Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.

Abstract: Various embodiments provide for a filter assembly. The filter assembly includes a filter housing, a filter element, and a cover. The filter housing has a first housing end and a second housing end that define an internal cavity. The filter housing has a housing seal member formed on the second housing end. The filter element is disposed in the internal cavity. The filter element includes a filter media, an endplate, and a filter seal member. The filter media has a first media end and a second media end. The endplate is disposed at the first media end. The filter seal member is formed on the endplate. The filter seal member includes an inner seal portion and an outer seal portion. The filter seal member is configured to engage the housing seal member. The cover secures the engagement of the housing seal member and the filter seal member.

Abstract: A laundry care or dish care composition can include a poly alpha-1,6-glucan derivative, wherein the poly alpha-1,6-glucan derivative includes: (i) a poly alpha-1,6-glucan backbone of glucose monomer units, wherein greater than or equal to 40% of the glucose monomer units are linked via alpha-1,6 glycosidic linkages, and wherein from 0% to less than 30% of the glucose monomer units are linked via alpha-1,3 glycosidic linkages, and optionally at least 5% of the backbone glucose monomer units have branches via alpha-1,2 and/or alpha-1,3 glycosidic linkages; and (ii) at least one organic group linked to the poly alpha-1,6-glucan backbone through a linkage moiety; wherein, the poly alpha-1,6-glucan backbone has a weight average degree of polymerization of at least 5; and wherein, the poly alpha-1,6-glucan derivative has a degree of substitution of linkage moiety of from 0.20 to 1.00.

Abstract: The present invention comprises conjugates comprising a glucagon-like peptide 1 (GLP-1) fusion peptide coupled to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

Abstract: Disclosed herein is a method and a data processing system for environment evaluation, and a computer-readable storage medium with a computer program for executing the aforementioned method stored thereon. A data processing system according to one aspect comprises: at least one processor; at least one memory; and a computer program stored on the memory and executable on the processor, wherein execution of the computer program on the processor results in the following operations: obtaining user evaluations of an environment and environmental parameter measurements from a plurality of mobile devices; and generating evaluation information about the environment from the user evaluations and the environmental parameter measurements.

Abstract: Provided are methods for managing texture data. The methods include preloading a first plurality of texture descriptor values from a memory location in a first buffer located in a first logic block, wherein the first buffer is further configured to receive data corresponding to non-texture functions performed in the first logic block and preloading the first plurality of texture descriptor values from a memory location into a second buffer in a second logic block if the first buffer is full. The methods further include utilizing the first plurality of texture descriptor values, within the second logic block, to perform a shader calculation, and loading, dynamically, a second plurality of texture descriptor values from memory into the first buffer, wherein the first logic block requires additional data. Additionally, the methods can include writing, if the first buffer is full, the second plurality of texture descriptor values over a portion of the first plurality of texture descriptor values.

Abstract: Provided are methods for managing texture data in Graphics Processing Units (GPUs). The methods include receiving, into an arbiter, a preload request configured to request processing of texture data in advance of shader processing and receiving, into the arbiter, a dependent read request configured to request processing of texture data after shader processing. The methods also include receiving, into the arbiter, a capacity signal from a texture buffer and determining, utilizing the virtual buffer capacity signal, a selected request corresponding which of the preload request and the dependent read request is granted. The methods further include processing, in a texture processor, texture data corresponding to the selected request.

Abstract: Provided are methods for managing texture data. The methods include preloading a first plurality of texture descriptor values from a memory location in a first buffer located in a first logic block, wherein the first buffer is further configured to receive data corresponding to non-texture functions performed in the first logic block and preloading the first plurality of texture descriptor values from a memory location into a second buffer in a second logic block if the first buffer is full. The methods further include utilizing the first plurality of texture descriptor values, within the second logic block, to perform a shader calculation, and loading, dynamically, a second plurality of texture descriptor values from memory into the first buffer, wherein the first logic block requires additional data. Additionally, the methods can include writing, if the first buffer is full, the second plurality of texture descriptor values over a portion of the first plurality of texture descriptor values.

Abstract: Provided are methods for managing texture data in Graphics Processing Units (GPUs). The methods include receiving, into an arbiter, a preload request configured to request processing of texture data in advance of shader processing and receiving, into the arbiter, a dependent read request configured to request processing of texture data after shader processing. The methods also include receiving, into the arbiter, a capacity signal from a texture buffer and determining, utilizing the virtual buffer capacity signal, a selected request corresponding which of the preload request and the dependent read request is granted. The methods further include processing, in a texture processor, texture data corresponding to the selected request.