Abstract: The present invention relates to compounds that bind to TDP-43 and may have a therapeutic effect in treating a human disease, such as amyotrophic lateral sclerosis, frontotemporal lobar degeneration, hippocampal sclerosis of aging, chronic traumatic encephalopathy, inclusion body myositis, Alzheimer's disease, and/or Alzheimer's disease related disorders.

Abstract: Burners and methods of making burner bodies via a focused beam are disclosed. In an aspect, a burner includes (a) a burner body and (b) at least one connector configured to supply at least a fuel and an oxidizer to the burner body. The burner body includes (1) a plurality of passageways; (2) a first major surface; (3) a plurality of ports at the first major surface, each port defined by an end of one of the passageways; and either: (4a) at least one heating element in or adjacent to at least one of the plurality of passageways that increases the temperature of a wall of the at least one of the plurality of passageways; or (4b) a cooling chamber directly adjacent to three or more of the plurality of passageways. The burner body includes a number of layers of metal directly bonded to each other.

Abstract: Burners and methods of making burner bodies via a focused beam are disclosed. In an aspect, a burner includes (a) a burner body and (b) at least one connector configured to supply at least a fuel and an oxidizer to the burner body. The burner body includes (1) a plurality of passageways; (2) a first major surface; (3) a plurality of ports at the first major surface, each port defined by an end of one of the passageways; and either: (4a) at least one heating element in or adjacent to at least one of the plurality of passageways that increases the temperature of a wall of the at least one of the plurality of passageways; or (4b) a cooling chamber directly adjacent to three or more of the plurality of passageways. The burner body includes a number of layers of metal directly bonded to each other.

Abstract: A heat-treated non-oriented principal film including a cast (co)polymeric component that is not capable of thermally-induced self-forming. The heat-treated principal film has first and second opposed major faces and at least one modification zone on the first major face, each modification zone including a central portion and a rim portion surrounding the central portion. Each rim portion is surrounded by a land portion. An average thickness of each rim portion is greater than an average thickness of the land portion surrounding each modification zone, and an average thickness of each central portion is less than the average thickness of the land portion, or zero. The first major face of the heat-treated principal film may be positioned in contact with an oriented carrier film including a molecularly-oriented (co)polymer that exhibits a relaxation temperature (Tr). Methods of making such films and hand-tearable adhesive articles including such films are also disclosed.

Abstract: An oriented heat-treated principal film capable of thermally-induced self-forming, including one or more (co)polymers and exhibiting a relaxation temperature (Tr), the oriented heat-treated principal film having opposed first and second major faces, a land portion on the second major face and one or more modification zones on the second major face. A cross-linked (co)polymeric carrier layer is in contact with the first major face. Each modification zone includes a central closed portion and a rim portion surrounding the central closed portion and being surrounded by a land portion. An average thickness of each rim portion is greater than an average thickness of the land portion surrounding the central closed portion. An average thickness of each central closed portion is less than the average thickness of the land portion surrounding the central portion. Methods for making such films and adhesive articles comprising such films are also disclosed.

Abstract: Burners and methods of making burner bodies via a focused beam are disclosed. In an aspect, a burner includes (a) a burner body and (b) at least one connector configured to supply at least a fuel and an oxidizer to the burner body. The burner body includes (1) a plurality of passageways; (2) a first major surface; (3) a plurality of ports at the first major surface, each port defined by an end of one of the passageways; and either: (4a) at least one heating element in or adjacent to at least one of the plurality of passageways that increases the temperature of a wall of the at least one of the plurality of passageways; or (4b) a cooling chamber directly adjacent to three or more of the plurality of passageways. The burner body includes a number of layers of metal directly bonded to each other.

Abstract: A principal film comprising a first polymeric component wherein the principal film has: (1) first and second major faces; (2) a land portion wherein the principal film is capable of thermally-induced self-forming; and (3) one or more modification zones, each comprising a central portion and a rim portion surrounding the central portion and being surrounded by land portion, wherein the average thickness of each rim portion is greater than the average thickness of the land portion surrounding the modification zone, the average thickness of each central portion is less than the average thickness of the land portion surrounding the modification zone and is greater than zero. Also methods for making such films and articles comprising such films.

Abstract: A coating composition is disclosed. The coating composition includes a poly(methyl methacrylate) polymer or copolymer having a weight average molecular weight of at least 50,000 grams per mole; monomer comprising at least one of an alkylene diacrylate, alkylene dimethacrylate, cycloalkylene diacrylate, or cycloalkylenedimethacrylate, wherein the at least one of an alkylene diacrylate, alkylene dimethacrylate, cycloalkylene diacrylate, or cycloalkylenedimethacrylate provides at least 80 percent by weight of the monomer; and a stabilizer against ultraviolet light. An article including a coating on a surface of a substrate and a method of making the article are also disclosed. The coating on the surface of the substrate is obtained by curing the disclosed coating composition.

Abstract: Material comprising sub-micrometer particles dispersed in a polymeric matrix. The materials are useful in article, for example, for numerous applications including display applications (e.g., liquid crystal displays (LCD), light emitting diode (LED) displays, or plasma displays); light extraction; electromagnetic interference (EMI) shielding, ophthalmic lenses; face shielding lenses or films; window films; antireflection for construction applications; and construction applications or traffic signs.

Abstract: A principal film comprising a first polymeric component wherein the principal film has: (1) first and second major faces; (2) a land portion wherein the principal film is capable of thermally-induced self- forming; and (3) one or more modification zones, each comprising a central portion and a rim portion surrounding the central portion and being surrounded by land portion, wherein the average thickness of each rim portion is greater than the average thickness of the land portion surrounding the modification zone, the average thickness of each central portion is less than the average thickness of the land portion surrounding the modification zone and is greater than zero. Also methods for making such films and articles comprising such films.

Abstract: A protective film includes a base layer and a wear layer, the wear layer comprising a UV cured hardcoat resin, and the UV cured hardcoat resin comprising surface modified silica nanoparticles. The protective film may comprise a pressure sensitive adhesive for adhesion to a floor. The protective film may be used, for example, as a protective floor finish.

Abstract: Methods of bonding polyester substrates together, comprising externally delivering thermal energy onto the bonding surfaces of the substrates and bringing the bonding surfaces into proximity with each other and bonding the substrates to each other.

Abstract: Methods of bonding polyester substrates together, comprising externally delivering thermal energy onto the bonding surfaces of the substrates and bringing the bonding surfaces into proximity with each other and bonding the substrates to each other.

Abstract: A coating composition is disclosed. The coating composition includes a poly(methyl methacrylate) polymer or copolymer having a weight average molecular weight of at least 50,000 grams per mole; monomer comprising at least one of an alkylene diacrylate, alkylene dimethacrylate, cycloalkylene diacrylate, or cycloalkylenedimethacrylate, wherein the at least one of an alkylene diacrylate, alkylene dimethacrylate, cycloalkylene diacrylate, or cycloalkylenedimethacrylate provides at least 80 percent by weight of the monomer; and a stabilizer against ultraviolet light. An article including a coating on a surface of a substrate and a method of making the article are also disclosed. The coating on the surface of the substrate is obtained by curing the disclosed coating composition.

Abstract: A monolithic multilayer article includes a thermoformable cellular polyester core layer and an oriented polyester skin layer on at least one major side of the polyester core layer.

Abstract: Material comprising sub-micrometer particles dispersed in a polymeric matrix. The materials are useful in article, for example, for numerous applications including display applications (e.g., liquid crystal displays (LCD), light emitting diode (LED) displays, or plasma displays); light extraction; electromagnetic interference (EMI) shielding, ophthalmic lenses; face shielding lenses or films; window films; antireflection for construction applications; and construction applications or traffic signs.

Abstract: A transparent anti-reflective structured film comprising a structured film substrate having a structured face, with anti-reflective structures defining a structured surface. The structured face is anti-reflective to light, with at least a substantial portion of the structured surface comprising a glass-like surface. At least the anti-reflective structures comprise a cross-linked silicone elastomeric material, and the glass-like surface comprises an SiO2 stoichiometry. The glass-like surface is coated with a coating of at least one layer of agglomerates of silica nanoparticles, with the agglomerates comprising a three-dimensional porous network of silica nanoparticles, and the silica nanoparticles being bonded to adjacent silica nanoparticles. A light energy absorbing device comprising the transparent anti-reflective structured film disposed so as to be between a source of light energy and a light energy receiving face of a light absorber, when light energy is being absorbed by the light absorber.

Abstract: A transparent anti-reflective structured film (10) comprising a structured film substrate (12) having a structured face (14), with anti-reflective structures, for example, in the form of prismatic riblets (16) defining a structured surface. The structured face is anti-reflective to light, with at least a substantial portion of the structured surface comprising a glass-like surface. At least the anti-reflective structures comprise a cross-linked silicone elastomeric material and the glass-like surface comprises an Si02 stoichiometry. A solar light energy absorbing device is disclosed, comprising the transparent anti-reflective structured film disposed so as to be between a source of light energy and a light energy receiving face of a light absorber, when light energy is being absorbed by the light absorber.

Abstract: A method for forming an inorganic or hybrid organic/inorganic layer on a substrate, which method comprises applying a metal alkoxide to form a layer atop the substrate and exposing the metal alkoxide layer to heat from a catalytic combustion heater in the presence of water to cure the layer is provided.

Abstract: An apparatus and methods for flame-perforating films. A preferred embodiment of the apparatus includes a frame, support surface attached to the frame, where the support surface includes a plurality of lowered portions, a burner attached to the frame opposite the support surface, where the burner supports a flame, and where the flame includes a flame tip opposite the burner and a film contacting the support surface, where the flame of the burner is in contact with the film, where the burner is positioned such that the distance between an unimpinged flame tip of the flame and the burner is at least one-third greater than the distance between the film and the burner.