Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer autoimmune and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

Abstract: The present disclosure relates to methods of treating heat stock factor 1 (HSF1)-related diseases such as cancer, autoimmune and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

Abstract: The present disclosure relates to RNAi agents useful in methods of treating KRAS-related diseases such as a proliferative disease, including without limitation a solid or liquid cancer, adenocarcinoma, colorectal cancer, advanced and/or metastatic colorectal cancer, colon cancer, lung, non-small cell lung cancer and lung adenocarcinoma, acute myelogenous lung, bladder, brain, breast, cervical, endometrial, gastric, head and neck, kidney, leukemia, myelodysplastic syndrome, myeloid leukemia, liver, melanoma, ovarian, pancreatic, prostate, testicular, thyroid cancers, and cardio-facio-cutaneous (CFC) syndrome and Noonan syndrome, and similar and related diseases, using a therapeutically effective amount of a RNAi agent to KRAS.

Abstract: The windscreen wiper device includes a wiper element which is made of a flexible material and a carrier which operably supports the wiper element and biases the wiper element into a pre-curved position. A base is engaged with the carrier and at least one connector piece is releasably connectable with the base. The base includes a pair of holding elements which wrap around opposite lateral side edges of the carrier and a pair of laterally spaced side walls. The connector piece includes a pair of legs. A pair of projections are disposed in at least one of the side walls of the base and the legs of the connector piece and a pair of recesses are disposed on at least one of the side walls of the base and the legs of the connector piece for snappingly receiving the projections to releasably attach the connector piece with the base.

Abstract: The present disclosure relates to methods of treating heat stock factor 1 (HSF1)-related diseases such as cancer, autoimmune and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer, autoimmune and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

Abstract: The present disclosure relates to RNAi agents useful in methods of treating KRAS-related diseases such as a proliferative disease, including without limitation a solid or liquid cancer, adenocarcinoma, colorectal cancer, advanced and/or metastatic colorectal cancer, colon cancer, lung, non-small cell lung cancer and lung adenocarcinoma, acute myelogenous lung, bladder, brain, breast, cervical, endometrial, gastric, head and neck, kidney, leukemia, myelodysplastic syndrome, myeloid leukemia, liver, melanoma, ovarian, pancreatic, prostate, testicular, thyroid cancers, and cardio-facio-cutaneous (CFC) syndrome and Noonan syndrome, and similar and related diseases, using a therapeutically effective amount of a RNAi agent to KRAS.

Abstract: The windscreen wiper device includes a wiper element which is made of a flexible material and a carrier which operably supports the wiper element and biases the wiper element into a pre-curved position. A base is engaged with the carrier and at least one connector piece is releasably connectable with the base. The base includes a pair of holding elements which wrap around opposite lateral side edges of the carrier and a pair of laterally spaced side walls. The connector piece includes a pair of legs. A pair of projections are disposed in at least one of the side walls of the base and the legs of the connector piece and a pair of recesses are disposed on at least one of the side walls of the base and the legs of the connector piece for snappingly receiving the projections to releasably attach the connector piece with the base.

Abstract: Generally applicable methods for identifying physiologically relevant endogenous target molecules, are provided. The methods use both protein interaction assay steps and phenotypic assay steps. In some embodiments, protein interactions are detected utilizing yeast two hybrid techniques.