Patents by Inventor Marko Z. Radic

Marko Z. Radic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for inhibiting inflammation
    Patent number: 11202850
    Abstract: As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4).
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: December 21, 2021
    Assignees: The University of Memphis Research Foundation, The University of Tennessee Research Foundation
    Inventors: Gary L. Bowlin, Allison E. Fetz, Marko Z. Radic
  • METHODS OF USING CYTOTOXIC T CELLS FOR TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20200085871
    Abstract: The present disclosure relates to methods of using engineered cytotoxic T cells comprising a recombinant vector construct that expresses a chimeric antigen receptor to reduce and/or deplete the number of B cells in a subject in order to treat autoimmune diseases, such as lupus.
    Type: Application
    Filed: March 19, 2018
    Publication date: March 19, 2020
    Inventor: Marko Z. RADIC
  • COMPOSITIONS AND METHODS FOR INHIBITING INFLAMMATION
    Publication number: 20190275200
    Abstract: As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4).
    Type: Application
    Filed: March 11, 2019
    Publication date: September 12, 2019
    Applicant: THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: GARY L. BOWLIN, ALLISON E. FETZ, MARKO Z. RADIC
  • Recombinant antibody fusion proteins and methods for detection of apoptotic cells
    Publication number: 20030138419
    Abstract: Recombinant antibody single chain variable fragments (scFv) useful for detecting apoptotic cells are disclosed. The antibodies selectively bind on the surface of apoptotic cells. Methods of generating and employing the antibodies are also provided. Methods of detecting modulation of apoptosis are disclosed. Methods of evaluating the efficacy of a candidate therapeutic compound adapted to effect a change in apoptosis are also disclosed. Additionally, a kit for the detection of apoptotic cells is also disclosed.
    Type: Application
    Filed: November 15, 2002
    Publication date: July 24, 2003
    Applicant: The University of Tennessee Research Corporation
    Inventors: Marko Z. Radic, Brian A. Cocca