Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.

Abstract: A storage system is configured to accept subsequent versions of write data on a given track to multiple respective slots of shared global memory. A track index table presents metadata at the track level, and can hold up to N slots of data. All slots of shared global memory holding data owed to the source volume and to snapshots of the source volume are bound to the track in the track index table. Each time a write occurs on a track, the track index table is used to determine when a write pending slot for the track is owed to a snapshot copy of the storage volume. When a write pending slot contains data that is owed to a snapshot copy of the source volume, a new slot is allocated to the write IO and bound to the track in the track index table.

Abstract: A control unit of a multipath data transportation system that optimizes the load of the multiple communication paths of this system when the system transmits a data segment over these paths in parallel with forward error correction. The control unit determines an optimized number of packets to send over each path based on a prediction of quality for each path. The transmitted packets include systematic packets and coded packets.

Abstract: Methods and systems are provided for generating alerts in association with a request to open an account for an individual. For example, information identifying an individual may be received from a financial entity in association with the financial entity receiving a request to open an account for the individual from a requesting entity. The requesting entity may be a vendor or service provider associated with the financial entity. An electronic notification may then be sent to the individual, which may include a selectable option to indicate that the individual does not authorize opening of the account. In response to receiving an indication that the individual does not authorize opening of the account, notifications may be sent to both the financial entity and the requesting entity indicating that the individual has not authorized opening of the account.

Abstract: Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibitor therapies using the same.

Abstract: An endoscopy system according to the present disclosure includes an adapter for coupling a mobile device to an endoscope. A guide can be included that enables proper alignment of the adapter with the mobile device so that a generally centered image is presented on the mobile device from the endoscope. Further, various embodiments of the adapter can include integrated optical lenses.

Abstract: An unmanned aerial vehicle can be configured to adjust a beam direction, provide path information, act as a base station, act as a cluster head, include an improved directional antenna or array of directional antennas, communicate in a collaboration using belief propagation, receive communications from a serving station aiding in navigation or improved signal performance, or the like.

Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.

Abstract: According to various embodiments, a medical system and method for early detection of shock may include devices configured to provide information about multiple patient parameters. In certain embodiments, the system may receive input from a regional saturation sensor. Based on these inputs, the system may provide a diagnosis of shock and/or distinguish between various types of shock.

Abstract: A removable base of a wearable medical monitor includes a mating surface configured to reversibly couple the removable base to a body of the wearable medical monitor. The removable base may also include certain functional features, such as a sensor configured to detect a physiological parameter of a patient and/or a memory configured to store data for identifying characteristics of the sensor or the patient.

Abstract: According to various embodiments, a medical system and method for early detection of shock may include devices configured to provide information about multiple patient parameters. In certain embodiments, the system may receive input from a regional saturation sensor. Based on these inputs, the system may provide a diagnosis of shock and/or distinguish between various types of shock.

Abstract: According to various embodiments, a medical system and method for early detection of shock may include devices configured to provide information about multiple patient parameters. In certain embodiments, the system may receive input from a regional saturation sensor. Based on these inputs, the system may provide a diagnosis of shock and/or distinguish between various types of shock.

Abstract: Methods, apparatuses and systems for detecting smoking behavior of a user are described. Methods may include receiving accelerometry data from at least one accelerometer coupled with the user and detecting a pattern of movement from the accelerometry data indicative of smoking behavior. Described methods may also include detecting a plurality of sub-patterns of movement such as repeatedly swinging at least one hand toward and away from the user's face in a sequence indicative of smoking behavior. An apparatus for detecting smoking behavior of a user may include a processor, memory in electronic communication with the processor, and instructions stored in the memory and operable, when executed by the processor, to cause the apparatus to receive accelerometry data from at least one accelerometer and detect a pattern of movement from the accelerometry data indicative of smoking behavior.

Abstract: A removable base of a wearable medical monitor includes a mating surface configured to reversibly couple the removable base to a body of the wearable medical monitor. The removable base may also include certain functional features, such as a sensor configured to detect a physiological parameter of a patient and/or a memory configured to store data for identifying characteristics of the sensor or the patient.

Abstract: According to various embodiments, a medical system and method for early detection of shock may include devices configured to provide information about multiple patient parameters. In certain embodiments, the system may receive input from a regional saturation sensor. Based on these inputs, the system may provide a diagnosis of shock and/or distinguish between various types of shock.

Abstract: A decoder, encoder and corresponding system are disclosed for providing fast Forward Error Correcting (FEC) decoding and encoding of syndrome-based error correcting codes. Three-parallel processing is performed by elements of the system. More particularly, in an illustrative embodiment, a decoder performs three-parallel syndrome generation and error determination and calculations, and an encoder performs three-parallel encoding. Low power and complexity techniques are used to save cost and power yet provide relatively high speed encoding and decoding.

Abstract: A decoder, encoder and corresponding system are disclosed for providing fast Forward Error Correcting (FEC) decoding and encoding of syndrome-based error correcting codes. Three-parallel processing is performed by elements of the system. More particularly, in an illustrative embodiment, a decoder performs three-parallel syndrome generation and error determination and calculations, and an encoder performs three-parallel encoding. Low power and complexity techniques are used to save cost and power yet provide relatively high speed encoding and decoding.