Abstract: The invention provides a compound of compound of formula (I): or a salt thereof, wherein R1, n, L, and X have any of the values described herein, as well as compositions and lipid nanoparticles comprising a compound of formula I, and their use for delivering therapeutic agents such as siRNA and mRNA.

Abstract: Apparatus include a first laser diode situated to emit a beam from an exit facet along an optical axis, the beam as emitted having perpendicular fast and slow axes perpendicular to the optical axis, a first fast axis collimator (FAC) optically coupled to the beam as emitted from the exit facet and configured to direct the beam along a redirected beam axis having a non-zero angle with respect to the optical axis of the first laser diode, a second laser diode situated to emit a beam from an exit facet of the second laser diode along an optical axis parallel to the optical axis of the first laser diode and with a slow axis in a common plane with the slow axis of the first laser diode, and a second fast axis collimator (FAC) optically coupled to the beam as emitted from the exit facet of the second laser diode and configured to direct the beam along a redirected beam axis having a non-zero angle with respect to the optical axis of the second laser diode.

Abstract: Methods for atomic layer deposition (ALD) or plasma enhanced atomic layer deposition (PEALD) of low-K films are described. A method of depositing a film comprises exposing a substrate to a silicon precursor having the general formulae (Ia), (Ib), (Ic), (Id), (IX), or (X); and exposing the substrate to an oxidant to react with the silicon-containing film to form one or more of a silicon oxycarbide (SiOC) film or a silicon oxycarbonitride (SiOCN) film on the substrate, the oxidant comprising one or more of a carboxylic acid, an aldehyde, a ketone, an ethenediol, an oxalic acid, a glyoxylic acid, a peroxide, an alcohol, and a glyoxal.

Abstract: An eye mask with movable speakers is provided. The eye mask has a mask main body and two speaker assemblies. The mask main body is configured to cover a user's eyes and ears and comprises two inner spaces. The two inner spaces correspond to the user's ears in location. The two speaker assemblies are mounted in the inner spaces respectively, and at least one of the speaker assemblies is capable of moving in the corresponding inner space. When wearing the present eye mask, the user may cover eyes first and then connect and tie two ends of the mask main body, thereby securing the eye mask on the head. In the meantime, the mask also covers the user's ears. Then, the two speaker assemblies may be moved in the inner spaces to align with the user's ears respectively.

Abstract: A substrate processing system includes an upper chamber and a gas delivery system to supply a gas mixture to the upper chamber. An RF generator generates plasma in the upper chamber. A lower chamber includes a substrate support. A dual ion filter is arranged between the upper chamber and the lower chamber. The dual ion filter includes an upper filter including a first plurality of through holes configured to filter ions. A lower filter includes a second plurality of through holes configured to control plasma uniformity.

Abstract: A system and method of vibration and audible noise reduction in a LiDAR resonator includes a spring fork mechanism including multiple spring forks. Each spring fork includes two tines. The first tine of a first and second spring fork include a mounted optical module to transmit a light pulse and receive a reflection of the light pulse. The second tine of the first and second spring forks include a mounted counterweight having a mass and center of gravity equal to a mass and center of gravity of the mounted optical module. To reduce or eliminate longitudinal vibrations each tine includes a first section and a second section, the first section attached to the second section by a U-shaped section.

Abstract: An approach for facilitating mechanical and electrical connection of electric machines and electrical components in an electrical system using connectors with quick connect/disconnect electrical connectors is disclosed. Each quick connect/disconnect electrical connector can be placed on the end of an electrical power distribution cable that connects with an electric machine or electrical component. The electric machines and electrical components and the electrical power distribution cables can have hollow coolant passages formed therein to receive cooling fluid from a cooling device for direct cooling of the electric machines, electrical components and the electrical power distribution cables.

Abstract: A multi-piece eye mask is provided and has a first headband, a second headband, and two speaker assemblies. The first headband is configured to cover the user's eyes and ears. The second headband is detachably mounted on the first headband. The speaker assemblies are mounted in the second headband and corresponding to the user's ears in location. The first headband can be separated from the second headband, which contains the eye cups, and the first headband with the eye cups is independently washable.

Abstract: Methods and systems for imaging a target. In some examples, a system includes an optical modulator configured for applying, at each time of an exposure window, a respective optical modulation pattern to a received image of the target to output a modulated image. The system includes a camera configured for capturing a single image frame for the exposure window by receiving, at each of time, the modulated image of the target. The system includes a demodulator implemented on a computer system and configured for demodulating the single image frame based on the optical modulation patterns to recover a number of recovered image frames each depicting the target at a respective recovered time within the exposure window.

Abstract: A method is disclosed for treating an anodized metal surface. According to the method, polynuclear clusters comprising aluminum oxide hydroxide are applied to the anodized metal surface.

Abstract: A virtualization platform for Network Functions Virtualization (NFV) is provided. The virtualization platform may include a host processor coupled to an acceleration coprocessor. The acceleration coprocessor may be a reconfigurable integrated circuit to help provide improved flexibility and agility for the NFV. The coprocessor may include multiple virtual function hardware acceleration modules each of which is configured to perform a respective accelerator function. A virtual machine running on the host processor may wish to perform multiple accelerator functions in succession at the coprocessor on a given data. In one suitable arrangement, intermediate data output by each of the accelerator functions may be fed back to the host processor. In another suitable arrangement, the successive function calls may be chained together so that only the final resulting data is fed back to the host processor.

Abstract: The present disclosure generally provides compounds that antagonize certain T2R taste receptors, including related uses, methods, and compositions for the reduction of bitter taste and/or the enhancement of sweet taste. In certain aspects, the disclosure provides flavored articles or flavored compositions comprising such compounds, as well as uses of such compounds to reduce the bitter taste and/or enhance the sweet taste of such flavored articles or flavored compositions.

Abstract: The general problem of pattern change discovery between high-dimensional data sets is addressed by considering the notion of the principal angles between the subspaces is introduced to measure the subspace difference between two high-dimensional data sets. Current methods either mainly focus on magnitude change detection of low-dimensional data sets or are under supervised frameworks. Principal angles bear a property to isolate subspace change from the magnitude change. To address the challenge of directly computing the principal angles, matrix factorization is used to serve as a statistical framework and develop the principle of the dominant subspace mapping to transfer the principal angle based detection to a matrix factorization problem. Matrix factorization can be naturally embedded into the likelihood ratio test based on the linear models. The method may be unsupervised and addresses the statistical significance of the pattern changes between high-dimensional data sets.

Abstract: Systems and methods are described for generating record clusters. The methods comprise receiving a plurality of records from data sources and providing at least a subset of the records to a scoring model that determines scores for various pairings of the records, a score for a given pair of the records representing a probability that the given pair of records contain data elements about the same entity. The method further comprises generating a graph data structure that includes a plurality of nodes, individual nodes representing a different record from the records. The method also comprises assigning a different unique identifier to individual clusters of the final clusters and responding to a request for data regarding a given entity by providing aggregated data elements from those records of the records associated with a cluster of the final clusters having an identifier that represents the given entity.

Abstract: A housing of a device comprises a screw boss that extends outwardly from a first base plate proximate to a corner of the housing. Additionally, the housing of the device includes a force dissipation member. The force dissipation member includes a central portion that is sized to detachably attach around the screw boss. The force dissipation member further includes at least two arms that extend outwardly from the central portion, wherein each arm of the at least two arms is attached to a different side of the two walls of the housing.

Abstract: The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aß plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.

Abstract: According to an example, a structure is generally described. The structure may include an inductor core having a plurality of surfaces; and at least one conductor integrated with at least one surface of the plurality of surfaces of the inductor core.

Abstract: Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

Abstract: A blade for a measuring tape device may include a first end at which an end hook is configurable, a second end configured to be operably coupled to a reel assembly, a first portion of a metallic strip of material extending between the first end and a transition region, and a second portion of the metallic strip of material extending between the transition region and the second end. A width of the metallic strip of material in the first portion may be less than a width of the metallic strip of material in the second portion.