Patents by Inventor Mark Verdecia

Mark Verdecia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERING OF MONOMERIC, RED-SHIFTED, AND BRIGHTER VARIANTS OF iRFP USING STRUCTURE-GUIDED MULTI-SITE MUTAGENESIS
    Publication number: 20200181205
    Abstract: The invention in at least one embodiment includes a method to convert a fluorescent protein into a modified fluorescent protein in a monomeric state where a dimerization interface is identified in a template protein in a homodimer state. One or more targeted mutation(s) are introduced at the dimerization interface to disrupt dimerization and favor the monomeric state. In another embodiment of the invention, one or more chromophore binding domains are identified in a template protein. One or more targeted mutations are introduced in the chromophore binding domain(s) to change the configuration of a biliverdin chromophore in the template protein from a 15Z anti configuration to a 15E anti configuration.
    Type: Application
    Filed: October 13, 2019
    Publication date: June 11, 2020
    Inventors: Elad Firnberg, Oliver C. Rogers, Mark A. Verdecia
  • Pin1-modulating compounds and methods of use thereof
    Patent number: 8258099
    Abstract: The invention is directed to peptide modulators of Pin1 and Pin1-related proteins and the use of such modulators for treatment of Pin1 associated states, e.g., for the treatment of cancer or neurodegenerative disease.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: September 4, 2012
    Assignees: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften E.V., Beth Israel Deaconess Medical Center, Inc., The Salk Institute for Biological Studies
    Inventors: Kun Ping Lu, Robert K. Suto, Janusz M. Sowadski, Gunter S. Fischer, Joseph P. Noel, Mark Verdecia
  • Pin1-Modulating Compounds and Methods of Use Thereof
    Publication number: 20080214470
    Abstract: The invention is directed to peptide modulators of Pin1 and Pin1-related proteins and the use of such modulators for treatment of Pin1 associated states, e.g., for the treatment of cancer or neurodegenerative disease.
    Type: Application
    Filed: July 15, 2005
    Publication date: September 4, 2008
    Applicants: VERNALIS PLC, BETH ISRAEL DEACONESS MEDICAL CENTER, THE SALK INSTITUTE FOR BIOLOGICAL STUDIES
    Inventors: Kun Ping Lu, Robert K. Suto, Janusz M. Sowadski, Gunter S. Fischer, Joseph P. Noel, Mark Verdecia
  • Crystal structure of WW domains and methods of use thereof
    Patent number: 7127357
    Abstract: A WW domain crystal structure of Pin1 is provided. In addition, methods of using the crystal structure and atomic coordinates for the development of WW domain binding agents is also provided. Also provided are computer programs on computer readable medium for use in developing WW domain binding agents.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: October 24, 2006
    Assignee: The Salk Institute for Biological Studies
    Inventors: Joseph P. Noel, Mark A. Verdecia