Abstract: A hydraulic system for a molding machine with a hydraulic valve, includes an actuator for positioning the hydraulic valve, a machine control system realized separate from the hydraulic valve, a first signal connection between the machine control system and the hydraulic valve, and a sensor. The sensor is signal-connected to the machine control system via a second signal connection, and the machine control system is formed to carry out a valve regulation of the hydraulic valve on the basis of measured values of the sensor.

Abstract: Multi-part machine frame (12) for a, preferably percussive, forging machine, preferably a forging hammer (10), for forging workpieces, a) comprising at least two prefabricated frame parts (14, 15, 16) which are formed separately from each other, rest against each other in at least one or at least two support areas (65, 66) and are mutually supported and are pretensioned against each other with a set or adjustable pretension by means of pre-tensioning means, preferably a wire rope, and are thereby pressed onto each other in the one or more support area(s) (65, 66) and/or are connected to one another in a force-fitting manner, b) in which in the support area or at least one or each of the at least two support areas (65, 66) between two frame parts at least two pairs of abutting support surfaces (45A and 55A, 45B and 55B, 46A and 56A, 46B and 56B) are formed, which are separated by free surfaces (45C and 55C, 46D and 56D) arranged therebetween, between which an intermediate space is formed, c) wherein the suppor

Abstract: In an ex vivo method of diagnosing a disease associated with synaptic degeneration, a concentration of beta-synuclein in a cerebrospinal fluid (CSF) sample taken from a patient is determined by an enzyme-linked immunosorbent assay (ELISA).

Abstract: A hydraulic drive apparatus includes a first hydraulic pump, a drive motor connected to the first hydraulic pump, a hydraulic line system connecting the first hydraulic pump to the consumer, and a closed-loop control unit. The closed-loop control unit has a first switching element to change a displacement volume of the first hydraulic pump between a predetermined minimum value and a maximum value. A second hydraulic pump is connected to the drive motor, and the hydraulic line system connects the second hydraulic pump to a consumer and has a first branch line connected to the first hydraulic pump, a second branch line connected to a second hydraulic pump, and a main line. The two branch lines open into the main line, and the closed-loop control unit has a second switching element for changing a displacement volume of the second hydraulic pump between a predetermined minimum value and a maximum value.

Abstract: The present invention relates to method of diagnosis of diseases associated with synaptic degeneration, in particular of Creutzfeldt-Jakob-Disease or Alzheimer's Disease, and to the use of ?-synuclein as a biomarker for diagnosing or assessing the status of diseases associated with synaptic degeneration, in particular of Creutzfeldt-Jakob-Disease or Alzheimer's Disease.

Abstract: The basic invention relates, in particular, to a forging hammer, comprising an electric linear drive, having a linear rotor and a ram that is coupled to the latter for the purpose of executing forging motions, wherein the linear rotor and the ram are connected to each other through an interposed flexurally elastic decoupling structure that acts between the linear rotor and the ram, and the decoupling structure is realized and arranged to decouple the linear rotor, at least partly, from relative motions of the ram relative to the linear rotor that occur during a forging motion.

Abstract: A forming device, (e.g., a spindle press), can include a processing head, having a processing tool that is guided along a movement axis for the forming processing of a workpiece, and a processing region, located opposite the processing head, a processing station configured for the forming processing of the workpiece, and a rotary table having an axis of rotation parallel to the direction of movement and workpiece receptacles that are arranged, with respect to the axis of rotation, in an offset manner with respect to one another in the circumferential direction. The rotary table is configured such that each of the workpiece receptacles is transferable into at least one first working position located within the processing region and into at least one, second working position at least partially laterally outside a cross-sectional area of the processing head in axial projection with respect to the axis of movement.

Abstract: The present invention relates, in particular, to a forging hammer comprising a striker and a hydraulic linear drive that is coupled to the striker and is designed to drive the striker, which drive comprises a hydraulic circuit having a servo-motor hydro pump, a hydraulic cylinder, in particular a differential cylinder, which is fluidically connected downstream of the hydro pump via a directional valve module, and a servo-motor hydro generator, which is fluidically connected downstream of the hydraulic cylinder via the directional valve module, and comprising in addition a control unit configured at least for the simultaneous control of the hydro pump, the hydro generator and the directional valve module.

Abstract: The underlying invention relates in particular to a forming machine, having an electromagnetic linear motor with a linear mover and multiple coil units each with a predetermined coil pole pitch (S) which is measured in the direction of the movement axis. The linear mover includes, in an alternating arrangement along the longitudinal axis (L) thereof, first permanent magnets which are magnetized transversely to the longitudinal axis with a predetermined first magnetic pitch (T1) and second permanent magnets which are magnetized in the direction of the longitudinal axis (L) with a predetermined second magnetic pitch (T2), wherein a ratio of coil width (S) to first magnetic pitch (T1) is 3:1, and wherein a ratio of first magnetic pitch (T1) to second magnetic pitch (T2) is 2:1.

Abstract: The underlying invention relates in particular to a forming machine, having an electromagnetic linear motor with a linear mover and multiple coil units each with a predetermined coil pole pitch (S) which is measured in the direction of the movement axis. The linear mover includes, in an alternating arrangement along the longitudinal axis (L) thereof, first permanent magnets which are magnetized transversely to the longitudinal axis with a predetermined first magnetic pitch (T1) and second permanent magnets which are magnetized in the direction of the longitudinal axis (L) with a predetermined second magnetic pitch (T2), wherein a ratio of coil width (S) to first magnetic pitch (T1) is 3:1, and wherein a ratio of first magnetic pitch (T1) to second magnetic pitch (T2) is 2:1.

Abstract: A forming device, (e.g., a spindle press), can include a processing head, having a processing tool that is guided along a movement axis for the forming processing a workpiece, and a processing region, located opposite the processing head, a processing station configured for the forming processing of the workpiece, and a rotary table having an axis of rotation parallel to the direction of movement and workpiece receptacles that are arranged, with respect to the axis of rotation, in an offset manner with respect to one another in the circumferential direction. The rotary table is configured such that each of the workpiece receptacles is transferable into at least one first working position located within the processing region and into at least one, second working position at least partially laterally outside a cross-sectional area of the processing head in axial projection with respect to the axis of movement.

Abstract: The present invention relates, in particular, to a forging hammer comprising a striker and a hydraulic linear drive that is coupled to the striker and is designed to drive the striker, which drive comprises a hydraulic circuit having a servo-motor hydro pump, a hydraulic cylinder, in particular a differential cylinder, which is fluidically connected downstream of the hydro pump via a directional valve module, and a servo-motor hydro generator, which is fluidically connected downstream of the hydraulic cylinder via the directional valve module, and comprising in addition a control unit configured at least for the simultaneous control of the hydro pump, the hydro generator and the directional valve module.

Abstract: The basic invention relates, in particular, to a forging hammer, comprising an electric linear drive, having a linear rotor and a ram that is coupled to the latter for the purpose of executing forging motions, wherein the linear rotor and the ram are connected to each other through an interposed flexurally elastic decoupling structure that acts between the linear rotor and the ram, and the decoupling structure is realized and arranged to decouple the linear rotor, at least partly, from relative motions of the ram relative to the linear rotor that occur during a forging motion.

Abstract: A hydraulic device for a molding machine includes a first pump for a hydraulic fluid, a second pump for the hydraulic fluid, and a drive device for the first pump and the second pump. A first main conduit leads away from the first pump, and a second main conduit leads away from the second pump. A first consumer is connected with the first main conduit via a first opening and a first sub-conduit, and the first consumer is connected with the second main conduit via a second opening and a second sub-conduit. A second consumer is also connected with one of the main conduits via a third opening and a third sub-conduit. The second consumer is connected with the first main conduit via the third opening and the third sub-conduit, and is connected with the second main conduit via a fourth opening and a fourth sub-conduit.

Abstract: The present invention relates to a method for diagnosing a neurodegenerative disease in a subject, wherein the level of each of at least two catecholamines is measured in a sample of biological fluid from said subject.

Abstract: The present invention relates to a method for diagnosing a neurodegenerative disease in a subject, wherein the level of each of at least two catecholamines is measured in a sample of biological fluid from said subject.

Abstract: The present Invention provides a method for diagnosing and/or prognosing Parkinson's disease dementia (PDD) comprising the step of detecting O-glycosylation. in a protein comprising a Ser/Thr motive, in particular Serpin A1, and/or the level of sialic acid on a protein comprising a Ser/Thr motive, in particular Serpin A1. Further, the present invention relates to a molecule for detecting O-linked glycomoieties in a protein comprising a Ser/Thr motive, in particular Serpin A1, and/or glycosylated i so forms of a Ser/Thr motive comprising protein, in particular Serpin A1, for use in the diagnosis and/or prognosis of Parkinson's disease dementia (PDD), Furthermore, the present invention relates to means for diagnosing and/or prognosing Parkinson's disease dementia (PDD) and a kit for diagnosing and/or prognosing Parkinson's disease dementia (PDD).