Patents by Inventor Mark N. Gillespie

Mark N. Gillespie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of disease conditions via administration of DNA repair enzyme
    Patent number: 9404102
    Abstract: The present invention is directed to compositions and methods of preserving viability of islets of Langerhans for transplantation, and treating various disease and other abnormal or pathological conditions, including inflammatory bowel disease, ischemic heart disease, acute lung injury, acute respiratory distress syndrome and radiation-induced brain injury, with DNA repair enzymes that are directed to the mitochondria.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: August 2, 2016
    Assignee: University of South Alabama
    Inventors: Glenn Wilson, Susan Ledoux, Mikhail Alexeyev, Inna Shokolenko, Mark N. Gillespie
  • TREATMENT OF DISEASE CONDITIONS VIA ADMINISTRATION OF DNA REPAIR ENZYME
    Publication number: 20150118217
    Abstract: The present invention is directed to compositions and methods of preserving viability of islets of Langerhans for transplantation, and treating various disease and other abnormal or pathological conditions, including inflammatory bowel disease, ischemic heart disease, acute lung injury, acute respiratory distress syndrome and radiation-induced brain injury, with DNA repair enzymes that are directed to the mitochondria.
    Type: Application
    Filed: October 20, 2014
    Publication date: April 30, 2015
    Inventors: Glenn Wilson, Susan Ledoux, Mikhail Alexeyev, Inna Shokolenko, Mark N. Gillespie
  • Treatment of disease conditions via administration of DNA repair enzyme
    Patent number: 8865160
    Abstract: The present invention is directed to compositions and methods of preserving viability of islets of Langerhans for transplantation, and treating various diseases and other abnormal or pathological conditions, including inflammatory bowel disease, ischemic heart disease, acute lung injury, acute respiratory distress syndrome and radiation-induced brain injury, with DNA repair enzymes that are directed to the mitochondria.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: October 21, 2014
    Assignee: University of South Alabama
    Inventors: Glenn Wilson, Susan Ledoux, Mikhail Alexeyev, Inna Shokolenko, Mark N. Gillespie
  • TREATMENT OF DISEASE CONDITIONS VIA ADMINISTRATION OF DNA REPAIR ENZYME
    Publication number: 20110110908
    Abstract: The present invention is directed to compositions and methods of preserving viability of islets of Langerhans for transplantation, and treating various diseases and other abnormal or pathological conditions, including inflammatory bowel disease, ischemic heart disease, acute lung injury, acute respiratory distress syndrome and radiation-induced brain injury, with DNA repair enzymes that are directed to the mitochondria.
    Type: Application
    Filed: February 9, 2009
    Publication date: May 12, 2011
    Applicant: UNIVERSITY OF SOUTH ALABAMA
    Inventors: Glenn Wilson, Susan Ledoux, Mikhail Alexeyev, Inna Shokolenko, Mark N. Gillespie
  • Polyamine-polyamine and polyamine-protein transport inhibitor conjugates and their use as pharmaceuticals and in research relating to polyamine transport
    Patent number: 5456908
    Abstract: Novel classes of inhibitors which selectively inhibit the cellular transport of normally transported substances, specifically polyamines are taught which comprise (i) polymers of the transported substance or (ii) protein or polypeptide conjugates of the transported substance. These inhibitors may be used in vitro to assess the effect of the transported substance on cellular functions and in vivo for treating disease conditions involving transport of the particular substance, e.g., a polyamine.
    Type: Grant
    Filed: March 1, 1994
    Date of Patent: October 10, 1995
    Assignee: The University of Kentucky Research Foundation
    Inventors: Shewan M. Aziz, Mark N. Gillespie