Abstract: The present application relates to a novel and efficient process with high yield for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate of the formula (I) in the crystalline form of modification I, wherein the x-ray diffractogram of the compound of the formula (I) in modification exhibits peak maxima of the 2 theta angle at 5.9, 6.9, 22.7, in very high purity which is significantly more cost-effective than the process known from the art and can be performed in customary pilot- and production plant-equipment (stirred tank/devices for isolation).

Abstract: The present invention relates to stable nanosuspensions of methyl {4,6-diamino-2-[5-fluoro-1-(2- fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate (Vericiguat, compound of formula (I)), processes for preparing the stable nanosuspensions, nanoparticles comprising the compound of formula (I), and pharmaceutical compositions in solid form made from the nanosuspensions.

Abstract: Quinolonecarboxylic esters of the general formula (II) are hydrolyzed to quinolonecarboxylic acids of the general formula (I): The method comprises the step A): A) reacting compounds of the formula (II) with a mixture comprising acetic acid, sulfuric acid and water In step A), ?30 to ?40 mol of acetic acid, ?0.3 to ?1 mol of sulfuric acid and ?0.9 to ?2.5 mol of water are used per mole of compounds of the formula (II). The method is particularly suitable for the synthesis of the intermediate (I) in the synthesis of pradofloxacin.

Abstract: The present invention relates to methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate in the form of a novel active compound product having improved properties, for example in respect of the isolability of the active compound product, the dischargeability of the active compound product after isolation and drying and also conveyability, sieveability and micronizability of the active compound product, and to processes for the production and formulation thereof.

Abstract: Quinolonecarboxylic esters of the general formula (II) are hydrolyzed to quinolonecarboxylic acids of the general formula (I): The method comprises the step A): A) reacting compounds of the formula (II) with a mixture comprising acetic acid, sulfuric acid and water In step A), ?30 to ?40 mol of acetic acid, ?0.3 to ?1 mol of sulfuric acid and ?0.9 to ?2.5 mol of water are used per mole of compounds of the formula (II). The method is particularly suitable for the synthesis of the intermediate (I) in the synthesis of pradofloxacin.

Abstract: The invention relates to a deviation ring for paste comprising an annular rebound wall (2) for a self-distributing centrifuge (1). The invention also relates to a corresponding self-distributing centrifuge (1). In the deviation ring, the angle of incidence ? of the tangents of the rebound wall (2) of the deviation ring (4), opposite the distribution slit (3) of the centrifuge (1), in relation to the horizontal, is between 3 and 60° over the entire opening width of the distribution slit (3).

Abstract: Method for separating blood plasma particles from a blood plasma suspension in a self-discharging centrifuge having two or more discharge slits and axially stacked baffle plates, in which the blood plasma particles are separated from the liquid phase by centrifuging and removal of the liquid phase, suctioning off liquid remaining in the drum after separation of the blood plasma particles and discharging the sediment of solid blood plasma particles from the drum by centrifugal force into a collecting container underneath the drum, the drum and the blood plasma sediment being cooled during one or more of the process steps.

Abstract: Method for the separation of blood plasma particles from the fluid phase of a blood plasma suspension using a self-discharging centrifuge, the drum of which is provided with axially stacked baffle plates.

Abstract: The invention relates to a deviation ring for paste comprising an annular rebound wall (2) for a self-distributing centrifuge (1). The invention also relates to a corresponding self-distributing centrifuge (1). In the deviation ring, the angle of incidence ? of the tangents of the rebound wall (2) of the deviation ring (4), opposite the distribution slit (3) of the centrifuge (1), in relation to the horizontal, is between 3 and 60° over the entire opening width of the distribution slit (3).