Patents by Inventor Mark S. Singer

Mark S. Singer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITION OF LEUKOCYTE ADHESION
    Publication number: 20120328632
    Abstract: This invention relates to the inhibition of intercellular adhesion mediated by L-selectin by administering a newly identified L-selectin ligand, CD34. More particularly, the invention concerns a method for inhibiting leukocyte adhesion to endothelial cells by administering an effective amount of an isolated, purified CD34 polypeptide or an antibody capable of binding native CD34.
    Type: Application
    Filed: December 21, 2011
    Publication date: December 27, 2012
    Applicant: Genentech, Inc.
    Inventors: Laurence A. Lasky, Susanne Baumhueter, Steven D. Rosen, Mark S. Singer
  • Inhibition of leukocyte adhesion
    Publication number: 20080241143
    Abstract: This invention relates to the inhibition of intercellular adhesion mediated by L-selectin by administering a newly identified L-selectin ligand, CD34. More particularly, the invention concerns a method for inhibiting leukocyte adhesion to endothelial cells by administering an effective amount of an isolated, purified CD34 polypeptide or an antibody capable of binding native CD34.
    Type: Application
    Filed: September 26, 2007
    Publication date: October 2, 2008
    Inventors: Laurence A. Lasky, Susanne Baumhueter, Steven D. Rosen, Mark S. Singer
  • Inhibition of leukocyte adhesion
    Publication number: 20040141966
    Abstract: This invention relates to the inhibition of intercellular adhesion mediated by L-selectin by administering a newly identified L-selectin ligand, CD34. More particularly, the invention concerns a method for inhibiting leukocyte adhesion to endothelial cells by administering an effective amount of an isolated, purified CD34 polypeptide or an antibody capable of binding native CD34.
    Type: Application
    Filed: January 15, 2003
    Publication date: July 22, 2004
    Applicant: Genentech, Inc.; The Regents of the University of California
    Inventors: Laurence A. Lasky, Susanne Baumhueter, Steven D. Rosen, Mark S. Singer
  • Soluble lymphocyte homing receptors
    Patent number: 5840844
    Abstract: DNA isolates coding for the lymphocyte homing receptor and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the lymphocyte homing receptor useful in therapeutic or diagnostic compositions.
    Type: Grant
    Filed: August 10, 1995
    Date of Patent: November 24, 1998
    Assignee: Genentech, Inc. University of California
    Inventors: Laurence A. Lasky, Steven D. Rosen, Scott E. Stachel, Mark S. Singer
  • Method for purification of L-selectin ligands
    Patent number: 5652343
    Abstract: The invention relates to glycoprotein ligands of selectins. The invention further relates to methods and means for preparing and to nucleic acids encoding these ligands. The invention further concerns a method of treating a symptom or condition associated with excessive binding of circulating leukocytes to endothelial cells by administering to a patient in need of such treatment a glycoprotein ligand of a selectin.
    Type: Grant
    Filed: August 23, 1994
    Date of Patent: July 29, 1997
    Assignees: Genentech, Inc., The Regents of the University of California
    Inventors: Laurence A. Lasky, Yasuyuki Imai, Steven D. Rosen, Mark S. Singer
  • Selectin ligands
    Patent number: 5484891
    Abstract: The invention relates to glycoprotein ligands of selectins. The invention further relates to methods and means for preparing and to nucleic acids encoding these ligands. The invention further concerns a method of treating a symptom or condition associated with excessive binding of circulating leukocytes to endothelial cells by administering to a patient in need of such treatment a glycoprotein ligand of a selectin.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: January 16, 1996
    Assignees: Genentech, Inc., The Regents of the University of California
    Inventors: Laurence A. Lasky, Yasuyuki Imai, Steven D. Rosen, Mark S. Singer
  • DNA sequence encoding a selectin ligand
    Patent number: 5304640
    Abstract: The invention relates to glycoprotein ligands of selectins. The invention further relates to methods and means for preparing and to nucleic acids encoding these ligands. The invention further concerns a method of treating a symptom or condition associated with excessive binding of circulating leukocytes to endothelial cells by administering to a patient in need of such treatment a glycoprotein ligand of a selectin.
    Type: Grant
    Filed: February 13, 1992
    Date of Patent: April 19, 1994
    Assignees: Genentech, Inc., Regents of the University of California
    Inventors: Laurence A. Lasky, Yasuyuki Imai, Steven D. Rosen, Mark S. Singer
  • Lymphocyte homing receptors
    Patent number: 5216131
    Abstract: DNA isolates coding for the lymphocyte homing receptor and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the lymphocyte homing receptor useful in therapeutic or diagnostic compositions.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: June 1, 1993
    Assignee: Genentech, Inc.
    Inventors: Laurence A. Lasky, Steven D. Rosen, Scott E. Stachel, Mark S. Singer, Ted A. Yednock
  • DNA sequence encoding a functional domain of a lymphocyte homing receptor
    Patent number: 5098833
    Abstract: DNA isolates coding for a lymphocyte homing receptor and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the lymphocyte homing receptor useful in therapeutic or diagnostic compositions.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: March 24, 1992
    Assignees: Genentech, Inc., The Regents of the University of California
    Inventors: Laurence A. Lasky, Steven D. Rosen, Scott E. Stachel, Mark S. Singer, Ted A. Yednock