Patents by Inventor Markus Lorenz
Markus Lorenz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240124581Abstract: The present invention relates to novel anti-PD1 and anti-LAG3 antibody molecules. The invention also relates to nucleic acids encoding such antibody molecules; to methods for preparing such antibody molecules; to host cells expressing or capable of expressing such antibody molecules; to compositions comprising such antibody molecules; and to uses of such antibody molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.Type: ApplicationFiled: September 1, 2023Publication date: April 18, 2024Inventors: Markus ZETTL, Ivo LORENZ, Otmar SCHAAF, Melanie WURM, Jean-Francois FORTIN, Scott Ronald BRODEUR, Keith A. CANADA, Lukasz CHLEWICKI, Walter Carroll DAVIDSON, Pankaj GUPTA, Priyanka GUPTA, Rocío K. PÉREZ, Joseph Robert WOSKA, Jr., Haiguang XIAO, Danlin YANG
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Patent number: 11453748Abstract: An amine functional compound comprising i. least one segment consisting of at least one ether unit E and at least one ester unit, wherein the ether units and ester units are connected by an ether link or by an ester link, and wherein the sum of the number of ether units and ester units is at least three, and wherein the ether units and ester units are arranged in random order, and ii. at least one amine group ii. selected from a tertiary amine group, a salt of a tertiary amine group and a quaternary ammonium group, wherein the at least one segment is covalently linked to a polymerization starter moiety comprising the at least one amine group ii.Type: GrantFiled: August 7, 2018Date of Patent: September 27, 2022Assignee: BYK-Chemie GmbHInventors: Andreas Okkel, Irina Giebelhaus, Guillaume Wojciech Jaunky, Hans-Josef Teuwsen, Markus Lorenz, Anne Vogel, Jörg Bömer
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Publication number: 20220267523Abstract: The invention relates to a polymer or oligomer comprising a) An oligomeric or polymeric core comprising carbon atoms and at least one of oxygen atoms and nitrogen atoms, and b) at least three hydrocarbyl terminal and/or pending groups having 12 to 100 carbon atoms, wherein the hydrocarbyl groups are linked to the core via c) a linking moiety comprising i) a urethane group and ii) a group selected from urethane group, urea group, and biuret group.Type: ApplicationFiled: July 6, 2020Publication date: August 25, 2022Inventors: Andreas Okkel, Jan Von Haaren, Irina Giebelhaus, Jörg Bömer, Markus Lorenz, Peter Walter Stannek, Stacy Scranton, Jennifer Heitzer
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Publication number: 20220243011Abstract: An amine functional compound is provided comprising: i. at least one segment consisting of at least one ether unit and at least one ester unit, wherein the ether units and ester units are connected by an ether link or an ester link, and wherein the sum of the number of ether units and ester units is at least three, and wherein the ether units and ester units are arranged in random order, and ii. at least one amine group ii. selected from a tertiary amine group, a salt of a tertiary amine group and a quaternary ammonium group, and wherein each segment i. is covalently linked to the at least one amine group ii. via a linkage comprising an urethane group and another group selected from an urethane group, an urea group, a biuret group and an allophanate group.Type: ApplicationFiled: August 29, 2019Publication date: August 4, 2022Inventors: Guillaume Wojciech Jaunky, Andreas Okkel, Irina Giebelhaus, Markus Lorenz, Hans-Josef Teuwsen, Jörg Bömer, Anne Vogel
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Patent number: 11185678Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).Type: GrantFiled: December 17, 2018Date of Patent: November 30, 2021Assignees: THE CLEVELAND CLINIC FOUNDATION, FOSTER-MILLER, INC.Inventors: William A. Smith, Markus Lorenz, David Dudzinski, Hsiang Ming Chen, Peter A. Chapman, Jr., Charles J. Prisco, Nicholas G. Vitale, Stephan Weber
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Patent number: 10967120Abstract: A portable liquid drug delivery device has a reservoir part and a driving part, and the driving part has a drive that produces a torque. The reservoir part has a reservoir that retains liquid drug and an outlet port is in fluid communication with the reservoir. An engagement member has an inner thread that engages the thread of a piston rod in an engaged position and is disengaged from the thread of the piston rod in a disengaged position. The engagement member is prestressed in the disengaged position to thereby bias the engagement member toward the engaged position. The engagement member only converts the torque of the drive into a linear movement of the piston rod when the engagement member is in the engaged position. The piston is configured, upon the linear movement of the piston rod, to deliver the liquid drug to the outlet port.Type: GrantFiled: January 23, 2019Date of Patent: April 6, 2021Assignee: Roche Diabetes Care, Inc.Inventor: Markus Lorenz
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Publication number: 20200392286Abstract: The invention relates to an acid functional compound comprising i. at least one segment consisting of at least one ether unit E and at least one ester unit, wherein the ether units and ester units are connected by an ether link or by an ester link, and wherein the sum of the number of ether units and ester units is at least three, and wherein the ether units and ester units are arranged in random order, and ii. at least one acidic group which is selected from the group consisting of a phosphoric acid group, an acidic phosphoric acid ester group, a sulfonic acid group, an acidic sulfonic acid ester group and a carboxylic acid group, wherein the at least one acidic group is covalently linked to the at least one segment.Type: ApplicationFiled: August 7, 2018Publication date: December 17, 2020Inventors: Andreas Okkel, Irina Giebelhaus, Guillaume Wojciech Jaunky, Markus Lorenz
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Publication number: 20200216694Abstract: An amine functional compound comprising i. least one segment consisting of at least one ether unit E and at least one ester unit, wherein the ether units and ester units are connected by an ether link or by an ester link, and wherein the sum of the number of ether units and ester units is at least three, and wherein the ether units and ester units are arranged in random order, and ii. at least one amine group ii. selected from a tertiary amine group, a salt of a tertiary amine group and a quaternary ammonium group, wherein the at least one segment is covalently linked to a polymerization starter moiety comprising the at least one amine group ii.Type: ApplicationFiled: August 7, 2018Publication date: July 9, 2020Inventors: Andreas Okkel, Irina Giebelhaus, Guillaume Wojciech Jaunky, Hans-Josef Teuwsen, Markus Lorenz, Anne Vogel, Jörg Bömer
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Patent number: 10369260Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).Type: GrantFiled: March 6, 2015Date of Patent: August 6, 2019Assignee: The Cleveland Clinic FoundationInventors: William A. Smith, Markus Lorenz, David Dudzinski, Hsiang Ming Chen, Peter A. Chapman, Jr., Charles J. Prisco, Nicholas G. Vitale, Stephan Weber
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Publication number: 20190175824Abstract: A portable liquid drug delivery device has a reservoir part and a driving part, and the driving part has a drive that produces a torque. The reservoir part has a reservoir that retains liquid drug and an outlet port is in fluid communication with the reservoir. An engagement member has an inner thread that engages the thread of a piston rod in an engaged position and is disengaged from the thread of the piston rod in a disengaged position. The engagement member is prestressed in the disengaged position to thereby bias the engagement member toward the engaged position. The engagement member only converts the torque of the drive into a linear movement of the piston rod when the engagement member is in the engaged position. The piston is configured, upon the linear movement of the piston rod, to deliver the liquid drug to the outlet port.Type: ApplicationFiled: January 23, 2019Publication date: June 13, 2019Inventor: Markus Lorenz
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Publication number: 20190111193Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).Type: ApplicationFiled: December 17, 2018Publication date: April 18, 2019Inventors: William A. Smith, Markus Lorenz, David Dudzinski, Hsiang Ming Chen, Peter A. Chapman, JR., Charles J. Prisco, Nicholas G. Vitale, Stephan Weber
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Patent number: 9950101Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).Type: GrantFiled: May 14, 2012Date of Patent: April 24, 2018Assignee: The Cleveland Clinic FoundationInventors: William Smith, Markus Lorenz, David Dudzinski, Hsiang Ming Chen, Peter A. Chapman, Jr., Charles J. Prisco, Nicholas G. Vitale, Stephan Weber
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Publication number: 20160175503Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).Type: ApplicationFiled: March 6, 2015Publication date: June 23, 2016Inventors: William A. Smith, Markus Lorenz, David Dudzinski, Hsiang Ming Chen, Peter A. Chapman, JR., Charles J. Prisco, Nicholas G. Vitale, Stephan Weber
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Patent number: 8992407Abstract: A blood pump (26) includes a stator assembly (122) that includes a motor stator, a fluid inlet (24), and a fluid outlet (26). A rotor assembly (120) includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). A permanent magnet radial bearing (100) supports the rotor assembly for rotation about the axis (44). The radial bearing (100) includes a permanent magnet radial bearing stator (106) fixed to the stator assembly (122) and a permanent magnet radial bearing rotor (108) fixed to the rotor assembly (120). The radial bearing (100) is configured such that the radial bearing stator magnets (106) and the radial bearing rotor magnets (108) are axially offset from each other when the pump is at rest.Type: GrantFiled: May 14, 2012Date of Patent: March 31, 2015Assignee: The Cleveland Clinic FoundationInventors: William A. Smith, Markus Lorenz, David Dudzinski, Hsiang Ming Chen, Peter A. Chapman, Jr., Charles J. Prisco, Nicholas G. Vitale, Stephan Weber
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Patent number: 8347730Abstract: A substantially flexible implant holder for holding a substantially tubular implant structure during fatigue testing of the implant structure, the implant holder having a substantially elongate cavity for occupation by the tubular implant structure and a cavity-surrounding part which extends from at least a first longitudinal end of the cavity to at least a second longitudinal end of the cavity, the cavity-surrounding part having a stiffness which gradually changes from a relatively high stiffness adjacent each of the longitudinal ends of the cavity to a relatively low stiffness adjacent a middle portion which is situated between the two longitudinal ends of the cavity.Type: GrantFiled: August 14, 2007Date of Patent: January 8, 2013Assignee: C. R. Bard, Inc.Inventors: Markus Lorenz, Thiemo Blank, Roman Forreiter
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Publication number: 20120245404Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).Type: ApplicationFiled: May 14, 2012Publication date: September 27, 2012Inventors: William A. Smith, Markus Lorenz, David Dudzinski, Hsiang Ming Chen, Peter A. Chapman, JR., Charles J. Prisco, Nicholas G. Vitale, Stephan Weber
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Publication number: 20120226097Abstract: A blood pump (26) includes a stator assembly (122) that includes a motor stator, a fluid inlet (24), and a fluid outlet (26). A rotor assembly (120) includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). A permanent magnet radial bearing (100) supports the rotor assembly for rotation about the axis (44). The radial bearing (100) includes a permanent magnet radial bearing stator (106) fixed to the stator assembly (122) and a permanent magnet radial bearing rotor (108) fixed to the rotor assembly (120). The radial bearing (100) is configured such that the radial bearing stator magnets (106) and the radial bearing rotor magnets (108) are axially offset from each other when the pump is at rest.Type: ApplicationFiled: May 14, 2012Publication date: September 6, 2012Inventors: WILLIAM A. SMITH, MARKUS LORENZ, DAVID DUDZINSKI, HSIANG MING CHEN, PETER A. CHAPMAN, JR., CHARLES J. PRISCO, NICHOLAS G. VITALE, STEPHAN WEBER
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Patent number: 8196478Abstract: A fatigue test system for repetitively deforming a substantially tubular implant structure which is within a radial range and within an axial range expandable and contractable and which has at least a first and a second end, wherein the system comprises at least a first and second part which are controllably moveable relative to each other, and a first and a second fixture assembly for fixing the first end to the first part and the second end to the second part, so that the system controls in use the position of each of the first and second end of the tubular implant structure.Type: GrantFiled: August 14, 2007Date of Patent: June 12, 2012Assignee: C. R. Bard, Inc.Inventors: Markus Lorenz, Thiemo Blank, Roman Forreiter
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Patent number: 8177703Abstract: A blood pump (26) includes a stator assembly including a fluid inlet (24) and a fluid outlet (26). A rotor assembly (120) includes an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). A motor (50) imparts rotation of the impeller (40) about the axis (44). The motor (50) includes a motor stator (52) fixed to the stator assembly (122), a motor rotor (54) fixed to the rotor assembly (120), and a radial motor gap (34) between the stator (52) and the rotor (54). The pump (20) is configured to direct a mixed blood flow from the fluid inlet (24) to the fluid outlet (26) and a wash flow through the motor gap (34).Type: GrantFiled: June 6, 2006Date of Patent: May 15, 2012Assignees: The Cleveland Clinic Foundation, Foster-Miller, Inc.Inventors: William A. Smith, Markus Lorenz, David Dudzinski, Hsiang Ming Chen, Peter A. Chapman, Jr., Charles J. Prisco, Nicholas G. Vitale, Stephan Weber
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Patent number: 8098208Abstract: The invention relates to an antenna configuration, comprising at least one electrically insulating carrier substrate and at least one electrically conductive layer applied on at least one side of the carrier substrate, the electrically conductive layer having a first area region and a second area region, and the first area region of the electrically conductive layer having the form of at least one antenna structure. The at least one antenna structure is present in a manner electrically insulated from the second area region of the electrically conductive layer, and the second area region of the electrically conductive layer is subdivided, at least in regions directly adjacent to the at least one antenna structure, into island regions that are at least electrically insulated from one another. The at least one antenna configuration is suitable for use for contactlessly coupled transponders, in particular for RFID Tags or Smart Tags.Type: GrantFiled: May 26, 2007Date of Patent: January 17, 2012Assignee: PolyIC GmbH & Co. KGInventors: Jurgen Ficker, Heinrich Wild, Wolfgang Clemens, Walter Lehnberger, Markus Lorenz