Abstract: A bridge plug includes a mandrel, a setting cone disposed at least partially about the mandrel, a slip ring and a sealing element disposed at least partially about the setting cone, and a guide shoe operatively coupled to a downhole end of the mandrel. The bridge plug is actuatable from a run-in state to a deployed state, wherein, when the bridge plug is in the deployed state, the mandrel is axially movable relative to the setting cone to seal or open a flow path through the bridge plug.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Apparatuses, systems, and methods for a damper for a printed circuit board assembly (PCBA). One example apparatus can include a PCBA of a solid state drive (SSD) and a damper configured to contact the PCBA, contact an enclosure of the SSD, and damp shock impulses applied to the SSD.

Abstract: An external controller assembly for a medical device implanted in a patient includes an external controller and an external driveline assembly. The external controller includes an external controller display viewable by the patient. The external driveline assembly includes an external driveline cable and an external driveline distal connector. The external driveline cable is connected to the external driveline distal connector and the external controller. The external driveline cable accommodates positioning of the external driveline distal connector, by the patient, for simultaneous viewing of the external driveline distal connector and the external controller display by the patient. The external driveline distal connector is adapted to be connected to the distal driveline proximal connector by the patient. The external driveline distal connector is adapted to be disconnected from the distal driveline proximal connector by the patient.

Abstract: An elevator of a medical device may comprise: a plurality of segments joined together by at least one hinge, and a control element coupled to at least one segment of the plurality of segments. A first segment of the plurality of segments may be a discrete structure. Proximal or distal movement of the control element may be configured to move the at least one segment of the plurality of segments relative to another of the plurality of segments.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: A turf maintenance apparatus having folding handles facilitating compact storage is presented herein. The folding handles can be compressed or extended to adjust overall length and can rotate between an extended operator position and a folded storage position. Depending on implementation, the folding handles can be locked in the folded storage position and can also lock in the extended operator position. An operator presence device(s) can disable operation of a motor or engine when the handles are not locked in the extended operator position.

Abstract: An air channel is utilized to ventilate a door lock for the purpose of reducing the condensation of warm, humid, air within the lock. The air channel is configured to be located between a surface mounted door lock and the door panel and vent the space between the interior and exterior locks, including the door bore. In some embodiments, the air channel is formed into the mounting bracket for the interior door lock. The air channel may be implemented to reduce condensation without requiring seals or gaskets between the interior and exterior locks.

Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible core wire having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the core wire distal portion. A conduit extends along at least a portion of the core wire. The conduit has a lumen configured to pass an embolic element therethrough.

Abstract: A method of displaying compass headings includes the steps of: assigning specific colors to at least the four primary directional points North, East, South and West of a compass; and emitting the assigned colors from a single light source (e.g., a tri-colored LED) to visually indicate a current compass heading or orientation of a person, object, vehicle or craft (e.g., boat, airplane, helicopter or drone). The method may further include use of coded flashes of one or more colors to indicate compass points while minimizing the number of assigned colors for ease of memorization.

Abstract: A method of displaying compass headings includes the steps of: assigning specific colors to at least the four primary directional points North, East, South and West of a compass; and emitting the assigned colors from a single light source (e.g., a tri-colored LED) to visually indicate a current compass heading or orientation of a person, object, vehicle or craft (e.g., boat, airplane, helicopter or drone). The method may further include use of coded flashes of one or more colors to indicate compass points while minimizing the number of assigned colors for ease of memorization.

Abstract: Systems and methods are disclosed for programming non-volatile storage. Methods involve identifying boot loader code stored in a first partition of a non-volatile storage, the boot loader code being marked as active, executing the boot loader code using one or more processors of the computing system, loading a firmware image to a second partition of the non-volatile storage, the second partition being separate from the first partition, and marking the firmware image as active. Methods further involve detecting a power loss event and, following a power cycle, determining that the firmware image is stored in the second partition and has been marked as active, and, in response to said determination, making a copy of the firmware image and storing the copy in the first partition.

Abstract: A device may comprise data storage, a power manager and a bridge device that is coupled to the data storage and to the power manager, and configured to bridge between at least a first data protocol and at least a second data protocol. The bridge device may comprise a UART, a first clock, a second clock and bridge device firmware configured to cause the bridge device to selectively configure the UART for communication using the first clock or the second clock. The power manager may be configured to, when a command is to be issued to the data storage when the bridge device firmware has configured the UART for communication using the first clock, assert a signal that causes the bridge device firmware to stop configuring the UART for communication using the first clock and to configure the UART for communication using the second clock.

Abstract: A device may comprise data storage, a power manager and a bridge device that is coupled to the data storage and to the power manager, and configured to bridge between at least a first data protocol and at least a second data protocol. The bridge device may comprise a UART, a first clock, a second clock and bridge device firmware configured to cause the bridge device to selectively configure the UART for communication using the first clock or the second clock. The power manager may be configured to, when a command is to be issued to the data storage when the bridge device firmware has configured the UART for communication using the first clock, assert a signal that causes the bridge device firmware to stop configuring the UART for communication using the first clock and to configure the UART for communication using the second clock.

Abstract: A computer system for real-time generation of location establishment severity profile alert based on aggregated quality-data corresponding to a plurality of location establishments is provided herein. A computer system provides for the electronic intake, and aggregate analysis of quality-data for establishment locations. Quality-data is accessed from one or more sources, and corresponds to multiple establishment locations. The system stores quality-data events identifying received quality-data, with a stored representation of a quality-data event's severity level. The system aggregates the stored quality-data events for example by calculating aggregate severity values associated with groups of establishment locations. In some embodiments, quality-data and/or aggregate severity values are normalized according to one or more factors, such as historic geographic data.

Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.

Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.

Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.

Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.