Patents by Inventor Mark Robert Bray

Mark Robert Bray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LILRB1 AND LILRB2-BINDING MOLECULES AND USES THEREFOR
    Publication number: 20240150462
    Abstract: The invention provides novel anti-LILR antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer, autoimmune disease, or allergic inflammation.
    Type: Application
    Filed: March 11, 2022
    Publication date: May 9, 2024
    Inventors: Richard BROKX, Jacqueline M. MASON, Mark Robert BRAY, Gordon S. DUNCAN
  • COMBINATION THERAPIES FOR INHIBITION OF TTK PROTEIN KINASE
    Publication number: 20230390294
    Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
    Type: Application
    Filed: August 18, 2023
    Publication date: December 7, 2023
    Inventors: Mark Robert Bray, Jacqueline M. Mason, Tak Wah Mak, Graham Fletcher
  • Combination therapies for inhibition of TTK protein kinase
    Patent number: 11766437
    Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: September 26, 2023
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Mark Robert Bray, Jacqueline M. Mason, Tak W. Mak, Graham Fletcher
  • CRYSTAL FORM S4 OF THE PLK4 INHIBITOR (1R,2S)-(E)-2-(3-(4-((CIS-2,6-DIMETHYLMORPHOLINO)METHYL)STYRYL)- 1 H-IMIDAZOL-6- YL)-5'-METHOXYSPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONE FUMARATE
    Publication number: 20220204494
    Abstract: Disclosed is Crystal Form S4 of a fumarate salt of compound (I) represented by the following structural formula: (I) The molar ratio between compound (I) and fumaric acid is 1.0:1:0. Crystal Form S4, 5 characterized by an X-ray powder diffraction pattern which comprises peaks at 6.6°, 9.8°, 16.3°, 21.1°, 28.7°, and 30.2°±0.2 in 2?.
    Type: Application
    Filed: April 23, 2020
    Publication date: June 30, 2022
    Inventors: Sze-Wan Li, Mark Robert Bray
  • COMBINATION THERAPIES FOR INHIBITION OF TTK PROTEIN KINASE
    Publication number: 20200230144
    Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
    Type: Application
    Filed: August 1, 2018
    Publication date: July 23, 2020
    Inventors: Mark Robert Bray, Jacqueline M. Mason, Tak W. Mak, Graham Fletcher
  • Cytotoxic heteromeric protein combinatorial libraries
    Patent number: 7713915
    Abstract: A method is provided for constructing, identifying and using new therapeutic or diagnostic proteins capable of binding to a target cell. The new proteins are derived by mutating a binding subunit of a wild type heteromeric cytotoxic protein to create a library of microorganism clones producing mutant proteins which are then screened for their ability to specifically bind to and kill a target cell.
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: May 11, 2010
    Assignee: Molecular Templates, Inc.
    Inventors: Jean Gariepy, Mark Robert Bray