Patents by Inventor Mark Vreeke
Mark Vreeke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230329593Abstract: A device for delivery of an insulin or insulin analog formulation and measurement of subcutaneous glucose concentration may comprise a hollow tube, and an amperometric glucose sensor located proximal to a distal end of the hollow tube. The amperometric glucose sensor may comprise a redox mediator and an enzyme comprising glucose oxidase or glucose dehydrogenase. An applied bias potential may allow an electrode layer of the amperometric glucose sensor to undergo substantially no electropolymerization of an excipient of the insulin or insulin analog formulation during continuous operation of amperometric glucose sensor. A sensitivity of the amperometric glucose sensor to the subcutaneous glucose concentration may be maintained in presence of the insulin or insulin analog formulation.Type: ApplicationFiled: February 22, 2023Publication date: October 19, 2023Inventors: William Kenneth Ward, Robert S. Cargill, Gabriel Heinrich, Sheila Benware, Mark Vreeke, Joseph D. Kowalski, Thomas Seidl
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Publication number: 20220080123Abstract: In an aspect, the present disclosure provides a combined drug delivery cannula and continuous glucose sensor that measures glucose without interference from the drug excipient, said cannula being a hollow tube, the outer wall of which includes: an electrode layer with at least one indicating electrode, said layer underlying a redox-catalytic layer that includes an osmium compound bound to a ligand, and either glucose oxidase or glucose dehydrogenase.Type: ApplicationFiled: August 24, 2021Publication date: March 17, 2022Inventors: William Kenneth WARD, Robert S. CARGILL, Gabriel HEINRICH, Sheila BENWARE, Mark VREEKE, Joseph D. KOWALSKI, Thomas SEIDL
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Patent number: 11135369Abstract: This disclosure teaches the concept, and method of creating, a dual use device intended for persons who take insulin. In one embodiment, the novel device is an insulin delivery cannula, the outer wall of which contains electrodes, chemical compounds and electrical interconnects that allow continuous glucose sensing and delivery of data to a remote device. Heretofore, the main problem in attempting to sense glucose at the site of insulin delivery has been the high current resulting from oxidation by the sensor of the preservatives in the insulin formulations. One means of eliminating these interferences is to poise the indicating electrode(s) of the sensor at a bias sufficiently low to avoid the signal from oxidation of the preservatives. One way of obtaining a glucose signal at a low bias is to use an osmium-ligand-polymer complex instead of conventional hydrogen peroxide sensing.Type: GrantFiled: August 13, 2020Date of Patent: October 5, 2021Assignee: PACIFIC DIABETES TECHNOLOGIES INCInventors: William Kenneth Ward, Robert S. Cargill, Gabriel Heinrich, Sheila Benware, Mark Vreeke, Joseph D. Kowalski, Thomas Seidl
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Publication number: 20200368431Abstract: This disclosure teaches the concept, and method of creating, a dual use device intended for persons who take insulin. In one embodiment, the novel device is an insulin delivery cannula, the outer wall of which contains electrodes, chemical compounds and electrical interconnects that allow continuous glucose sensing and delivery of data to a remote device. Heretofore, the main problem in attempting to sense glucose at the site of insulin delivery has been the high current resulting from oxidation by the sensor of the preservatives in the insulin formulations. One means of eliminating these interferences is to poise the indicating electrode(s) of the sensor at a bias sufficiently low to avoid the signal from oxidation of the preservatives. One way of obtaining a glucose signal at a low bias is to use an osmium-ligand-polymer complex instead of conventional hydrogen peroxide sensing.Type: ApplicationFiled: August 13, 2020Publication date: November 26, 2020Inventors: William Kenneth WARD, Robert S. CARGILL, Gabriel HEINRICH, Sheila BENWARE, Mark VREEKE, Joseph D. KOWALSKI, Thomas SEIDL
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Patent number: 10780222Abstract: This disclosure teaches the concept, and method of creating, a dual use device intended for persons who take insulin. In one embodiment, the novel device is an insulin delivery cannula, the outer wall of which contains electrodes, chemical compounds and electrical interconnects that allow continuous glucose sensing and delivery of data to a remote device. Heretofore, the main problem in attempting to sense glucose at the site of insulin delivery has been the high current resulting from oxidation by the sensor of the preservatives in the insulin formulations. One means of eliminating these interferences is to poise the indicating electrode(s) of the sensor at a bias sufficiently low to avoid the signal from oxidation of the preservatives. One way of obtaining a glucose signal at a low bias is to use an osmium-ligand-polymer complex instead of conventional hydrogen peroxide sensing.Type: GrantFiled: May 31, 2016Date of Patent: September 22, 2020Assignee: PACIFIC DIABETES TECHNOLOGIES INCInventors: William Kenneth Ward, Robert S Cargill, Gabriel Heinrich, Sheila Benware, Mark Vreeke, Joseph D. Kowalski, Thomas Seidl
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Publication number: 20160354542Abstract: This disclosure teaches the concept, and method of creating, a dual use device intended for persons who take insulin. In one embodiment, the novel device is an insulin delivery cannula, the outer wall of which contains electrodes, chemical compounds and electrical interconnects that allow continuous glucose sensing and delivery of data to a remote device. Heretofore, the main problem in attempting to sense glucose at the site of insulin delivery has been the high current resulting from oxidation by the sensor of the preservatives in the insulin formulations. One means of eliminating these interferences is to poise the indicating electrode(s) of the sensor at a bias sufficiently low to avoid the signal from oxidation of the preservatives. One way of obtaining a glucose signal at a low bias is to use an osmium-ligand-polymer complex instead of conventional hydrogen peroxide sensing.Type: ApplicationFiled: May 31, 2016Publication date: December 8, 2016Applicant: Pacific Diabetes TechnologiesInventors: William Kenneth Ward, Robert S. Cargill, Gabriel Heinrich, Sheila Benware, Mark Vreeke, Joseph D. Kowalski, Thomas Seidl
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Publication number: 20080318261Abstract: A sensor designed to determine the concentration of analyte in a sample having a volume of less than about 1 ?L. The sensor has a working electrode coated with a redox mediator that acts as an electron transfer agent between the analyte and the electrode. A second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. Various electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can be used to determine the analyte concentration. The sensor can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum.Type: ApplicationFiled: January 13, 2005Publication date: December 25, 2008Applicant: Abbott Diabetes Care Inc.Inventors: ADAM HELLER, BENJAMIN FELDMAN, JAMES SAY, MARK VREEKE
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Publication number: 20080295324Abstract: A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.Type: ApplicationFiled: October 30, 2007Publication date: December 4, 2008Applicant: Abbott Diabetes Care, Inc.Inventors: JAMES SAY, Michael F. Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip John Plante, Mark Vreeke
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Publication number: 20080091096Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: ApplicationFiled: November 16, 2007Publication date: April 17, 2008Applicant: Abbott Diabetes Care, Inc.Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip Plante, Mark Vreeke, Keith Friedman, Fredric Colman
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Publication number: 20080047129Abstract: A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.Type: ApplicationFiled: October 30, 2007Publication date: February 28, 2008Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip Plante, Mark Vreeke
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Publication number: 20080033271Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: ApplicationFiled: June 21, 2007Publication date: February 7, 2008Applicant: Abbott Diabetes Care, Inc.Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip Plante, Mark Vreeke, Keith Friedman, Fredric Colman
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Publication number: 20070249920Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: ApplicationFiled: June 21, 2007Publication date: October 25, 2007Applicant: Abbott Diabetes Care, Inc.Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip Plante, Mark Vreeke, Keith Friedman, Fredric Colman
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Publication number: 20070249919Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: ApplicationFiled: June 21, 2007Publication date: October 25, 2007Applicant: Abbott Diabetes Care, Inc.Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip Plante, Mark Vreeke, Keith Friedman, Fredric Colman
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Publication number: 20070244380Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: ApplicationFiled: June 21, 2007Publication date: October 18, 2007Applicant: Abbott Diabetes Care, Inc.Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip Plante, Mark Vreeke, Keith Friedman, Fredric Colman
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Publication number: 20070213610Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: ApplicationFiled: March 2, 2007Publication date: September 13, 2007Applicant: Abbott Diabetes Care, Inc.Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip Plante, Mark Vreeke, Keith Friedman, Fredric Colman
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Publication number: 20070208247Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: ApplicationFiled: April 30, 2007Publication date: September 6, 2007Applicant: ABBOTT DIABETES CARE, INC.Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Aria Behrad, Ephraim Heller, Phillip Plante, Mark Vreeke, Keith Friedman, Fredric Colman
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Publication number: 20070203410Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: ApplicationFiled: April 30, 2007Publication date: August 30, 2007Applicant: ABBOTT DIABETES CARE, INC.Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip Plante, Mark Vreeke, Keith Friedman, Fredric Colman
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Publication number: 20070203408Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: ApplicationFiled: April 30, 2007Publication date: August 30, 2007Applicant: ABBOTT DIABETES CARE, INC.Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip Plante, Mark Vreeke, Keith Friedman, Fredric Colman
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Publication number: 20070203411Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: ApplicationFiled: April 30, 2007Publication date: August 30, 2007Applicant: ABBOTT DIABETES CARE, INC.Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip Plante, Mark Vreeke, Keith Friedman, Fredric Colman
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Publication number: 20070191699Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: ApplicationFiled: April 3, 2007Publication date: August 16, 2007Applicant: Abbott Diabetes Care, Inc.Inventors: James Say, Michael Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip Plante, Mark Vreeke, Keith Friedman, Fredric Colman