Patents by Inventor Mark Rolfe

Mark Rolfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230172936
    Abstract: Described herein are methods of treating cancer in a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising 1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide, or a pharmaceutically acceptable salt thereof, whereby the subject experiences a therapeutic response.
    Type: Application
    Filed: May 10, 2021
    Publication date: June 8, 2023
    Inventors: Monic Jain STUART, Ronan LE MOIGNE, Daniel James ANDERSON, Mark ROLFE, Kanya Lakshmi RAJANGAM, Stevan Nicholas DJAKOVIC, Jesse Daniel VARGAS
  • Patent number: 10569967
    Abstract: Integrated software systems and methods that can control the design, emulation, testing and production activities of a conveyor based system. In embodiments, the control system implements an object-oriented like environment into a PLC (Programmable Logic Controller) system and uses its software to define and control the operation of the PLC dynamically from a computer. In other embodiments, a hot backup method allows the conveyor system to continue to function on failure of one or more PLCs.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: February 25, 2020
    Inventor: Mark Rolfes
  • Publication number: 20180162652
    Abstract: Integrated software systems and methods that can control the design, emulation, testing and production activities of a conveyor based system. In embodiments, the control system implements an object-oriented like environment into a PLC (Programmable Logic Controller) system and uses its software to define and control the operation of the PLC dynamically from a computer. In other embodiments, a hot backup method allows the conveyor system to continue to function on failure of one or more PLCs.
    Type: Application
    Filed: December 13, 2017
    Publication date: June 14, 2018
    Inventor: Mark Rolfes
  • Patent number: 7566455
    Abstract: The present invention relates to the discovery in eukaryotic cells, particularly human cells, of novel protein-protein interactions between certain cellular proteins, referred to herein as “E6AP-binding proteins” or “E6AP-BPs”, and the cellular protein E6AP, the latter of which is a component of a ubiquitin-ligase (E3) enzyme. The association of E6AP and the subject E6AP-binding proteins implicates the E6AP-binding proteins in a number of basic cellular functions, such as regulation of gene expression, regulation of the cell-cycle, modification of cell surface receptors, biogenesis of ribosomes, and DNA repair. One of the E6AP-binding proteins shares certain homology with the papillomavirus E6 protein, which also binds E6AP.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 28, 2009
    Assignee: GPC Biotech, Inc.
    Inventors: Peggy L. Beer-Romero, Giulio Draetta, Mark Rolfe
  • Patent number: 7404500
    Abstract: A pill dispensing cap for a bottle has an inner sleeve with a divider panel and a first base panel rotatable within an outer sleeve having a second base panel. First and second window openings are defined in the first and second base panels. A plate moveable across and within the two sleeves defines a third window opening and a fourth window opening is defined in the divider panel. The plate can be held in an initial position wherein the first and second windows are aligned, whilst the third and fourth windows are not aligned. The outer sleeve is rotatable to a condition wherein the first and second windows are not aligned and the plate can then be slid across to a condition wherein the third and fourth windows are aligned to allow pills in a bottle to enter the inner sleeve.
    Type: Grant
    Filed: May 13, 2004
    Date of Patent: July 29, 2008
    Assignee: Owen Mumford Limited
    Inventors: Dennis Marteau, Steven Mark Rolfe
  • Publication number: 20060207996
    Abstract: A pill dispensing cap for a bottle has an inner sleeve with a divider panel and a first base panel rotatable within an outer sleeve having a second base panel. First and second window openings are defined in the first and second base panels. A plate moveable across and within the two sleeves defines a third window opening and a fourth window opening is defined in the divider panel. The plate can be held in an initial position wherein the first and second windows are aligned, whilst the third and fourth windows are not aligned. The outer sleeve is rotatable to a condition wherein the first and second windows are not aligned and the plate can then be slid across to a condition wherein the third and fourth windows are aligned to allow pills in a bottle to enter the inner sleeve.
    Type: Application
    Filed: May 13, 2004
    Publication date: September 21, 2006
    Applicant: OWEN MUMFORD LIMITED
    Inventors: Dennis Marteau, Steven Mark Rolfe
  • Patent number: 6747128
    Abstract: The present invention relates to the isolation of a new class of ubiquitin ligases involved in protein degradation in vertebrate organisms, such as protein degradation of cell cycle regulatory proteins. Accordingly, the invention provides nucleic acids and the proteins encoded by said nucleic acids which play a role in the ubiquitinylation and subsequent degradation of substrate proteins and in regulating cell proliferation, cell differentiation, and cell survival.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: June 8, 2004
    Assignee: GPC Biotech, Inc.
    Inventors: Maureen Caligiuri, Mark Rolfe
  • Publication number: 20020025569
    Abstract: The present invention relates to the isolation of a new class of ubiquitin ligases involved in protein degradation in vertebrate organisms, such as protein degradation of cell cycle regulatory proteins. Accordingly, the invention provides nucleic acids and the proteins encoded by said nucleic acids which play a role in the ubiquitinylation and subsequent degradation of substrate proteins and in regulating cell proliferation, cell differentiation, and cell survival.
    Type: Application
    Filed: August 20, 1997
    Publication date: February 28, 2002
    Inventors: MAUREEN CALIGIURI, MARK ROLFE
  • Patent number: 6068982
    Abstract: The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein, such as p53, p27, myc, fos, MAT.alpha.2, or cyclins. The invention further relates to novel ubiquitin-conjugating enzymes, and uses related thereto.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: May 30, 2000
    Assignee: Mitotix, Inc.
    Inventors: Mark Rolfe, Maria Isabel Chiu, Guillaume Cottarel, Vivian Berlin, Veronique Damagnez, Giulio Draetta
  • Patent number: 6060262
    Abstract: The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of I.kappa.B and other I.kappa.B-related polypeptides.
    Type: Grant
    Filed: July 16, 1997
    Date of Patent: May 9, 2000
    Assignee: Mitotix, Inc.
    Inventors: Peggy Beer-Romero, Peter J. Strack, Susan J. Glass, Mark Rolfe
  • Patent number: 5981699
    Abstract: The present invention concerns a novel human ubiquitin-conjugating enzyme which is implicated in the ubiquitin-mediated inactivation of cell-cycle regulatory proteins, partucularly p53. The present invention makes available diagnostic and therapeutic assays and reagents for detecting and treating transformed cells, such as may be useful in the detection of cancer. The present invention also provides reagents for altering the normal regulation cell proliferation in untransformed cells, such as by upregulating certain cell-cycle checkpoints, e.g. to protect normal cells against DNA damaging reagents.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: November 9, 1999
    Assignee: Mitotix, Inc.
    Inventors: Giulio Draetta, Mark Rolfe, Jens W. Eckstein
  • Patent number: 5968761
    Abstract: The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein, such as p53, p27, myc, fos, MAT.alpha.2, or cyclins. The invention further relates to novel ubiquitin-conjugating enzymes, and uses related thereto.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 19, 1999
    Assignee: Mitotix, Inc.
    Inventors: Mark Rolfe, Maria Isabel Chiu, Guillaume Cottarel, Vivian Berlin, Veronique Damagnez, Giulio Draetta
  • Patent number: 5858987
    Abstract: The present invention relates to the discovery that antisense nucleic acids complimentary to an E6AP gene can be used to regulate cellular p53 levels. In general the invention features E6AP antisense constructs which, by inhibiting E6AP activity, can modulate cellular p53 levels in both p53+ transformed cells and in normal cells. The invention also provides methods for treating papillomavirus (PV) induced condition, methods for regulating cellular p53 levels and methods for regulating cellular proliferation.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: January 12, 1999
    Assignee: Mitotix, Inc.
    Inventors: Peggy L. Beer-Romero, Giulio Draetta, Mark Rolfe
  • Patent number: 5744343
    Abstract: The present invention concerns three ubiquitin-conjugating enzymes.
    Type: Grant
    Filed: September 13, 1994
    Date of Patent: April 28, 1998
    Assignee: Mitotix, Inc.
    Inventors: Giulio Draetta, Mark Rolfe, Jens W. Eckstein, Guillaume Cottarel
  • Patent number: D444087
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: June 26, 2001
    Assignee: Ecowater Systems, Inc.
    Inventors: Jim Johannsen, David Bardwell, Mark Rolfes
  • Patent number: D434827
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: December 5, 2000
    Assignee: Ecowater Systems, Inc.
    Inventors: Jeff Zimmerman, Mike Drager, Mike Hanson, Paul Myhre, Mark Rolfes