Abstract: Various embodiments include a control device for setting up and/or providing a working environment with at least one performance unit to perform at least one factory task by means of machines comprising: a resource management unit programmed to request resources necessary for the working environment; and a comparison unit programmed to compare the requested resources with at least one resource agreed upon in a binding agreement stored in a distributed database and to approve the requested resource in dependence on the comparison result. The control device is programmed to set up and/or provide the working environment with at least one compared and approved resource. The at least one performance unit is programmed to coordinate the checking for complete factory task performance by one or more units involved in the working environment.

Abstract: A sensor control assembly and method providing a secured sensor data and an optimized handling of the sensor including a sensor, a first processing unit adapted to provide a cryptographic checksum of sensor data, a distributed database, a second processing unit adapted to verify the sensor data, and a third processing unit adapted to determine the demand for calibration. A manufacturing device contains at least a part of the sensor control assembly.

Abstract: A sensor data assembly providing a secured data storage for monitored data containing sensor data acquired by at least one sensor, a processing unit adapted to provide a cryptographic checksum of the monitored data and/or the sensor data acquired by the sensor, a distributed database and a first connection adapted to, at least temporarily, connect the sensor and the processing unit. A method provides manipulation proof monitored data containing sensor data of a sensor of the sensor data assembly.

Abstract: According to various examples, an operational constraint associated with an operational function—e.g., a virtual network function—implemented on a field device can be configured. According to further examples, the fulfillment of the operational constraint can be tracked. For these purposes, a distributed database is used, e.g., a blockchain.

Abstract: The method according to the invention provides for event-controlled retrieval of process data by using a publish-subscribe service, for example MQTT, and with the participation of a message broker. For the retrieval according to the invention, retrieval of a multiplicity of process data reserved in a distributed manner in the form of response messages can be carried out by a single request message. Advantageously, it permits the method according to the invention to implement a dynamic data request, in which new response messages to a request message are transmitted when changes in the process data provided or stored result. A data retrieval component transmitting the request message needs neither details about the request modalities of data-providing components nor knowledge or direct references to currently available data-providing components.

Abstract: A method for aligning an armature shaft, wherein in a first step a concentricity error of the armature shaft is determined in the region of the shaft portion by measuring a radial deflection of the armature shaft, and wherein in a second step the radial deflection of the armature shaft is reduced by local deformation of the shaft portion on the side of the bearing element remote from the laminated portion.

Abstract: The invention generally relates to immunotherapy with chimeric antigen receptor (CAR}- engineered T-cells. In particular, the invention relates immunotherapy with chimeric antigen receptor (CAR)-engineered T-cells to target sub-populations of cancer cells that are characterized by low expression of a cancer cell surface antigen, more particular the invention relates to immunotherapy with chimeric antigen receptor (CAR)-engineered T-cells targeting CD19 (CD19CART) in multiple myeloma, a clonal proliferation of plasma cells.

Abstract: The method provides detection of a plurality of spatial parameters which are assigned to one or both forearms of an operator. Processing markers generated from the spatial parameters are visualized in a virtual scene. The operator activates processing markers and carries out processing operations by changing the position of his or her forearm(s). After the processing operations are complete, the operator deactivates the assignment between processing marker and manipulation marker by rotating a forearm. A particular advantage of the method disclosed herein compared with conventional methods lies in the activation and deactivation using the rotation of a forearm of the operator. A rotation of the wrist may be carried about largely independently of the direction in which the forearm is pointing.

Abstract: Method and microscope for determining a fluorescence intensity which is integrated over a partial region of an isolated intensity distribution, from a first individual image is corrected by means of a background intensity value, integrated over the same image region, from another individual image in which this image region is free from fluorescence. The axial position can be ascertained on the basis of two thus corrected fluorescence intensity values from, in each case, different partial regions of the intensity distribution.

Abstract: The method provides detection of a plurality of spatial parameters which are assigned to one or both forearms of an operator. Processing markers generated from the spatial parameters are visualized in a virtual scene. The operator activates processing markers and carries out processing operations by changing the position of his or her forearm(s). After the processing operations are complete, the operator deactivates the assignment between processing marker and manipulation marker by rotating a forearm. A particular advantage of the method disclosed herein compared with conventional methods lies in the activation and deactivation using the rotation of a forearm of the operator. A rotation of the wrist may be carried about largely independently of the direction in which the forearm is pointing.

Abstract: A gemstone with a chaton cut has tapering facets of a crown adjoin a flat table all the way round inclined relative to the table. The facets extend as far as a rondist at which the gemstone has the largest transverse dimension. A pavilion of facets, preferably terminating at a point, adjoins below the rondist. The gemstone is at least partially made of glass, and the crown angle (?) is between 40.5° and 42.5°.

Abstract: A method for aligning an armature shaft, wherein in a first step a concentricity error of the armature shaft is determined in the region of the shaft portion by measuring a radial deflection of the armature shaft, and wherein in a second step the radial deflection of the armature shaft is reduced by local deformation of the shaft portion on the side of the bearing element remote from the laminated portion.

Abstract: Brilliant-cut gemstone, wherein the crown angle (?) is between 32.8° and 33.0°.

Abstract: The invention relates to a method for the production of a flexible, gas-tight, and transparent composite film, comprising a transparent carrier layer made of plastic and a glass-like layer. The method comprises the following steps: a) a temperature-resistant substrate is coated with a lacquer comprising glass or glass-forming pre-stages by a wet chemical process, b) the coating is thermally compressed to form the glass-like layer, c) the transparent carrier layer made of plastic is applied onto the glass-like layer and bonded thereto, and d) the composite of the carrier layer and the glass-like layer is separated from the substrate. The composite films obtained in this way are suitable as encapsulation material or packing material, particularly for the use in displays, illumination and photovoltaics, for example for light-emitting diodes, solar cells, displays, or electronic circuits.

Abstract: The present invention relates to a process for improving the photostability and/or control of the fluorescence intensity of a fluorescent dye wherein a fluorescent dye is admixed with a redox buffer comprising at least one reducing agent and/or at least one oxidizing agent and/or at least one reducing-oxidizing agent, and also to a fluorescent dye composition comprising a fluorescent dye and a redox buffer comprising at least one reducing agent and at least one oxidizing agent or at least one reducing-oxidizing agent.

Abstract: The invention relates to an oligonucleotide which serves as a nucleic acid probe comprising a loop section with a loop sequence complementary to the target sequence of the nucleic acid molecule; a stem section arranged on both ends of the loop section for hybridizing with each other for closing the oligonucleotides thereby forming a loop, and wherein one of the stem sections is labeled with fluorescent color, such that when the loop section hybridizes with the target sequence of the nucleic acid, the oligonucleotide opens and the distance between the fluorophore and a quencher nuleoside increases which thereby prevents quenching of the fluorescence and the strength of fluorescence when measured indicates the presence of the nucleic acid with the target sequence.

Abstract: The invention relates to a device and a method for the detection, especially on line detection, of an amplification of a DNA and/or RNA sequence in a sample. The amplification of the DNA and/or RNA sequence in the sample is evaluated on the basis of scattered-light signal of the sample.

Abstract: The invention relates to an oligonucleotide which serves as a nucleic acid probe comprising a loop section with a loop sequence complementary to the target sequence of the nucleic acid molecule; a stem section arranged on both ends of the loop section for hybridizing with each other for closing the oligonucleotides thereby forming a loop, and wherein one of the stem sections is labeled with fluorescent color, such that when the loop section hybridizes with the target sequence of the nucleic acid, the oligonucleotide opens and the distance between the fluorophore and a quencher nuleoside increases which thereby prevents quenching of the fluorescence and the strength of fluorescence when measured indicates the presence of the nucleic acid with the target sequence.

Abstract: System and method for distinguishing at least two types of molecule groups that are bound to analyte molecules and which have different fluorescent characteristics. The system performs differentiation using time-resolved fluorescence measurement and includes a light source that exposes a first sample volume to light that is suitable for exciting the at least two types of molecule groups to fluorescence. The system also includes a detector for detecting fluorescence radiation emitted from a second sample volume that at least partially overlaps the first sample volume, and a control unit that is designed to activate the light source for a time interval T.sub.1 and, after time interval T.sub.2 has passed, to activate the detector for a time interval T.sub.3. According to this system, the illumination and detection of emitted fluorescence radiation is performed at least 1,000 times per millisecond, the detector signals recorded with a recording unit during time interval T.sub.