Abstract: In accordance with various embodiments of the disclosed subject matter, a system, device and platform for culturing and maintaining tissue representative cellular models combined with active fluidics mimicking body circulation. In combination, multiple chamber devices enable modeling of multi-organ communication, representative of in vivo conditions.

Abstract: The present application relates to methods for treating conditions characterized by reduced cerebral blood flow that include selecting a subject having a condition characterized by reduced cerebral blood flow. A therapeutic agent that increases the levels of PIP2 is administered under conditions effective to treat the condition in the subject. Also disclosed are methods for treating CADASIL as well as methods for restoring cerebral blood flow and functional hyperemia.

Abstract: A system for preparing and holding specimens for microscopic analysis including a capsule having an open end, an opposite end including at least one aperture and a reservoir. The system also includes an insert with a base including at least one aperture. The insert fits within and engages an inner wall of the reservoir to secure the insert within the reservoir. The system also includes an insertion tool configured to engage the insert. The insertion tool is sized to position the insert within the reservoir at a variety of positions within the reservoir. The insertion tool will disengage the insert once the insert is positioned within the reservoir. A method of positioning a specimen within a capsule for processing the specimen in preparation for microscopic analysis. A tray for holding a plurality of pipette tips in such a way that a lower end of each pipette tip is sealed.

Abstract: A device for holding a specimen holder, the device including a body with a slot formed therein. The slot includes an interior for receiving the specimen holder which may be a flat disk with edges and a pair of opposing sides. The disk may be made of a resilient deformable material. The slot may be sized to receive the specimen holder through an open top end and may taper from top bottom, such that the bottom end of the slot is smaller than the specimen holder. The slot further configured to contact the specimen holder along edges of the specimen holder and to allow some sideways deformation of the specimen holder without either side of the specimen holder distant from the edges coming into contact with the interior of the slot.

Abstract: A system for preparing and holding specimens for microscopic analysis including a capsule having an open end, an opposite end including at least one aperture and a reservoir. The system also includes an insert with a base including at least one aperture. The insert fits within and engages an inner wall of the reservoir to secure the insert within the reservoir. The system also includes an insertion tool configured to engage the insert. The insertion tool is sized to position the insert within the reservoir at a variety of positions within the reservoir. The insertion tool will disengage the insert once the insert is positioned within the reservoir. A method of positioning a specimen within a capsule for processing the specimen in preparation for microscopic analysis. A tray for holding a plurality of pipette tips in such a way that a lower end of each pipette tip is sealed.

Abstract: A device for holding a specimen holder, the device including a body with a slot formed therein. The slot includes an interior for receiving the specimen holder which may be a flat disk with edges and a pair of opposing sides. The disk may be made of a resilient deformable material. The slot may be sized to receive the specimen holder through an open top end and may taper from top bottom, such that the bottom end of the slot is smaller than the specimen holder. The slot further configured to contact the specimen holder along edges of the specimen holder and to allow some sideways deformation of the specimen holder without either side of the specimen holder distant from the edges coming into contact with the interior of the slot.

Abstract: Adornments are applied to shapes in a diagram that graphically displays data about those shapes. Once the adornments are applied to a shape, the information displayed is automatically updated as the underlying shape data changes. The appearance of the diagram is updated automatically when the user updates the data for their shapes. The set of adornments that may be applied to shapes is extensible. A mechanism and interface is defined for creating additional adornments that have customized looks or behaviors.

Abstract: A method comprises receiving a bit sequence associated with at least one file, the bit sequence comprising payload data in a compressed format and characterization data that maps the compressed format of the payload data. The method continues by encrypting the characterization data that maps the compressed format of the payload data. The method concludes by transmitting the bit sequence such that the characterization data is encrypted and at least a portion of the payload data is unencrypted.

Abstract: A computer-based method and system of processing records read respectively from first and second related tables of a database includes determining whether data contained in the records read from the first or second tables is unevenly distributed. Records corresponding to evenly distributed data are searched for matches using a first set of instances of the hash-join operator, and records corresponding to data which is unevenly distributed are searched for matches using a second set of instances of a hash-join operator.

Abstract: A computer-based method and system of processing records read respectively from first and second related tables of a database includes determining whether data contained in the records read from the first or second tables is unevenly distributed. Records corresponding to evenly distributed data are searched for matches using a first set of instances of the hash-join operator, and records corresponding to data which is unevenly distributed are searched for matches using a second set of instances of a hash-join operator.