Patents by Inventor Mark W. Grinstaff

Mark W. Grinstaff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition useful for in vivo delivery of biologics and methods employing same
    Patent number: 5498421
    Abstract: In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: March 12, 1996
    Assignee: Vivorx Pharmaceuticals, Inc.
    Inventors: Mark W. Grinstaff, Patrick Soon-Shiong, Michael Wong, Paul A. Sandford, Kenneth S. Suslick, Neil P. Desai
  • Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
    Patent number: 5439686
    Abstract: In accordance with the present invention, there are provided compositions for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug taxol) in which the pharmacologically active agent is delivered in a soluble form or in the form of suspended particles. In particular, the soluble form may comprise a solution of pharmacologically active agent in a biocompatible dispersing agent contained within a protein walled shell. Alternatively, the protein walled shell may contain particles of taxol. In another aspect, the suspended form comprises particles of pharmacologically active agent in a biocompatible aqueous liquid.
    Type: Grant
    Filed: February 22, 1993
    Date of Patent: August 8, 1995
    Assignee: VivoRx Pharmaceuticals, Inc.
    Inventors: Neil P. Desai, Patrick Soon-Shiong, Paul A. Sandford, Mark W. Grinstaff, Kenneth S. Suslick
  • Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
    Patent number: 5362478
    Abstract: In accordance with the present invention, compositions comprising fluorine-containing magnetic resonance imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI). Fluorinated compounds in general are hydrophobic and as such have limited water solubility; thus the invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery. The shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, fluorocarbon filled polymeric shells of the invention can be used to measure and monitor local oxygen and temperature.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: November 8, 1994
    Assignee: Vivorx Pharmaceuticals, Inc.
    Inventors: Neil P. Desai, Patrick Soon-Shiong, Paul A. Sandford, Mark W. Grinstaff, Kenneth S. Suslick