Abstract: Device for the controlled release of a predefined quantity of a substance and method for the production of a device for the controlled release of a predefined quantity of a substance. To realize a controlled delivery of a substance based upon a multiplicity of individual compartments, the reservoirs are formed in plastic substrates that allow the substance delivery device to be flexible and conformal with both internal and external body parts. The fabrication technology for the plastic drug release reservoirs is compatible with active matrix array technology, allowing control of delivery to be based upon active matrix principles. Applications are for controlled external drug delivery (patches), implantable drug delivery and oral drug delivery (electronic pill).