Abstract: Provided herein are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, comprising disabling myeloid cells using an anti-Triggering Receptor Expressed on Myeloid Cells 1 (TREM1) antibody.

Abstract: Disclosed herein is an integrated photonics device including an on-chip wavelength stability monitor. The wavelength stability monitor may include one or more interferometric components, such as Mach-Zehnder interferometers and can be configured to select among the output signals from the interferometric components for monitoring the wavelength emitted by a corresponding photonic component, such as a light source. The selection may be based on a slope of the output signal and in some examples may correspond to a working zone at or around a wavelength or wavelength range. In some examples, the interferometric components can be configured with different phase differences such that the corresponding working zones have different wavelengths. In some examples, the slopes of the output signals may be weighted based on the steepness of the slope and all of the output signals may include information for wavelength locking the measured wavelength to the target wavelength.

Abstract: Configurations for an optical system used for guiding light and reducing back-reflection back in an output waveguide is disclosed. The optical system may include an output waveguide defined in a slab waveguide. The output waveguide may terminate before an output side of the slab waveguide, which may reduce the back-reflection of light from the output side back into the output waveguide. The output side may define an optical element that may steer the output light. The optical element may collimate the output light, cause the output light to converge, or cause the output light to diverge.

Abstract: An example embodiment of a turbine engine assembly includes a low spool including a low spool accessory drive gear driven by a low rotor shaft, a high spool including a high spool accessory drive gear driven by a high rotor shaft concentric around a portion of the low rotor shaft, and a differential gear assembly adapted to offtake power from rotation of one or both of the low spool and the high spool to drive one or more accessory loads. The differential gear assembly includes a differential bullgear and one or more idler gears each including a plurality of teeth meshed with the low spool accessory drive gear and the high spool accessory drive gear, and a bearing surface. The differential bull gear includes a plurality of teeth and a corresponding at least one bearing surface engaging with the bearing surface of each of the one or more idler gears. The plurality of teeth are adapted to mesh with an accessory drive system to transfer the power offtake and drive the one or more accessory loads.

Abstract: A gas turbine engine is disclosed. In various embodiments, the gas turbine engine includes a high pressure turbine having a first stage and a second stage, the first stage connected to a high pressure turbine first stage spool and the second stage connected to a high pressure turbine second stage spool; a high pressure compressor connected to a high pressure compressor spool; and a differential system having a first stage input gear connected to the high pressure turbine first stage spool, a second stage input gear connected to the high pressure turbine second stage spool and an output gear connected to the high pressure compressor spool.

Abstract: A turbofan engine includes a fan section including a plurality of fan blades, a first spool including a first turbine section, a second spool including a second turbine section, a first electric machine, and a second electric machine. A gear system is coupled between the first spool, the second spool, the first electric machine, the second electric machine and the fan section for driving the fan section.

Abstract: A gas turbine engine is disclosed. In various embodiments, the gas turbine engine includes a high pressure turbine having a first stage and a second stage, the first stage connected to a high pressure turbine first stage spool and the second stage connected to a high pressure turbine second stage spool; a high pressure compressor connected to a high pressure compressor spool; and a differential system having a first stage input gear connected to the high pressure turbine first stage spool, a second stage input gear connected to the high pressure turbine second stage spool and an output gear connected to the high pressure compressor spool.

Abstract: A turbofan engine includes a fan section including a plurality of fan blades, a first spool including a first turbine section, a second spool including a second turbine section, a first electric machine, and a second electric machine. A gear system is coupled between the first spool, the second spool, the first electric machine, the second electric machine and the fan section for driving the fan section.

Abstract: An example embodiment of a turbine engine assembly includes a low spool including a low spool accessory drive gear driven by a low rotor shaft, a high spool including a high spool accessory drive gear driven by a high rotor shaft concentric around a portion of the low rotor shaft, and a differential gear assembly adapted to offtake power from rotation of one or both of the low spool and the high spool to drive one or more accessory loads. The differential gear assembly includes a differential bullgear and one or more idler gears each including a plurality of teeth meshed with the low spool accessory drive gear and the high spool accessory drive gear, and a bearing surface. The differential bull gear includes a plurality of teeth and a corresponding at least one bearing surface engaging with the bearing surface of each of the one or more idler gears. The plurality of teeth are adapted to mesh with an accessory drive system to transfer the power offtake and drive the one or more accessory loads.