence detection; wherein the method is performed in a Gyros Bioaffy 200 CD in a Gyrolab xPlore or a Gyrolab XP instrument; wherein human C5 is first removed from the sample.

Abstract: A single stage high pressure mercury injection capillary pressure measurement apparatus includes a sample sub-assembly, a transducer sub-assembly, a hydraulic intensifier, and a gas cylinder. The sample sub-assembly includes a casing having walls defining an interior volume, a penetrometer arranged in the casing, the penetrometer having walls defining a sample volume, an annular space defined between the walls of the casing and the walls of the penetrometer, and a common chamber fluidly connected to the annular space by a fluid line and to the sample volume of the penetrometer by a tubing. The transducer sub-assembly is fluidly connected to the sample sub-assembly via the common chamber and includes a plurality of high-pressure transducers a plurality of low-pressure transducers. The hydraulic intensifier is fluidly connected to the common chamber and is configured to apply a high pressure to the annular space.