Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

Abstract: The invention relates to a segmented packing ring for sealed packages, comprising at least two annular segments (1), which, in the assembled state, are held together in the circumferential direction by means of springs (3). According to the invention, the assembly may be simplified and relatively small springs used as protection against damage as a result of spring breakages, whereby, at each contact point (2) of adjacent annular segments (1), at least one separate tension spring (3) is arranged between anchor elements (5) provided on both ends in the region of the ends (4) of the annular segments (1) and the fixing of the tension springs (3) to the anchor elements (5) has a preferably clip or locking mechanism for single-person operation.