Abstract: Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein Ring A, Ring B, Ring C, R1, R2, R3, R4, R5, L, m, n, and p are as defined herein. The compounds are modulators of G-protein coupled receptor 88 (GPR88). Also disclosed are pharmaceutical compositions comprising the compounds; and the compounds for use in the treatment of diseases mediated by GPR88, including Tourette's Syndrome, Huntington's Disease (HD), Addiction, Parkinson's Disease (PD), Schizophrenia, Alzheimer's disease, and Attention Deficit Hyperactivity Disorder (ADHD).

Abstract: A nebuliser comprises an outlet aperture and a liquid capillary. A method of operating the nebuliser comprises supplying a gas to the outlet aperture, measuring a flow rate of the gas supplied to the outlet aperture, and determining a position of the liquid capillary relative to the outlet aperture based on the measured flow rate.

Abstract: Provided herein are compounds that form covalent bonds with peptidases, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SPase), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Abstract: A field configurable support housing assembly 10 is provided. The support housing assembly comprises a support housing base 20 and a cylindrical hollow fuel rocket 40. The support housing base 20 includes at least one through hole. The cylindrical hollow fuel rocket 40 includes a nozzle tip 50 positioned such that the hollow fuel rocket 40 generally aligns with the through hole. The fuel rocket 40 is reconfigurable on-site using a mechanical attachment 100. A method for rapid on-site reconfiguration of a cylindrical hollow fuel rocket 40 is also provided.

Abstract: A drawer locking device for a drawer including at least one side wall, the drawer slidingly closable within a cabinet frame, the drawer locking device including: a mounting portion including three walls defining a U-shaped slot including an inner wall, an outer wall, and a top wall forming a space between the inner wall and outer wall; and a latching portion pivotally coupled to the inner wall, the latching portion including a rear ramp surface, a front surface, and a release lever, wherein, when the drawer safety latch is installed on the drawer side wall such that the drawer side wall is positioned within the space between the inner wall and outer wall, the rear ramp faces the rear of the drawer and the front surface faces the front of the drawer, wherein the latching portion is defeatably biased towards a lock position.

Abstract: Systems and methods for creating universal microcode images and for reconstructing a microcode image from a universal microcode image are described in the present disclosure. One method, among others, comprises receiving a plurality of microcode images each configured to initialize hardware within an electronic device before the electronic device is booted up. The method also includes separating each microcode image into sections and comparing the sections to determine whether or not two or more sections contain identical code. The method also includes creating a universal microcode image from the sections that are unique.

Abstract: A drawer locking device for a drawer including at least one side wall, the drawer slidingly closable within a cabinet frame, the drawer locking device including: a mounting portion including three walls defining a U-shaped slot including an inner wall, an outer wall, and a top wall forming a space between the inner wall and outer wall; and a latching portion pivotally coupled to the inner wall, the latching portion including a rear ramp surface, a front surface, and a release lever, wherein, when the drawer safety latch is installed on the drawer side wall such that the drawer side wall is positioned within the space between the inner wall and outer wall, the rear ramp faces the rear of the drawer and the front surface faces the front of the drawer, wherein the latching portion is defeatably biased towards a lock position.

Abstract: A sealing apparatus for a downhole tool having a movable member (11) which moves relative to a housing, the sealing apparatus comprising: at least one sealing member having (10A) a first position in which the sealing member is spaced from the movable member and a second position in which the sealing member (10B) is in contact with the movable member (IB) to provide a sealing barrier; and switching means for switching the sealing member between the first and second positions.

Abstract: Embodiments include a fiducial deployment system including a needle and at least two adjacent and releasably-engaged fiducials retained within a lumen of the needle by engagement with each other and/or by engagement with a pusher element. A fiducial may include one or more mechanical engagement structures that interengage with and/or are rupturably attached to one or more adjacent fiducials. The needle, which may include echogenic enhancements, may be configured to deliver a plurality of fiducials to a target location in serial fashion, one at a time. A variety of releasably-engaged fiducials are disclosed, as are methods for use.

Abstract: Systems and methods for creating universal microcode images and for reconstructing a microcode image from a universal microcode image are described in the present disclosure. One method, among others, comprises receiving a plurality of microcode images each configured to initialize hardware within an electronic device before the electronic device is booted up. The method also includes separating each microcode image into sections and comparing the sections to determine whether or not two or more sections contain identical code. The method also includes creating a universal microcode image from the sections that are unique.

Abstract: Systems and methods for creating universal microcode images and for reconstructing a microcode image from a universal microcode image are described in the present disclosure. One method, among others, comprises receiving a plurality of microcode images each configured to initialize hardware within an electronic device before the electronic device is booted up. The method also includes separating each microcode image into sections and comparing the sections to determine whether or not two or more sections contain identical code. The method also includes creating a universal microcode image from the sections that are unique.

Abstract: The present invention relates methods and apparatus for lining a wellbore. In one aspect, a drilling assembly having an earth removal member and a wellbore lining conduit is manipulated to advance into the earth. The drilling assembly includes a first fluid flow path and a second fluid flow path. Fluid is flowed through the first fluid flow path, and at least a portion of which may return through the second fluid flow path. In one embodiment, the drilling assembly is provided with a third fluid flow path. After drilling has been completed, wellbore lining conduit may be cemented in the wellbore.

Abstract: A chute for inspection and sorting apparatus is disclosed. It comprises two sections; a first, upper section (6) and a lower, grooved section (2). The first section has a smooth, normally polished surface which allows product pieces thereon to move laterally as well as downwards. In the lower section (2) product pieces are restricted in their lateral movement by the grooves (12) and move into alignment with the grooves before being discharged into the inspection zone (22) of the apparatus. If the apparatus is for inspection only, then the product pieces continue to a collection receptacle. If the apparatus is for sorting, then an ejector (26) is included which acts in response to signals from the inspection station to eject selected pieces from the product stream. Those are deflected into a reject receptacle (28) while the remainder proceed into the collection receptacle (24).

Abstract: The present invention relates methods and apparatus for lining a wellbore. In one aspect, a drilling assembly having an earth removal member and a wellbore lining conduit is manipulated to advance into the earth. The drilling assembly includes a first fluid flow path and a second fluid flow path. Fluid is flowed through the first fluid flow path, and at least a portion of which may return through the second fluid flow path. In one embodiment, the drilling assembly is provided with a third fluid flow path. After drilling has been completed, wellbore lining conduit may be cemented in the wellbore.

Abstract: An automobile storage system is disclosed. The system includes a base, a pair of opposed side walls, and an end wall. The system further includes an adjustable divider tray with a first segment and a second segment. The first segment is pivotally connected to the end wall or one of the side walls along a first hinge axis, and the first segment is pivotally connected to the second segment along a second hinge axis. The hinge axes are parallel. The tray has a closed position in which the tray divides the interior into a first compartment and a second compartment, the first compartment is accessible, and the divider tray is disposed between the access opening and the second compartment. The tray is movable away from the closed position to an open position in which the interior of the system functions as a unitary compartment.

Abstract: A sealing apparatus for a downhole tool having a movable member (11) which moves relative to a housing, the sealing apparatus comprising: at least one sealing member having (10A) a first position in which the sealing member is spaced from the movable member and a second position in which the sealing member (10B) is in contact with the movable member (IB) to provide a sealing barrier; and switching means for switching the sealing member between the first and second positions.

Abstract: A low fluid sensor for an internal combustion engine. The sensor includes a base with helically threaded post and a float slidably mounted on the post. The float rotates about the post as it moves longitudinally along it. In the preferred embodiment, eccentric mounting of the assembly along with its lobe shape act in concert with the pitch of the screw threads and fluid viscosity to dampen the buoyant movement of the float against fluid turbulence. At a predetermined level a latch spring on the float contacts an ignition circuit terminal and grounds the engine ignition circuit. A catch holds the float at the pre-determined level, preventing engine starting, so that the sensor may only be reset by addition of fluid and re-insertion of the dipstick.

Abstract: Methods and apparatus are provided to place a conductor pipe and a casing in a subsea environment. In one embodiment, a conductor pipe is jetted or drilled into the subsea floor. Thereafter, a casing drilling assembly comprising a drill casing and a drilling assembly is connected to the drill pipe using a crossover. The drilling assembly urged into the seafloor until a casing latch on the drilling assembly is engaged with a casing profile of the conductor pipe. During drilling, instrumentation in the drilling assembly may be used to measure geophysical data. The measured data may be used to optimize the drilling process. After the drill casing is engaged with the conductor pipe, cementing may be performed to set the drill casing.

Abstract: Disclosed are systems and methods for reserve allocation of event data. A request event is received. The request event is associated with memory storing request event data. Memory for response event data is allocated from a first pool. The response event data is associated with a response, and the response is associated with the request. Upon failure of the allocation of memory for the response event data, memory is obtained for out-of-memory response event data. The out-of-memory response event data is associated with the response event. The request event is completed using the response event.

Abstract: A low fluid sensor for an internal combustion engine. The sensor includes a base with helically threaded post and a float slidably mounted on the post. The float rotates about the post as it moves longitudinally along it. In the preferred embodiment, eccentric mounting of the assembly along with its lobe shape act in concert with the pitch of the screw threads and fluid viscosity to dampen the buoyant movement of the float against fluid turbulence. At a predetermined level a latch spring on the float contacts an ignition circuit terminal and grounds the engine ignition circuit. A catch holds the float at the pre-determined level, preventing engine starting, so that the sensor may only be reset by addition of fluid and re-insertion of the dipstick.