Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: A GPU filters graphics workloads to identify candidates for profiling. In response to receiving a graphics workload for the first time, the GPU determines if the graphics workload would require the GPU shaders to use fewer resources than would be spent profiling and determining a resource allocation for subsequent receipts of the same or a similar graphics workload. The GPU can further determine if the shaders are processing more than one graphics workload at the same time, such that the performance characteristics of each individual graphics workload cannot be effectively isolated. The GPU then profiles and stores resource allocations for a plurality of shaders for processing the filtered graphics workloads, and applies those stored resource allocations when the same or a similar graphics workload is received subsequently by the GPU.

Abstract: A GPU filters graphics workloads to identify candidates for profiling. In response to receiving a graphics workload for the first time, the GPU determines if the graphics workload would require the GPU shaders to use fewer resources than would be spent profiling and determining a resource allocation for subsequent receipts of the same or a similar graphics workload. The GPU can further determine if the shaders are processing more than one graphics workload at the same time, such that the performance characteristics of each individual graphics workload cannot be effectively isolated. The GPU then profiles and stores resource allocations for a plurality of shaders for processing the filtered graphics workloads, and applies those stored resource allocations when the same or a similar graphics workload is received subsequently by the GPU.