Patents by Inventor Markus Frank

Markus Frank has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150201623
    Abstract: The present invention relates to a method for increasing the vigor and/or crop yield of agricultural plants under essentially non-existent pathogen pressure, wherein the plants, the plant propagules, the seed of the plants and/or a locus where the plants are growing or are intended to grow are treated with an effective amount of a composition comprising a Bacillus subtilis strain with NRRL Accession No. B-21661, a mutant of the strain having all the identifying characteristics of the strain, or a cell-free extract thereof; and a compound selected from the group consisting of fosetyl, fosetyl-aluminum, propamocarb, and propamocarb hydrochloride; wherein the vigor and/or crop yield of agricultural plants under essentially non-existent pathogen pressure is increased.
    Type: Application
    Filed: March 18, 2015
    Publication date: July 23, 2015
    Inventors: Markus FRANK, David Ernest SILVA
  • Patent number: 9051289
    Abstract: The present invention relates to compounds of formula I wherein RS denotes F or CF3, Ra denotes H or C1-4-alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: June 9, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Georg Dahmann, Holger Wagner, Matthias Eckhardt, Markus Frank, Marco Santagostino, Juergen Schnaubelt, Uwe Stertz, Thorsten Pachur
  • Publication number: 20150130289
    Abstract: An adaptive near field electromagnetic coupler for coupling electromagnetic power to a plane metallic trace (inlay) independently of the inlay geometry and/or orientation without external control algorithms. This is achieved by employing a microstructure of phase altering elements suitable for creating a constant phase field distribution along a top surface of the coupler structure. This is advantageously applicable to printing devices having a function of encoding RFID layers printed on a medium. In view of the provided flexibility, the coupler arrangement can be employed in a variety of printers of different mechanical design.
    Type: Application
    Filed: May 22, 2013
    Publication date: May 14, 2015
    Inventors: Mats Hedberg, Markus Frank
  • Publication number: 20150112062
    Abstract: The present invention relates to substituted quinazolines of formula (I) wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Application
    Filed: December 23, 2014
    Publication date: April 23, 2015
    Inventors: Waldemar PFRENGLE, Markus FRANK, Thomas KLEIN
  • Publication number: 20150105371
    Abstract: This invention relates to co-crystals and salts of CCR3 inhibitors of formula 1, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases related with the CCR3-receptor.
    Type: Application
    Filed: December 17, 2014
    Publication date: April 16, 2015
    Inventors: Markus FRANK, Hans HAEBERLE, Manuel HENRY, Thorsten PACHUR, Marco SANTAGOSTINO, Uwe STERTZ, Thomas TREBING, Ulrike WERTHMANN
  • Publication number: 20150087829
    Abstract: The present invention relates to compounds of formula I wherein RS denotes F or CF3, Ra denotes H or C1-4-alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.
    Type: Application
    Filed: September 24, 2014
    Publication date: March 26, 2015
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Georg DAHMANN, Holger WAGNER, Matthias ECKHARDT, Markus FRANK, Marco SANTAGOSTINO, Juergen SCHNAUBELT, Uwe STERTZ, Thorsten PACHUR
  • Patent number: 8962636
    Abstract: The present invention relates to substituted quinazolines of formula (I) wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV(DPP-IV).
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: February 24, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Waldemar Pfrengle, Markus Frank, Thomas Klein
  • Patent number: 8883800
    Abstract: The present invention relates to substituted quinazolines of formula (I): wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: November 11, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Waldemar Pfrengle, Markus Frank, Thomas Klein
  • Patent number: 8859758
    Abstract: The present invention relates to a process for producing a water-absorbent polysaccharide including the process steps of bringing into contact an uncrosslinked polysaccharide with a polyphosphate or a polyphosphoric acid as crosslinking agent in the presence of water to form a polysaccharide gel and crosslinking the polysaccharide gel. The invention further relates to a water-absorbent polysaccharide obtainable by this process, a water-absorbent polysaccharide, a composite, a process for producing a composite, a composite produced by this process, the use of the water-absorbent polysaccharides or of the composites as well as the use of polyphosphates.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: October 14, 2014
    Assignee: Evonik Degussa GmbH
    Inventors: Markus Frank, Frank Loeker, Dirk Magolei, Scott J. Smith
  • Publication number: 20140228283
    Abstract: The present invention relates to substituted quinazolines of formula (I) wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-W (DPP-IV).
    Type: Application
    Filed: July 13, 2012
    Publication date: August 14, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Waldemar Pfrengle, Markus Frank, Thomas Klein
  • Patent number: 8742115
    Abstract: This invention relates to co-crystals and salts of CCR3 inhibitors of formula 1, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases related with the CCR3-receptor.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: June 3, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Markus Frank, Hans Haeberle, Manuel Henry, Thorsten Pachur, Marco Santagostino, Uwe Stertz, Thomas Trebing, Ulrike Werthmann
  • Publication number: 20140135307
    Abstract: This invention relates to co-crystals and salts of CCR3 inhibitors of formula 1, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases related with the CCR3-receptor.
    Type: Application
    Filed: January 22, 2014
    Publication date: May 15, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Markus FRANK, Hans HAEBERLE, Manuel HENRY, Thorsten PACHUR, Marco SANTAGOSTINO, Uwe STERTZ, Thomas TREBING, Ulrike WERTHMANN
  • Patent number: 8645895
    Abstract: A system and a method for testing the ESD behavior, wherein a circuit (7) is automatically tested at circuit diagram level in that technology-specific ESD data is provided in database (2) for each circuit component present in the circuit, without requiring complex circuit simulations, for example based on front end or back end data, by taking into account the layout.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: February 4, 2014
    Assignee: X-Fab Semiconductor Foundries AG
    Inventors: Lars Bergmann, Angela Konrad, Markus Frank
  • Publication number: 20140018532
    Abstract: The present invention relates to a process for producing a water-absorbent polysaccharide including the process steps of bringing into contact an uncrosslinked polysaccharide with a polyphosphate or a polyphosphoric acid as crosslinking agent in the presence of water to form a polysaccharide gel and crosslinking the polysaccharide gel. The invention further relates to a water-absorbent polysaccharide obtainable by this process, a water-absorbent polysaccharide, a composite, a process for producing a composite, a composite produced by this process, the use of the water-absorbent polysaccharides or of the composites as well as the use of polyphosphates.
    Type: Application
    Filed: September 12, 2013
    Publication date: January 16, 2014
    Applicant: EVONIK DEGUSSA GMBH
    Inventors: Markus Frank, Frank Loeker, Dirk Paepen, Scott J. Smith
  • Patent number: 8592652
    Abstract: The invention relates to a method of generating or increasing a pathogen resistance in plants by reducing the expression of at least one subtilisin polypeptide or a functional equivalent thereof. The invention relates to novel nucleic acid sequences coding for a Hordeum vulgare subtilisin (HvRNR9) and Triticum aestivum subtilisin (TaRNR9) polynucleotide and describes homologous sequences (RNR9) thereof, and to their use in methods for obtaining a pathogen resistance in plants, and to nucleic acid constructs, expression cassettes and vectors which comprise these sequences and which are suitable for mediating a fungal resistance in plants. The invention furthermore relates to transgenic organisms, in particular plants, which are transformed with these expression cassettes or vectors, and to cultures, parts or transgenic propagation material derived therefrom.
    Type: Grant
    Filed: January 15, 2008
    Date of Patent: November 26, 2013
    Assignee: BASF Plant Science GmbH
    Inventors: Markus Frank, Patrick Schweizer, Dimitar Douchkov
  • Patent number: 8580953
    Abstract: The present invention relates to a process for producing a water-absorbent polysaccharide including the process steps of bringing into contact an uncrosslinked polysaccharide with a polyphosphate or a polyphosphoric acid as crosslinking agent in the presence of water to form a polysaccharide gel and crosslinking the polysaccharide gel. The invention further relates to a water-absorbent polysaccharide obtainable by this process, a water-absorbent polysaccharide, a composite, a process for producing a composite, a composite produced by this process, the use of the water-absorbent polysaccharides or of the composites as well as the use of polyphosphates.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: November 12, 2013
    Assignee: Evonik Degussa GmbH
    Inventors: Markus Frank, Frank Loeker, Dirk Paepen, Scott Smith
  • Publication number: 20130184204
    Abstract: The present invention relates to substituted quinazolines of formula (I): wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Application
    Filed: July 13, 2012
    Publication date: July 18, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Waldemar PFRENGLE, Markus FRANK, Thomas KLEIN
  • Patent number: 8466228
    Abstract: The invention relates to absorptive, crosslinked polymers which are based on partly neutralized, monoethylenically unsaturated monomers carrying acid groups, and have improved properties, in particular in respect of their capacity for transportation of liquids in the swollen state, and which has a high gel bed permeability and high centrifuge retention capacity.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: June 18, 2013
    Assignee: Evonik Corporation
    Inventors: Scott J. Smith, Mark C. Joy, Whei-Neen Hsu, Markus Frank, Michael M. Azad
  • Patent number: 8373022
    Abstract: The present invention relates to methods of generating or increasing resistance to at least one biotrophic pathogen in a plant or a part of a plant by increasing the protein quantity or function of at least one Bax Inhibitor-1 (BI-1) protein in at least one part of the plant. Moreover, the invention relates to polypeptide sequences and nucleic acid sequences which code for a BI-1 protein, and to expression cassettes, vectors and organisms which comprise such sequences or such a protein.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: February 12, 2013
    Assignee: BASF Plant Science GmbH
    Inventors: Holger Schultheiβ, Markus Frank, Caroline Höfle
  • Patent number: 8367774
    Abstract: Among other things, a process for producing an agglomerated superabsorbent polymer particle and an agglomerated superabsorbent polymer particle are disclosed. The process comprises the steps of: (A) bringing superabsorbent polymer fine particles having at least about 40 wt. %, a particle size of less than about 150 ?m into contact with a fluid comprising to more than about 10 wt. % a cross-linkable, uncrosslinked polymer based on polymerized, ethylenically unsaturated, acid group-bearing monomers or salts thereof; and (B) cross-linking the uncrosslinked polymer by heating the superabsorbent polymer fine particles and the fluid to a temperature from about 20 to about 300° C., so that the cross-linkable, uncrosslinked polymer at least partially crosslinks.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: February 5, 2013
    Assignee: Evonik Stockhausen GmbH
    Inventor: Markus Frank