Patents by Inventor Markku Linnoila

Markku Linnoila has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Allelic variation of the serotonin 5HT7 receptor
    Patent number: 5763183
    Abstract: An allelic variant of the 5HT7 serotonin receptor was discovered. Family study data indicate that this variant can be correlated to alchoholic offerders. DNA encoding the variant protein, the protein itself, vectors containing the variant gene and cell lines carrying a vector with the variant gene are part of the invention.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: June 9, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ullamari Pesonen, Markku Koulu, Markku Linnoila, David Goldman, Matti Virkkunen
  • Allelic variation of the serotonin 5HT.sub.2c receptor
    Patent number: 5654139
    Abstract: We describe identification of a non-conservative amino acid substitution in the 5-HT.sub.2C receptor gene. The variant was found using single strand conformational polymorphism (SSCP) analysis. By typing this polymorphism in CEPH families, the gene was genetically mapped on the long arm of the X chromosome. Since this polymorphism was not detectable as a conventional RFLP, we also developed a PCR-RFLP based method which allows rapid genotyping in populations and families.
    Type: Grant
    Filed: September 21, 1994
    Date of Patent: August 5, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jaakko Lappalainen, Markku Linnoila, David Goldman
  • Method for detecting abnormal serotonergic function
    Patent number: 5589331
    Abstract: A method of detecting abnormal serotonergic function in an impulsive human subject is disclosed. The method comprises detecting an L allele of a gene encoding tryptophan hydroxylase. The invention also includes an isolated nucleic acid having a sequence specific to an L allele of a gene encoding tryptophan hydroxylase. The nucleic acid may migrate in a denaturing gel at the same rate as a second nucleic acid specific to a corresponding region of a U allele of a gene encoding tryptophan hydroxylase, and migrate in a nondenaturing gel at a rate about 1.02 times the migration rate of the second nucleic acid.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: December 31, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: David A. Nielsen, David Goldman, Markku Linnoila, Matti Virkkunen
  • Attenuation of ethyl alcohol intoxication with alpha-2 adrenoceptor antagonists
    Patent number: 5109007
    Abstract: A method is provided for attenuating the intoxicating effects of ethyl alcohol in a patient, by administering to a patient in need thereof, an alpha-2 adrenoceptor antagonist compound. Two preferred compounds useful in the present invention, each being a highly potent and selective alpha-2 adrenoceptor antagonist, are atipamezole and idazoxan.
    Type: Grant
    Filed: May 10, 1990
    Date of Patent: April 28, 1992
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Markku Linnoila, Richard G. Lister, Michael J. Durcan
  • Attenuation of ethyl alcohol intoxication with alpha-2 adrenoceptor antagonists
    Patent number: 4968692
    Abstract: A method is provided for attenuating the intoxicating effects of ethyl alcohol in a patient, by administering to a patient in need thereof, an alpha-2 adrenoceptor antagonist compound. Two preferred compounds useful in the present invention, each being a highly potent and selective alpha-2 adrenoceptor antagonist, are atipamezole and idazoxan.
    Type: Grant
    Filed: January 6, 1989
    Date of Patent: November 6, 1990
    Assignee: The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services
    Inventors: Markku Linnoila, Richard G. Lister, Michael J. Durcan