Patents by Inventor Marleen Eveline WEERDENBURG

Marleen Eveline WEERDENBURG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FIMH MUTANTS, COMPOSITIONS THEREWITH AND USE THEREOF
    Publication number: 20230406890
    Abstract: Polypeptides comprising a FimH lectin domain comprising at least one an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.
    Type: Application
    Filed: June 26, 2023
    Publication date: December 21, 2023
    Inventors: Jan GRIJPSTRA, Marleen Eveline WEERDENBURG, Jeroen GEURTSEN, Cristhina Kellen FAE, Jakob Louris FEITSMA
  • FimH mutants, compositions therewith and use thereof
    Patent number: 11725028
    Abstract: Polypeptides comprising a FimH lectin domain comprising at least one an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.
    Type: Grant
    Filed: January 11, 2022
    Date of Patent: August 15, 2023
    Assignee: JANSSEN PHARMACEUTICALS, INC.
    Inventors: Jan Grijpstra, Marleen Eveline Weerdenburg, Jeroen Geurtsen, Cristhina Kellen Fae, Jakob Louris Feitsma
  • FimH mutant, compositions therewith and use thereof
    Publication number: 20230049056
    Abstract: Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.
    Type: Application
    Filed: July 26, 2022
    Publication date: February 16, 2023
    Inventors: Jan GRIJPSTRA, Marleen Eveline WEERDENBURG, Jeroen GEURTSEN, Christhina Kellen FAE, Jakob Louris FEITSMA
  • Production of E. coli O18 Bioconjugates
    Publication number: 20220323576
    Abstract: The invention pertains to host cells for producing a bioconjugate of an E. coli O18 antigen polysaccharide conjugated to a carrier protein. The host cells are characterized in that they comprise modified Wzy O-antigen polymerases with specific combinations of amino acid substitutions in one or more of positions 199, 377 and 395 as compared to the wild type Wzy O-antigen polymerase of SEQ ID NO: 1, which modified Wzy O-antigen polymerases improve the yield and glycosylation pattern of the O18 bioconjugates produced by the host cells. The invention further relates to methods wherein the host cells are used to produce a bioconjugate of an E. coli O18 antigen polysaccharide conjugated to a carrier protein, compositions comprising these bioconjugates, including multivalent compositions comprising bioconjugates of additional O antigen polysaccharide-serotypes.
    Type: Application
    Filed: March 31, 2022
    Publication date: October 13, 2022
    Inventors: Jeroen GEURTSEN, Marleen Eveline WEERDENBURG, Pieter Jan BURGHOUT
  • FimH mutant, compositions therewith and use thereof
    Patent number: 11421003
    Abstract: Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: August 23, 2022
    Assignee: Janssen Pharmaceuticals, Inc.
    Inventors: Jan Grijpstra, Marleen Eveline Weerdenburg, Jeroen Geurtsen, Cristhina Kellen Fae, Jakob Louris Feitsma
  • FimH mutant, compositions therewith and use thereof
    Publication number: 20210221856
    Abstract: Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.
    Type: Application
    Filed: January 15, 2021
    Publication date: July 22, 2021
    Inventors: Jan GRIJPSTRA, Marleen Eveline WEERDENBURG, Jeroen GEURTSEN, Cristhina Kellen FAE, Jakob Louris FEITSMA