Patents by Inventor Marlise I. Klein

Marlise I. Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanoparticles for controlled release of anti-biofilm agents and methods of use
    Patent number: 9566247
    Abstract: The present invention relates to compositions and methods to treat and/or prevent biofilms and biofilm related diseases. The invention comprises a nanoparticle carrier (NPC) and at least one therapeutic agent therein. The NPC binds within biofilm and to surfaces at risk for biofilm formation and accumulation while providing local, sustained, enhanced and controlled delivery of the therapeutic agent, when triggered for release. In one embodiment, the NPC comprises pH-responsive elements that allows for specific delivery of the therapeutic agent when the local environment dictates that the agent should be delivered precisely when it is most needed.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: February 14, 2017
    Assignee: University of Rochester
    Inventors: Hyun Koo, Danielle Benoit, Marlise I. Klein, Megan L. Falsetta Wood
  • Nanoparticles for Controlled Release of Anti-Biofilm Agents and Methods of Use
    Publication number: 20150374634
    Abstract: The present invention relates to compositions and methods to treat and/or prevent biofilms and biofilm related diseases. The invention comprises a nanoparticle carrier (NPC) and at least one therapeutic agent therein. The NPC binds within biofilm and to surfaces at risk for biofilm formation and accumulation while providing local, sustained, enhanced and controlled delivery of the therapeutic agent, when triggered for release. In one embodiment, the NPC comprises pH-responsive elements that allows for specific delivery of the therapeutic agent when the local environment dictates that the agent should be delivered precisely when it is most needed.
    Type: Application
    Filed: February 25, 2014
    Publication date: December 31, 2015
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Hyun Koo, Danielle Benoit, Marlise I. Klein, Megan L. Falsetta Wood