Patents by Inventor Mark S. Tichenor

Mark S. Tichenor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES
    Publication number: 20240174662
    Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (II) and compounds of formula (III), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.
    Type: Application
    Filed: January 31, 2022
    Publication date: May 30, 2024
    Inventors: Genesis M. BACANI, Wenying CHAI, De Michael CHUNG, Steven D. GOLDBERG, Gavin HIRST, Virendar KAUSHIK, Eduardo V. MERCADO-MARIN, Donald RAYMOND, Mark SEIERSTAD, Russel C. SMITH, Thomas SUNDBERG, Mark S. TICHENOR, Jennifer D. VENABLE, Jianmei WEI, Ramnik XAVIER
  • SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES
    Publication number: 20240158392
    Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.
    Type: Application
    Filed: January 31, 2022
    Publication date: May 16, 2024
    Inventors: Genesis M. BACANI, Wenying CHAI, De Michael CHUNG, Steven D. GOLDBERG, Gavin HIRST, Virnedar KAUSHIK, Eduardo V. MERCADO-MARIN, Donald RAYMOND, Mark SEIERSTAD, Russel C. SMITH, Thomas SUNDBERG, Mark S. TICHENOR, Jennifer D. VENABLE, Jianmei WEI, Ramnik XAVIER, Helena C. STEFFENS
  • Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
    Patent number: 11827638
    Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: November 28, 2023
    Assignee: Janssen Pharmaceutica NV
    Inventors: Genesis M. Bacani, Wenying Chai, Tatiana Koudriakova, Paul J. Krawczuk, Kevin D. Kreutter, Kristi Leonard, Michele C. Rizzolio, Mark Seierstad, Russell C. Smith, Mark S. Tichenor, Jennifer D. Venable, Aihua Wang
  • Small molecule inhibitors of the JAK family of kinases
    Patent number: 11787807
    Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK.
    Type: Grant
    Filed: July 15, 2021
    Date of Patent: October 17, 2023
    Assignee: Janssen Pharmaceutica NV
    Inventors: Philippe Fernandes, Paul J. Krawczuk, Mark S. Tichenor
  • CRYSTAL STRUCTURE OF BTK PROTEIN AND BINDING POCKETS THEREOF
    Publication number: 20230175038
    Abstract: The present invention provides a crystal structure of human BTK with space group space group p 2 21 21 and has unit cell parameters a=38.155±2?; b=72.394±2?; c=103.946±2?; a=90°; b=90°; g=90°; the BTK protein is complexed with N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(S)-(6-isobutyl-4-methylpyridin-3-yl)-4-oxo-4,5-dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide.
    Type: Application
    Filed: December 7, 2022
    Publication date: June 8, 2023
    Inventors: Richard S. ALEXANDER, Cynthia MILLIGAN, Mark S. TICHENOR
  • INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHOD OF THEIR USE
    Publication number: 20230097422
    Abstract: The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).
    Type: Application
    Filed: March 25, 2022
    Publication date: March 30, 2023
    Inventors: Nidhi ARORA, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Kevin D. Kreutter, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J.M. Wiener
  • INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE
    Publication number: 20230013755
    Abstract: The present disclosure is directed to the use of a compound of Formula (III) in the treatment of malignancies.
    Type: Application
    Filed: June 2, 2022
    Publication date: January 19, 2023
    Inventors: Sriram BALASUBRAMANIAN, Ivo CORNELISSEN, Yue GUO, Jocelyn H. LEU, Kathryn E. PACKMAN, James Alexander PALMER, Ulrike PHILIPPAR, Navin RAO, Mark S. TICHENOR, Jennifer D. VENABLE, John J. M. WIENER, Xin MIAO
  • INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE
    Publication number: 20230012167
    Abstract: The present disclosure is directed to the use of a compound of Formula (III) in the treatment of DLBCL.
    Type: Application
    Filed: June 30, 2022
    Publication date: January 12, 2023
    Inventors: Jacqueline Cirillo BUSSOLARI, Ulrike PHILIPPAR, Andrew STEELE, Mark S. TICHENOR
  • Inhibitors of Bruton's tyrosine kinase and methods of their use
    Patent number: 11319329
    Abstract: The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: May 3, 2022
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Kevin D. Kreutter, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J. M. Wiener
  • Small Molecule Inhibitors of the JAK Family of Kinases
    Publication number: 20210340143
    Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
    Type: Application
    Filed: June 23, 2021
    Publication date: November 4, 2021
    Inventors: Tatiana Koudriakova, Kevin D. Kreutter, Kristi Leonard, Michele C. Rizzolio, Russell C. Smith, Mark S. Tichenor, Aihua Wang
  • SMALL MOLECULE INHIBITORS OF THE JAK FAMILY OF KINASES
    Publication number: 20210340144
    Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK.
    Type: Application
    Filed: July 15, 2021
    Publication date: November 4, 2021
    Inventors: Philippe FERNANDES, Paul J. Krawczuk, Mark S. Tichenor
  • Small molecule inhibitors of the JAK family of kinases
    Patent number: 11066406
    Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: July 20, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Philippe Fernandes, Paul J. Krawczuk, Mark S. Tichenor
  • Small molecule inhibitors of the JAK family of kinases
    Patent number: 11059823
    Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: July 13, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Tatiana Koudriakova, Kevin D. Kreutter, Kristi Leonard, Michele C. Rizzolio, Russell C. Smith, Mark S. Tichenor, Aihua Wang
  • IMIDAZOPYRROLOPYRIDINE AS INHIBITORS OF THE JAK FAMILY OF KINASES
    Publication number: 20210206768
    Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
    Type: Application
    Filed: March 16, 2021
    Publication date: July 8, 2021
    Inventors: Genesis M. Bacani, Wenying Chai, Tatiana Koudriakova, Paul J. Krawczuk, Kevin D. Kreutter, Kristi Leonard, Michele C. Rizzolio, Mark Seierstad, Russell C. Smith, Mark S. Tichenor, Jennifer D. Venable, Aihua Wang
  • Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
    Patent number: 10981911
    Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: April 20, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Genesis M. Bacani, Wenying Chai, Tatiana Koudriakova, Paul J. Krawczuk, Kevin D. Kreutter, Kristi Leonard, Michele C. Rizzolio, Mark Seierstad, Russell C. Smith, Mark S. Tichenor, Jennifer D. Venable, Aihua Wang
  • INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE
    Publication number: 20210101910
    Abstract: The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).
    Type: Application
    Filed: May 13, 2020
    Publication date: April 8, 2021
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Kevin D. Kreutter, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J.M. Wiener
  • Inhibitors of Bruton's tyrosine kinase and method of their use
    Patent number: 10934310
    Abstract: The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: March 2, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Min Cai, Wei Chen, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Kevin D. Kreutter, Gang Li, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J. M. Wiener, Yao Wu, Kun Xiao, Feihuang Zhang, Yaoping Zhu
  • Inhibitors of Bruton's tyrosine kinase and methods of their use
    Patent number: 10822348
    Abstract: The present disclosure is directed to compounds of formula I? and methods of their use and preparation, as well as compositions comprising compounds of formula I?.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: November 3, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Min Cai, Wei Chen, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Baoyu Hao, Kevin D. Kreutter, Gang Li, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J. M. Wiener, Yao Wu, Yaoping Zhu, Feihuang Zhang, Zheng Zhang, Kun Xiao
  • Inhibitors of Bruton's tyrosine kinase and method of their use
    Patent number: 10800792
    Abstract: The present disclosure is directed to compounds of formula I? and methods of their use and preparation, as well as compositions comprising compounds of formula I?.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: October 13, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Min Cai, Wei Chen, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Baoyu Hao, Kevin D. Kreutter, Gang Li, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J. M. Wiener, Yao Wu, Yaoping Zhu, Feihuang Zhang, Zheng Zhang, Kun Xiao
  • Inhibitors of Bruton's tyrosine kinase and method of their use
    Patent number: 10717745
    Abstract: The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: July 21, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Min Cai, Wei Chen, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Kevin D. Kreutter, Gang Li, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J. M. Wiener, Yao Wu, Kun Xiao, Feihuang Zhang, Yaoping Zhu