Abstract: An isolated protein which is structurally and functionally similar to avidin but with improved properties, such as better affinity towards biotin conjugate, useful immunological properties or faster biotin dissociation rate, compared to avidin and streptavidin.

Abstract: The subject invention pertains to a transmembrane protein capable of binding to biotinylated molecules, the protein comprising a cytoplasmic domain, a membrane-spanning domain and an extracellular domain, wherein the extracellular domain comprises biotin-binding activity, and methods of use. The protein can be expressed in a cell, thereby targeting a biotinylated drug.

Abstract: The present invention pertains to a novel transmembrane protein capable of binding to biotinylated molecules, the protein comprising a cytoplasmic domain, a membrane-spanning domain and an extracellular domain, wherein the extracellular domain comprises biotin-binding activity.

Abstract: The present invention relates to new mutants of biotin binding proteins with improved properties, e.g., thermally stabilized compared to wild type proteins. Proteins, which bind biotin include chicken avidin and bacterial streptavidin, other poultry avidins, such as avidin proteins isolated from the duck, goose, ostrich and turkey, and chicken avidin-related proteins (AVRs).

Abstract: The present invention relates to new chimeric mutants of avidin protein with improved properties, e.g. thermostability, better stability against proteolysis, better charge properties (for example lower pl) compared to native avidin and avidin-related proteins, AVRs. The chimeric avidin mutants comprise mutants where a region or regions in avidin are substituted by a corresponding region or regions from an AVR protein.

Abstract: The present invention pertains to a novel transmembrane protein capable of binding to biotinylated molecules, the protein comprising a cytoplasmic domain, a membrane-spanning domain and an extracellular domain, wherein the extracellular domain comprises biotin-binding activity.

Abstract: The present invention relates to immunochemical analysis methods, which are useful in the detection of natural rubber latex allergens or specific antibodies against them. Specifically, the present invention relates to immunochemical analysis methods, which are useful in the detection the possible residual content of allergenic proteins or peptides derived from natural rubber latex in a finished product made of or containing natural rubber latex. Additionally, the present invention relates to immunochemical analysis methods, specifically, in the in vitro detection and analysis of specific immunoglobulin E (IgE) and/or G4 (IgG4) antibodies against latex allegens in a patient suspected of suffering from latex allergy and in in vivo diagnosis of latex allergy. The present invention further relates to preparations and specific immunochemical test kits useful in such methods.