Abstract: The present invention relates to a method for manufacturing coated paperboard suitable for packaging paperboard applications. The method comprises coating a first surface of the paperboard web by applying a) a first coating composition in a precoating unit for forming a precoating layer comprising inorganic mineral pigment particles and least one binder for sealing the first surface of the paperboard web; and b) a second coating composition in a curtain coating unit for forming at least one barrier coating layer on the first surface of the paperboard web; and c) a third coating composition comprising a polymer dispersion in the curtain coating unit for forming at least one heat sealable coating layer on the first surface of the paperboard web. The temperature of the coated paperboard web is controlled and adjusted, and the paperboard web is cooled in at least one cooling unit.

Abstract: The present invention relates to a method for manufacturing coated paperboard suitable for packaging paperboard applications. The method comprises coating a first surface of the paperboard web by applying a) a first coating composition in a precoating unit for forming a precoating layer comprising inorganic mineral pigment particles and least one binder for sealing the first surface of the paperboard web; and b) a second coating composition in a curtain coating unit for forming at least one barrier coating layer on the first surface of the paperboard web; and c) a third coating composition comprising a polymer dispersion in the curtain coating unit for forming at least one heat sealable coating layer on the first surface of the paperboard web. The temperature of the coated paperboard web is controlled and adjusted, and the paperboard web is cooled in at least one cooling unit.

Abstract: A wet end of a paper or board machine has at least one vertical, self-supporting installation module (10a, 10b) to be positioned into connection with the machine which module is supported from its lower end by foundation structures of the machine construction and which extends at least to the height of a second maintenance platform (50b) of the machine, which installation module (10) includes at least valves (40) and pipes (30) related to the hydraulic and/or pneumatic actuators of the machine.

Abstract: A wet end of the machine comprises at least one vertical, self-supporting installation module (10a, 10b) to be positioned into connection with the machine which module is supported from its lower end by foundation structures of the machine construction and which extends at least to the height of a second maintenance platform (50b) of the machine, which installation module (10) includes at least valves (40) and pipes (30) related to the hydraulic and/or pneumatic actuators of the machine.

Abstract: A method for manufacturing a web of paper and paperboard, in which method a spray-coating technique is used for applying a web treatment substance to at least one surface of a moving web. The qualities of the web treatment substance are selected such that at least the droplet size and viscosity of the web treatment substance are controlled such as to make the thickness of the applied web treatment substance essentially equal in at least two randomly selected sample areas. According to the invention, the applied coating conforms with the surface contour of the base sheet. A paper manufactured using the method.

Abstract: A method and apparatus for assaying a drug candidate with a biosensor having one or more sensing surface-bound biomolecules associated therewith are disclosed. The method comprises the steps of measuring the binding interaction between the drug candidate and the one or more sensing surface-bound biomolecules of the biosensor to obtain an estimate of at least one binding interaction parameter of the drug candidate, and then comparing the estimated binding interaction parameter against a mathematical expression correlated from binding interaction data associated with known drug compounds to determine an estimate of at least pharmacokinetic parameter of absorption, distribution, metabolism, or excretion (ADME) that is related to the drug candidate. The present invention allows for the simultaneous measurement of different pharmacokinetic parameters of the drug candidate, as well as an indication of the drug candidate's solubility, by use of a single analytical instrument.

Abstract: Surface regeneration of affinity biosensors and characterization of biomolecules associated therewith by multivariate technique employing cocktails of regeneration agents to optimize regeneration of biosensor surface and/or characterize biomolecules associated therewith. Kits and stock solutions for use in the context of this invention, as well as associated computer algorithms are also disclosed.