Abstract: Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.

Abstract: One aspect of the present invention provides a continuous process for producing a fruit and/or vegetable paste comprising separating a continuous stream of fruit and/or vegetable juice into a low solids serum stream and a high solids pulp stream and concentrating the serum stream in a concentrator before recombining it with the pulp stream to produce a recombined stream; wherein the Brix concentration of the recombined stream is automatically adjusted to a constant level by combining the concentrated serum stream, the pulp stream and/or the recombined stream with an adjustable amount of a diluent stream and by automatically adjusting the flow rate of the diluent stream to compensate for fluctuations in the Brix concentration of the pulp stream and/or the concentrated serum stream. The invention also provides a plant for the production of a fruit and/or vegetable paste that can suitably be used to operate the aforementioned continuous process.